PET Imaging of Dopamine D2 Receptors with [18F]Fluoroclebopride in Monkeys Effects of Isoflurane- and Ketamine-Induced Anesthesia

Nader, Michael A.; Grant, Kathleen A.; Gage, H. Donald; Ehrenkaufer, Richard L.; Kaplan, Jay R.; Mach, Robert H.

doi:10.1016/s0893-133x(98)00101-8

Cited by 27 publications

(21 citation statements)

References 35 publications

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“…As in humans, the menstrual cycle in female macaques was observed to last approximately 28 days; the appropriate phase was confirmed in this study by measuring plasma progesterone levels on the days PET scans were conducted. Measures of D2 receptor availability were approximately 12% higher in the luteal phase compared to the follicular phase in the caudate nucleus and putamen, a degree of variation that is well outside the reported between-studies variability of FCP (approximately 2%; Nader et al, 1999). These findings suggest that menstrual cycle can influence striatal DA receptor availability, which may be a neurobiological mechanism underlying menstrual cycle-related changes in symptoms and clinical efficacy for treatments of neurodegenerative and affective disorders (eg Tolson et al, 2002;Terner and de Wit, 2006).…”

Section: Discussionmentioning

confidence: 63%

“…This dose of ketamine does not affect D2 receptor availability as measured with FCP (Nader et al, 1999). Details regarding the PET data acquisition protocol, blood sampling procedure, and metabolite analysis have been fully described previously (Mach et al, 1996(Mach et al, , 1997Morgan et al, 2002;Nader et al, 1999). An arterial and a venous catheter were inserted by percutaneous stick for blood sampling and tracer injection, respectively.…”

Section: Mr and Pet Imagingmentioning

confidence: 99%

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Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Czoty

Riddick

Gage

et al. 2008

Neuropsychopharmacol

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Sex differences have been reported in a variety of affective and neurodegenerative disorders that involve dysfunctional dopamine (DA) neurotransmission. In addition, there is evidence for differences in sensitivity to the abuse-related effects of psychostimulants across the menstrual cycle which may result from effects of ovarian hormones on DA function. The goal of the present study was to extend previous work examining menstrual cycle-related changes in DA D2 receptor availability in humans to drug-naive female cynomolgus monkeys (n ¼ 7) using the selective D2-like receptor ligand [ 18 F]fluoroclebopride (FCP) and a high-resolution microPET P4 scanner. Menstrual cycle phase was characterized by daily vaginal swabs and measurements of serum progesterone levels. PET studies were conducted once during the luteal phase and once during the follicular phase. Regions of interest in the caudate nucleus, putamen, and cerebellum were defined on coregistered MRIs. Distribution volumes were calculated for FCP in each structure and the distribution volume ratio (DVR) for both brain regions relative to the cerebellum was used as a measure of D2 receptor availability. FCP DVRs were significantly higher in the luteal phase compared to the follicular phase in both the caudate nucleus (11.7% difference, p ¼ 0.02) and putamen (11.6% difference, p ¼ 0.03). These findings extend earlier work in humans and suggest that changes in DA receptor availability may be involved in the variation in symptoms of various neuropsychiatric disorders across the menstrual cycle, including differences in sensitivity to the abuse-related effects of stimulants.

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Section: Discussionmentioning

confidence: 63%

Section: Mr and Pet Imagingmentioning

confidence: 99%

Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Czoty

Riddick

Gage

et al. 2008

Neuropsychopharmacol

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“…This induction protocol has no effect on [ 18 F]FCP DVRs (Nader et al 1999a). Catheters (22-gauge angiocath; Becton Dickinson Vascular Access, Sandy, Utah, USA) were placed in an external artery and vein by percutaneous sticks and lactated ringer's solution (IV) was delivered to the monkey throughout the study.…”

Section: Drugsmentioning

confidence: 99%

“…Methodological details regarding the data acquisition protocol, blood sampling and metabolite analysis for [ 18 F]fluoroclebopride (FCP) have been described previously (Mach et al 1996;Nader et al 1999a). Image acquisition occurred on a GE Advance NXi PET Scanner (General Electric Systems, Milwaukee, Wisc.).…”

Section: Drugsmentioning

confidence: 99%

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

et al. 2004

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These results suggest that D(1) receptor function is not substantially influenced by social rank in monkeys from well-established social groups. While an earlier study showed that dominant monkeys had higher D(2) receptor levels and were less sensitive to the reinforcing effects of cocaine during initial exposure, the present findings indicate that long-term cocaine use changed D(2) receptor levels such that D(2) receptor function and cocaine reinforcement were not different between social ranks. These findings suggest that cocaine exposure attenuated the impact of social housing on DA receptor function.

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“…Such an experiment implies two major constraints: the use of a rotating collector set on the top of the rodent cage on which a photodetection module will be plugged (this component, currently used for in vivo electrophysiological experiments, will enable the rat to move almost unrestrained while the experiment is performed) and chronic arterial catheters on rats, which will allow one to inject the radiotracer and take blood samples. In addition, to minimize tissue damage caused by probe implantation, we have examined the effects of chronic implantation of 500-m diameter probes, which permit longitudinal studies of neurodegenerative or plastic processes in freely behaving rodents, thus avoiding the well described effects of anesthesia on local blood flow, energetic metabolism (23)(24)(25), or radiotracer binding (26)(27)(28).…”

Section: Anaesthetized Ratsmentioning

confidence: 99%

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β ⁺ -sensitive microprobe

Pain¹,

Besret²,

Vaufrey³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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Understanding brain disorders, the neural processes implicated in cognitive functions and their alterations in neurodegenerative pathologies, or testing new therapies for these diseases would benefit greatly from combined use of an increasing number of rodent models and neuroimaging methods specifically adapted to the rodent brain. Besides magnetic resonance (MR) imaging and functional MR, positron-emission tomography (PET) remains a unique methodology to study in vivo brain processes. However, current high spatialresolution tomographs suffer from several technical limitations such as high cost, low sensitivity, and the need of restraining the animal during image acquisition. We have developed a ␤ ؉ -sensitive high temporal-resolution system that overcomes these problems and allows the in vivo quantification of cerebral biochemical processes in rodents. This ␤-MICROPROBE is an in situ technique involving the insertion of a fine probe into brain tissue in a way very similar to that used for microdialysis and cell electrode recordings. In this respect, it provides information on molecular interactions and pathways, which is complementary to that produced by these technologies as well as other modalities such as MR or fluorescence imaging. This study describes two experiments that provide a proof of concept to substantiate the potential of this technique and demonstrate the feasibility of quantifying brain activation or metabolic depression in individual living rats with 2-[ 18 F]fluoro-2-deoxy-D-glucose and standard compartmental modeling techniques. Furthermore, it was possible to identify correctly the origin of variations in glucose consumption at the hexokinase level, which demonstrate the strength of the method and its adequacy for in vivo quantitative metabolic studies in small animals.A lterations in local cerebral metabolic rate of glucose (lCMRglc) have been reported in several human brain conditions such as psychiatric disorders or neurodegenerative diseases. Understanding the cellular mechanisms involved in these diseases and the development of new therapeutic strategies will advance more rapidly through the use of animal models. The quantitation of metabolic rates in the rodent brain was achieved initially by using the 2-deoxy-D-[ 14 C]glucose autoradiographic method (1). Although efficient, this technique requires the sacrifice of several animals to obtain each time point and thus can provide only ex vivo, averaged kinetic constants calculated from values obtained from various animals. As an alternative, positron-emission tomography (PET), an imaging technology designed to use compounds labeled with positron-emitting radioisotopes to image and measure biochemical processes in vivo, has been adapted to use in small animals. The implementation of several high spatial-resolution PET scanners within the last several years (2-9) has enabled the adaptation of the 2-deoxy-D-[ 14 C]glucose method to in vivo imaging of small animals by using 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG) as a tracer. However, such PE...

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PET Imaging of Dopamine D2 Receptors with [18F]Fluoroclebopride in Monkeys Effects of Isoflurane- and Ketamine-Induced Anesthesia

Abstract: The purpose of the present study was to determine whether positron emission tomography (PET)

Cited by 27 publications

References 35 publications

Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β ⁺ -sensitive microprobe

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PET Imaging of Dopamine D2 Receptors with [18F]Fluoroclebopride in Monkeys Effects of Isoflurane- and Ketamine-Induced Anesthesia

Abstract: The purpose of the present study was to determine whether positron emission tomography (PET)

Cited by 27 publications

References 35 publications

Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Effect of Menstrual Cycle Phase on Dopamine D2 Receptor Availability in Female Cynomolgus Monkeys

Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β + -sensitive microprobe

Contact Info

Product

Resources

About

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β ⁺ -sensitive microprobe