PET imaging of glucose and fatty acid metabolism for NAFLD patients

Gullberg, Grant T.; Shrestha, Uttam; Seo, Youngho

doi:10.1007/s12350-018-01532-8

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…Thus, there is a real need for the further development of metabolically stable fatty acid tracers that can compete with the clinical use of [ 18 F]FDG for glucose uptake. The further development of PET probes for fatty acid uptake in NAFLD have been recently reviewed [44].…”

Section: Discussionmentioning

confidence: 99%

Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

Peng

et al. 2022

Pharmaceuticals

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The world-wide high incidence of non-alcoholic fatty liver disease (NAFLD) is of concern for its progression to insulin resistance, steatohepatitis and cardiovascular disease (CVD). The increased uptake of fatty acids in critical organs plays a major role in NAFLD progression. Male Ceacam1−/− mice that develop NAFLD, insulin resistance and CVD on normal chow are a potential model for studying the dysregulation of fatty acid uptake. [18F]fluoro-4-thia-oleate ([18F]FTO) was chosen as a fatty acid reporter because of its higher uptake and retention in the heart in an animal model of CVD. Male wild-type (WT) or Ceacam1−/− mice fasted 4–6 h were administered [18F]FTO i.v., and dynamic PET scans were conducted in an MR/PET small animal imaging system along with terminal tissue biodistributions. Quantitative heart image analysis revealed significantly higher uptake at 35 min in Ceacam1−/− (6.0 ± 1.0% ID/cc) vs. WT (3.9 ± 0.6% ID/cc) mice (p = 0.006). Ex vivo heart uptake/retention (% ID/organ) was 2.82 ± 0.45 for Ceacam1−/− mice vs. 1.66 ± 0.45 for WT mice (p < 0.01). Higher kidney and pancreas uptake/retention in Ceacam1−/− was also evident, and the excretion of [18F]FTO into the duodenum was observed for both WT and Ceacam1−/− mice starting at 10 min. This study suggests that the administration of [18F]FTO as a marker of fatty acid uptake and retention may be an important tool in analyzing the effect of NAFLD on lipid dysregulation in the heart.

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Section: Discussionmentioning

confidence: 99%

Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

Peng

et al. 2022

Pharmaceuticals

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“…CXC-motif chemokine receptor 4 (CXCR-4) is also overexpressed on many immune cells, particularly monocytes and mac- 18 F-FDG PET imaging is non-specific; therefore, it is complicated by highly metabolic neighboring tissues such as myocardial cells and neurons [38,47,48]. The suppression of myocardial 18 F-FDG uptake can be achieved through dietary manipulation (high-fat, low-carb) to shift the body into beta-oxidation of fatty acids instead of metabolizing glucose as a primary energy source to try and limit this background activity [49,50]. Other radiotracers can be utilized that are specific to macrophages, limiting the effects from other highly metabolic cells.…”

Section: Imaging Inflammatory Disease 21 Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Molecular Imaging of Inflammatory Disease

et al. 2021

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Inflammatory diseases include a wide variety of highly prevalent conditions with high mortality rates in severe cases ranging from cardiovascular disease, to rheumatoid arthritis, to chronic obstructive pulmonary disease, to graft vs. host disease, to a number of gastrointestinal disorders. Many diseases that are not considered inflammatory per se are associated with varying levels of inflammation. Imaging of the immune system and inflammatory response is of interest as it can give insight into disease progression and severity. Clinical imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI) are traditionally limited to the visualization of anatomical information; then, the presence or absence of an inflammatory state must be inferred from the structural abnormalities. Improvement in available contrast agents has made it possible to obtain functional information as well as anatomical. In vivo imaging of inflammation ultimately facilitates an improved accuracy of diagnostics and monitoring of patients to allow for better patient care. Highly specific molecular imaging of inflammatory biomarkers allows for earlier diagnosis to prevent irreversible damage. Advancements in imaging instruments, targeted tracers, and contrast agents represent a rapidly growing area of preclinical research with the hopes of quick translation to the clinic.

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“…“The reasons for alterations of the biochemical processes of myocardial glucose uptake in patients with NAFLD is not clear, but probably is the result of several complex biochemical processes involving genetic factors, atherosclerosis, inflammatory cytokines, insulin resistance, and other alterations in biochemistry of glucose and fatty acid metabolism,” as pointed out by Gullberg et al in an accompanying editorial. 70 …”

Section: Extra Cardiac Imagingmentioning

confidence: 99%

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance

AlJaroudi

Hage

2021

Journal of Nuclear Cardiology

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Although the year 2020 was different from other years in many respects, the Journal of Nuclear Cardiology published excellent articles pertaining to imaging in patients with cardiovascular disease due to the dedication of the investigators in our field all over the world. In this review, we will summarize a selection of these articles to provide a concise review of the main advancements that have recently occurred in the field and provide the reader with an opportunity to review a wide selection of articles. We will focus on publications dealing with positron emission tomography, computed tomography, and magnetic resonance and hope that you will find this review helpful.

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PET imaging of glucose and fatty acid metabolism for NAFLD patients

Cited by 6 publications

References 41 publications

Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

Molecular Imaging of Inflammatory Disease

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance

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