PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis

Tamura, Yasuhisa; Kataoka, Yosky

doi:10.1080/23262133.2017.1281861

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…Another possibility is that GH has induced the outbreak of dendritic spines and changes in the length and density of pre-existing dendrites in the hippocampus, as has been shown to occur after intracerebroventricular administration of the hormone in adult rats [ 42 ]. If we could have used 3′-deoxy-3′-[18F] fluoro- l -thymidine instead of FDG, we could have detected whether the changes observed in PET-SCAN were due or not to adult neurogenesis, as a study has shown in adult rats [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

Devesa¹,

Núñez²,

Agra³

et al. 2018

IJMS

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(1) Background: We analyzed, using PET-SCAN and cognitive tests, how growth hormone (GH) could act in the brain of an older woman, not deficient in GH, who showed mild cognitive alterations (MCI) and had a genotype of ApoE 4/3 and familial dyslipidemia. (2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to knowledge, memory, and behavior was analyzed using 18-F fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day, subcutaneous) for three weeks and on the last day under this treatment, a new PET-SCAN was performed. One month after beginning treatment with GH, a new TAVEC test was performed. (3) Results: GH administration normalized the cognitive deficits observed in the first psychometric test and significantly (p < 0.025) increased the metabolic activity in practically all brain cortical areas, specifically in the left hippocampus and left amygdala, although not in the left parahippocampus. (4) Conclusions: This study demonstrates for the first time the positive effects of GH on cerebral metabolism in a patient without GH deficiency, recovering the function of affected areas related to knowledge, memory, and behavior in an elderly patient with MCI.

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Section: Discussionmentioning

confidence: 99%

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

Devesa¹,

Núñez²,

Agra³

et al. 2018

IJMS

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“…Further clinical studies are profoundly needed to confirm reproducibility of previous findings in humans and to dissect the neurobiological basis of physical exercise benefits. We argue that imaging studies (positron emission tomography (PET) and magnetic resonance imaging (MRI) will be instrumental to characterize the impact of PE on oxidative stress (this is a classical METH neurotoxicity hallmark), BBB integrity, and neurogenesis (two recent and exciting hallmarks) in METH addicts . Preclinical studies and clinical trials should use physical exercise conjointly with some promising drugs such as mirtazapine, bupropion, and methylphenidate.…”

Section: Discussionmentioning

confidence: 99%

The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine." Relevant references from key publications and gray literature were also reviewed to identify additional citations for inclusion. Original investigation regarding physical exercise and methamphetamine addiction (clinical data) or neurobiological mechanisms of physical exercise in animal models of methamphetamine administration (preclinical data) was included. Overall, METH users demonstrated improvements, including better fitness and emotional measures, lower relapse rates, and sustained abstinence when compared to nonexercised individuals. The neurobiological mechanisms of physical exercise in METH users seem to reflect an interplay of several agents, including neurochemicals, oxidative stress, neurogenesis, gliogenesis, and blood-brain barrier as disclosed by preclinical data. Exercise-based interventions alone or as a conjoint therapy may be a useful tool for managing METH addiction.

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“…Data from this study may contribute to clarify these controverses. If we could have used 3'-deoxy-3'-[18F]fluoro-L-thymidine instead of FDG we could have detected if the changes observed in the PET-SCAN were or were not due to the neurogenesis of the adult, as a study analyzed in adult rats [28].…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone (GH) Administration Increases the Metabolic Activity of the left Hippocampus in an Elder Patient with Cognitive Disorders

Devesa¹,

Núñez²,

Agra³

et al. 2018

Preprint

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1) Background: We analyzed, by PET-SCAN, how growth hormone (GH) might act on the brain of a not GH-deficient elder woman who suspected that she was developing Alzheimer's disease; 2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to cognition, memory and behavior was analyzed by 18-F Fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day) during three weeks and the last day under this treatment a new PET-SCAN was carried out. One month after commencing the treatment with GH a new TAVEC test was performed; 3) Results: GH administration normalized the cognitive deficits observed in the first cognitive test and significantly (p < 0.025) increased (Voxel-Based Morphometry) the metabolic activity in the left hippocampus, left amygdala and left parahippocampus, but also in practically all brain cortical areas; 4) Conclusions: This is the first study in which the effects of GH on the brain have been visualized in images. Our data confirm the positive effects of this hormone on cognition and memories; although they do not allow us to conclude whether GH administration may be useful in the early stages of Alzheimer's disease, they seem to be promising.

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PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis

Cited by 11 publications

References 36 publications

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

The neurobiological mechanisms of physical exercise in methamphetamine addiction

Growth Hormone (GH) Administration Increases the Metabolic Activity of the left Hippocampus in an Elder Patient with Cognitive Disorders

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