PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison

Queiroz, Marcelo A.; Ra, Kubik-Huch; Hauser, Nik; Freiwald-Chilla, Bianka; Schulthess, G; Froehlich, Johannes M.; Veit-Haibach, Patrick

doi:10.1007/s00330-015-3657-8

Cited by 112 publications

(66 citation statements)

References 34 publications

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“…Functional techniques (DWI, MRI enhanced with lymph-node specific contrast agents, and PET/MRI) may improve the detection of nodal metastases independent of size (78–81). Lymph nodes appear as discreet high SI ovoid structures on high b-value DWI increasing their conspicuity and facilitating detection.…”

Section: Part Iv: Fertility-sparing Management Of Cervical Cancermentioning

confidence: 99%

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Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

et al. 2017

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Historically, cancer treatment has emphasized measures for the “cure” regardless of the long-term consequences. Advances in cancer detection and treatment have resulted in improved outcomes bringing to the fore various quality of life considerations including future fertility. For many young cancer patients, fertility preservation is now an integral component of clinical decision-making and treatment design. Optimal fertility-sparing options for young patients with gynecologic cancer are influenced by patient age, primary cancer, treatment regimens, and patient preferences. Possible approaches include embryo or oocyte cryopreservation, ovarian transposition, conservative surgery, and conservative medical treatment to delay radical surgery. These may be used alone or in combination to maximize fertility preservation. Awareness of the various fertility-sparing options, eligibility criteria, and the central role of Magnetic Resonance Imaging (MRI) in the proper selection of patients will enable radiologists to produce complete clinically relevant imaging reports and serve as effective consultants to referring clinicians. Knowledge of the potential imaging pitfalls is essential to avoid misinterpretation and guide appropriate management.

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Section: Part Iv: Fertility-sparing Management Of Cervical Cancermentioning

confidence: 99%

“…This approach has the potential to provide a “one-stop-shop” evaluation of the primary tumor and lymph nodes (80, 81). …”

Section: Part Iv: Fertility-sparing Management Of Cervical Cancermentioning

confidence: 99%

Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

et al. 2017

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“…High soft tissue contrast information from MRI provides greater improvement of primary tumor delineation by PET/MRI than PET/CT in terms of tissue invasion, relation to surrounding structures, and characterization [50]. In patients with suspected recurrence of cervical or ovarian cancer, detection rate of malignant lesion was higher in simultaneous PET/MR imaging than MRI alone (98.9 % vs. 88.8 %) and diagnostic confidence increased in PET/MRI more than MRI or PET/CT [51,52].…”

Section: Gynecologic Cancer and Pelvic Malignancymentioning

confidence: 99%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

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The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

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“…Zusätzlich konnte durch die Einfüh-rung der 18 F-Fluordesoxyglukose-Positronenemissionstomographie ( 18 F-FDG-PET) sowie der erfolgreichen Implementierung hybrider Bildgebungstechniken wie der PET-CT eine Verbesserung der diagnostischen Genauigkeit beim Nachweis einer Metastasierung oder von Rezidiven gynäkologischer Tumore erreicht werden [2][3][4][5]. Seit Kurzem sind die weltweit ersten kombinierten PET-MRT-Geräte im klinischen Gebrauch.…”

Section: Lokal-und Ganzkörperdiagnostik Weiblicher Beckentumoreunclassified

“…Die PET-CT besitzt als hybride Bildgebungstechnik die höchste Sensitivität unter den bildgebenden Modalitä-ten, deren Einsatz selbst bei negativem oder unklarem Befund in der konventionellen Diagnostik und weiterhin bestehendem Verdacht in Erwägung gezogen werden sollte [4,26]. Einzelne initiale Studien an Mischkollektiven von Neoplasien des weiblichen Beckens (inklusive dem Ovarialkarzinom) berichten über eine vergleichbare diagnostische Aussagekraft der PET-MRT mit der PET-CT in der Rezidivdiagnostik [10,18]. Darüber hinaus wird die Überlegenheit der hybriden Bildgebung gegenüber der konventionellen Diagnostik durch eine initiale Vergleichsstudie zwischen hybrider PET-MRT und MRT für das Restaging gynä-kologischer Beckentumore gestützt [27].…”

Section: Ovarialkarzinomunclassified

Lokal- und Ganzkörperdiagnostik weiblicher Beckentumore

Grueneisen

Umutlu

2016

Radiologe

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Integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) scanning has recently become established in clinical imaging. Various studies have demonstrated the great potential of this new hybrid imaging procedure for applications in the field of oncology and the diagnostics of inflammatory processes. With initial studies demonstrating the feasibility and high diagnostic potential of PET/MRI comparable to PET-computed tomography (CT), the focus of future studies should be on the identification of application fields with a potential diagnostic benefit of PET/MRI over other established diagnostic tools. Both MRI and PET/CT are widely used in the diagnostic algorithms for malignancies of the female pelvis. A simultaneous acquisition of PET and MRI data within a single examination provides complementary information which can be used for a more comprehensive evaluation of the primary tumor as well as for whole body staging. Therefore, the aim of this article is to outline potential clinical applications of integrated PET/MRI for the diagnostic work-up of primary or recurrent gynecological neoplasms of the female pelvis.

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PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison

Cited by 112 publications

References 34 publications

Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Lokal- und Ganzkörperdiagnostik weiblicher Beckentumore

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