PET/MRI: Current state of the art and future potential for cardiovascular applications

Adenaw, Nebiyu; Salerno, Michael

doi:10.1007/s12350-013-9780-5

Cited by 26 publications

(14 citation statements)

References 66 publications

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“…Hybrid PET/MRI is emerging as a novel diagnostic modality for cardiac imaging with the promise of playing an exciting role in multiple cardiovascular applications [2,23]. Contrary to PET/CT, however, hybrid PET/MRI does not directly provide the data needed for AC as the signal intensity in the MR image is not directly related to photon attenuation.…”

Section: Discussionmentioning

confidence: 99%

MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction

Vontobel

Liga

Possner

et al. 2015

Eur J Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 99%

MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction

Vontobel

Liga

Possner

et al. 2015

Eur J Nucl Med Mol Imaging

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“…The recently available hybrid modality PET/MR imaging allows combination of both metabolic and anatomic information about the cancer (8)(9)(10). PET/MR imaging is a rapidly evolving modality whose full potential has yet to be discovered and whose diagnostic utility in esophageal cancer has yet to be addressed in the literature.…”

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confidence: 99%

Clinical Implication of PET/MR Imaging in Preoperative Esophageal Cancer Staging: Comparison with PET/CT, Endoscopic Ultrasonography, and CT

et al. 2014

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This was a study to compare the diagnostic efficacies of endoscopic ultrasonography (EUS), CT, PET/MR imaging, and PET/CT for the preoperative local and regional staging of esophageal cancer, with postoperative pathologic stage used as the reference standard. Methods: During 1 y, 19 patients with resectable esophageal cancer were enrolled and underwent preoperative EUS, CT, PET/CT, and PET/MR imaging. A chest radiologist and nuclear medicine physician retrospectively reviewed the images and assigned tumor and lymph node stages according to the seventh version of the TNM system and the American Joint Committee on Cancer staging system. Four patients who were treated nonsurgically were excluded from data analysis. The efficacies of EUS, CT, PET/CT, and PET/MR imaging were compared. Results: Primary tumors were correctly staged in 13 (86.7%), 10 (66.7%), and 5 (33.3%) patients at EUS, PET/MR imaging, and CT, respectively (P value ranging from 0.021 to 0.375). The accuracy of determining T1 lesions was 86.7%, 80.0%, and 46.7% for EUS, PET/MR imaging, and CT, respectively. For distinguishing T3 lesions, the accuracy was 93.3% for EUS and 86.7% for both PET/MR imaging and CT. For lymph node staging, the accuracy was 83.3%, 75.0%, 66.7%, and 50.0% for PET/MR imaging, EUS, PET/CT, and CT, respectively. In addition, area-under-the-curve values were 0.800, 0.700, 0.629, and 0.543 for PET/MR imaging, EUS, PET/CT, and CT, respectively. Conclusion: PET/MR imaging demonstrated acceptable accuracy for T staging compared with EUS and, although not statistically significant, even higher accuracy than EUS and PET/CT for prediction of N staging. With adjustments in protocols, PET/MR imaging may provide an important role in preoperative esophageal cancer staging in the future. Accur ate staging of esophageal cancer is critical for decisions on patient treatment. Current practice guidelines for the staging of esophageal cancer include CT of the chest and abdomen, endoscopic ultrasonography (EUS), and PET/CT (1). EUS is a relatively accurate modality for evaluating primary tumor depth compared with CT, which cannot identify the histologic layers of the esophageal wall; thus, the role of CT is usually limited to exclusion of T4 cancers (2,3).Considering nodal metastasis, CT scans, which depend on size criteria, have relatively poor diagnostic performance, as enlarged lymph nodes may be reactive and normal-sized lymph nodes may be positive for metastasis (4,5). Currently, a combination of EUS with or without fine-needle aspiration and PET/CT is widely accepted for assessment of nodal metastasis (1). However, certain lymph nodes that are not immediately adjacent to the esophagus could be dismissed, and the EUS probes, which are typically larger than standard endoscopic probes, are not feasible if the lumen has been narrowed by a large tumor or stricture. PET/CT supports the role of EUS and CT because the maximum standardized uptake value helps identify patients with T1 cancers and pathologic lymph nodes, but the diagnostic accuracy stil...

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“…Such fusion of different imaging modalities can supply complementary data in a single examination [86] and allows leveraging the strengths of each modality, improves the diagnosis, management and prediction of clinical outcomes of various cardiovascular diseases and, firstly, CAD.…”

Section: Integration or Fusion Of Different Imaging Modalitiesmentioning

confidence: 99%

Positron Emission Tomography in the Diagnosis and Management of Coronary Artery Disease

Kazakauskaitė

Žaliaduonytė-Pekšienė

Rumbinaitė

et al. 2018

Medicina

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Cardiac positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are encouraging precise non-invasive imaging modalities that allow imaging of the cellular function of the heart, while other non-invasive cardiovascular imaging modalities are considered to be techniques for imaging the anatomy, morphology, structure, function and tissue characteristics. The role of cardiac PET has been growing rapidly and providing high diagnostic accuracy of coronary artery disease (CAD). Clinical cardiology has established PET as a criterion for the assessment of myocardial viability and is recommended for the proper management of reduced left ventricle (LV) function and ischemic cardiomyopathy. Hybrid PET/CT imaging has enabled simultaneous integration of the coronary anatomy with myocardial perfusion and metabolism and has improved characterization of dysfunctional areas in chronic CAD. Also, the availability of quantitative myocardial blood flow (MBF) evaluation with various PET perfusion tracers provides additional prognostic information and enhances the diagnostic performance of nuclear imaging.

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PET/MRI: Current state of the art and future potential for cardiovascular applications

Cited by 26 publications

References 66 publications

MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction

MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction

Clinical Implication of PET/MR Imaging in Preoperative Esophageal Cancer Staging: Comparison with PET/CT, Endoscopic Ultrasonography, and CT

Positron Emission Tomography in the Diagnosis and Management of Coronary Artery Disease

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