PET/MRI in colorectal and anal cancers: an update

Jayaprakasam, Vetri Sudar; Ince, Semra; Suman, Garima; Nepal, Pankaj; Hope, Thomas A.; Paspulati, Raj Mohan; Fraum, Tyler J.

doi:10.1007/s00261-023-03897-y

Cited by 4 publications

(3 citation statements)

References 81 publications

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“…The examination of the use of FDG PET MRI versus CT and its inherent role in the diagnosis of ASCC may also prove clinically useful in the future. 33 Considering previous literature on the topic 11,34 we agree that FDG PET-CT has a potential role in the prognostic assessment of patients with ASCC. This current review is the first to specifically examine prognostic value of pre-and post-FDG PET-CT in ASCC patients alone.…”

Section: Discussionmentioning

confidence: 64%

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Pre‐ and post‐treatment FDG PET‐CT as a predictor of patient outcomes in anal squamous cell carcinoma: A systematic review and meta‐analysis

Mac Curtain,

Qian,

Bell

et al. 2023

J Med Imag Rad Onc

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Anal squamous cell carcinoma (ASCC) has a generally acceptable outlook in terms of survival. 18‐fluorodeoxyglucose‐positron emission tomography/computer tomography (FDG PET‐CT) is not recommended for routine monitoring post‐ASCC treatment. We examine herein if FDG PET‐CT has a use in the prognostic evaluation of patients with ASCC, what FDG PET‐CT metrics are of value and if a pre‐ or post‐chemo/radiotherapy scan is more prognostic of outcomes. PubMed, EMBASE and Cochrane Central Registry of Controlled Trials were comprehensively searched until 3 May, 2023. A modified Newcastle Ottawa scale was used to assess for study bias. We present our systematic review alongside pooled hazard ratios (HR) for maximum standardised uptake values (SUV) as a predictor of overall survival (OS) and progression‐free survival (PFS). Seven studies including 523 patients were included in our systematic review. Current evidence suggests that SUV maximum and median, metabolic tumour volume, total lesion glycolysis and complete and partial metabolic response may be prognostic when considering overall or progression‐free survival (OS)/(PFS) along with local recurrence (LR). Pooled HR from two included studies indicate SUV max is prognostic of OS, HR 1.179, CI (1.039–1.338), P = 0.011 and PFS 1.176, CI (1.076–1.285), P < 0.01. FDG PET‐CT may have a role to play in the prognostic evaluation of ASCC patients. Current evidence suggests post‐treatment scanning may hold superior prognostic value at this time.

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Section: Discussionmentioning

confidence: 64%

“…As well as this, the superior prognostic value of post‐treatment FDG PET‐CT should be confirmed. The examination of the use of FDG PET MRI versus CT and its inherent role in the diagnosis of ASCC may also prove clinically useful in the future 33 …”

Section: Discussionmentioning

confidence: 99%

Pre‐ and post‐treatment FDG PET‐CT as a predictor of patient outcomes in anal squamous cell carcinoma: A systematic review and meta‐analysis

Mac Curtain,

Qian,

Bell

et al. 2023

J Med Imag Rad Onc

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“…This combined imaging modality can also spare patients the radiation exposure associated with the CT component of PET/CT. PET/MRI achieves a high softtissue contrast that is useful for delineating local tumor extent, and it can be implemented with 'functional' MR sequences such as diffusion-weighted imaging (DWI) [61].…”

Section: New Techniques and Applicationsmentioning

confidence: 99%

Medical Radiology: Current Progress

Pepe,

Crimì,

Vernuccio

et al. 2023

Diagnostics

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Recently, medical radiology has undergone significant improvements in patient management due to advancements in image acquisition by the last generation of machines, data processing, and the integration of artificial intelligence. In this way, cardiovascular imaging is one of the fastest-growing radiological subspecialties. In this study, a compressive review was focused on addressing how and why CT and MR have gained a I class indication in most cardiovascular diseases, and the potential impact of tissue and functional characterization by CT photon counting, quantitative MR mapping, and 4-D flow. Regarding rectal imaging, advances in cancer imaging using diffusion-weighted MRI sequences for identifying residual disease after neoadjuvant chemoradiotherapy and [18F] FDG PET/MRI were provided for high-resolution anatomical and functional data in oncological patients. The results present a large overview of the approach to the imaging of diffuse and focal liver diseases by US elastography, contrast-enhanced US, quantitative MRI, and CT for patient risk stratification. Italy is currently riding the wave of these improvements. The development of large networks will be crucial to create high-quality databases for patient-centered precision medicine using artificial intelligence. Dedicated radiologists with specific training and a close relationship with the referring clinicians will be essential human factors.

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Comparison of the TNM9th and 8th editions for localized and locally advanced anal squamous cell carcinoma treated nonsurgically and proposal of a new stage grouping system

Zheng,

Wang,

et al. 2024

Cancer Medicine

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ObjectiveTo compare the survival discrimination of the TNM9th and 8th editions for localized and locally advanced anal squamous cell carcinoma (ASCC) treated nonsurgically and suggest a simple revised staging system with data from the Surveillance, Epidemiology, and End Results (SEER) database.MethodsOverall survival (OS) was the primary endpoint. Survival comparisons between the T and N stages and the different staging systems were performed using the Kaplan–Meier method and log‐rank test, followed by correlation analysis and variable importance analysis (VIA). Additionally, multivariate analysis was employed to identify significant predictors, which were further visualized using a nomogram. Finally, calibration curve, C‐index, and decision curve analysis (DCA) were applied to assess the performance of the different staging systems.ResultsA total of 5384 patients with ASCC were analyzed, revealing superior discrimination OS by the TNM9th edition compared to that by the TNM8th edition. Multivariate analysis identified the T and N stages as significant OS predictors (all p < 0.001). However, ambiguity persisted in stage III subgroups within the TNM9th edition, showing OS times of 102 months for stage IIIA disease, 88 months for stage IIIB disease, and 128 months for stage IIIC disease (all p > 0.05). Correlation analysis demonstrated an increased correlation for the T stage between the TNM8th and 9th editions (ρ value from 0.7 to 0.89), while the N stage correlation decreased (ρ value from 0.84 to 0.56). VIA and the prognostic nomogram highlighted the greater importance of the T stage over the N stage. Based on these findings, a new staging system was developed, and its clinical utility was confirmed through calibration curves, C‐index values (from 0.598 to 0.604), and DCAs.ConclusionsOur new staging system exhibited slightly better prognostic value compared to the TNM9th staging systems for nonmetastatic ASCC and warrants further validation.

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PET/MRI in colorectal and anal cancers: an update

Cited by 4 publications

References 81 publications

Pre‐ and post‐treatment FDG PET‐CT as a predictor of patient outcomes in anal squamous cell carcinoma: A systematic review and meta‐analysis

Pre‐ and post‐treatment FDG PET‐CT as a predictor of patient outcomes in anal squamous cell carcinoma: A systematic review and meta‐analysis

Medical Radiology: Current Progress

Comparison of the TNM9th and 8th editions for localized and locally advanced anal squamous cell carcinoma treated nonsurgically and proposal of a new stage grouping system

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