PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?

Glaudemans, Andor W J M; Quintero, A.; Signore, Alberto

doi:10.1007/s00259-012-2060-9

Cited by 78 publications

(54 citation statements)

References 24 publications

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“…The outstanding role of PET imaging in detecting biochemical and molecular changes much earlier, before structural changes or clinical symptoms appear, has been described in numerous studies (55)(56)(57). fMR with DWI and MR spectroscopy has become an important noninvasive and nonradioactive tool for measuring brain activity by detecting, for instance, hemodynamic changes (in blood oxygenation and flow) induced by regional changes in neuronal activity (1,58). Numerous PET tracers, mostly 18 F-or 11 C-labeled radiopharmaceuticals, are available to assess different aspects of brain function.…”

Section: Potential Applications In Neuroimagingmentioning

confidence: 99%

“…Obviously, apparent diffusion coefficient values may also be helpful for assessing the degree of inflammation in Crohn disease because distinguishing fibrotic and inflammatory bowel strictures is usually difficult. Thus, the approach of combined PET/MR with various MR techniques may be beneficial for the accurate detection and monitoring of disease activity in inflammatory bowel disease, especially when complementary imaging is needed to characterize intestinal lesions (1,76).…”

Section: Smentioning

confidence: 99%

“…Because ALARA (as low as reasonably achievable) principles should be considered for all imaging studies, one of the most important reasons for establishing PET/MR in pediatric patients is that PET/MR has a lower radiation burden than PET/CT (1,7,8). This fact may be especially significant for pediatric cancer patients, who may need to undergo repeated diagnostic imaging sessions.…”

mentioning

confidence: 99%

“…However, hybrid imaging is also expected to lead to deeper insights into the dynamics and characteristics of tumoral or inflammatory processes (1)(2)(3). Thus, PET/MR will provide new perspectives for noninvasive imaging in clinical management and research (4).…”

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confidence: 99%

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Potential Pediatric Applications of PET/MR

et al. 2014

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Medical imaging with multimodality and whole-body technologies has continuously improved in recent years. The advent of combined modalities such as PET/CT and PET/MR offers new tools with an exact fusion of molecular imaging and high-resolution anatomic imaging. For noninvasive pediatric diagnostics, molecular imaging and whole-body MR have become important, especially in pediatric oncology. Because it has a lower radiation exposure than PET/CT, combined PET/MR is expected to be of special use in pediatric diagnostics. This review focuses on possible pediatric applications of PET/MR hybrid imaging, particularly pediatric oncology and neurology but also the diagnosis of infectious or inflammatory diseases.

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Section: Potential Applications In Neuroimagingmentioning

confidence: 99%

Section: Smentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Potential Pediatric Applications of PET/MR

et al. 2014

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“…[97] compared the measurement of disease activity with 18 F-FDG PET/CT with endoscopic biopsies and reported a sensitivity of 82% and specificity of 97%, using 18 F-FDG PET/CT and other studies have reported sensitivity of 85%-98% and specificity of 50%-89% [99101] . Combination of PET with FDG and MRI, have been shown to be useful for diagnostic evaluation of a variety of inflammatory processes and CD could be a candidate target of this novel technique [102] , with several advantages respect to PET/CT or SPECT/CT or MRI alone due to MRI excellent soft tissue contrast, diffusion weighted imaging, dynamic contrast enhanced imaging, fMRI and MR spectroscopy, improving the sensitivity and specificity of diagnosis and follow-up treatment monitoring the possibility of earlier response evaluation [64,103] . PET/MRI system can be either simultaneous or sequential.…”

Section: Indicationsmentioning

confidence: 99%

Current tecniques and new perpectives research of magnetic resonance enterography in pediatric Crohn’s disease

Masselli

Mastroiacovo

Marco

et al. 2016

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Crohn's disease affects more than 500000 individuals in the United States, and about 25% of cases are diagnosed during the pediatric period. Imaging of the bowel has undergone dramatic changes in the past two decades. The endoscopy with biopsy is generally considered the diagnostic reference standard, this combination can evaluates only the mucosa, not inflammation or fibrosis in the mucosa. Actually, the only modalities that can visualize submucosal tissues throughout the small bowel are the computed tomography (CT) enterography (CTE) with the magnetic resonance enterography (MRE). CT generally is highly utilized, but there is growing concern over ionizing radiation and cancer risk; it is a very important aspect to keep in consideration in pediatric patients. In contrast to CTE, MRE does not subject patients to ionizing radiation and can be used to detect detailed morphologic information and functional data of bowel disease, to monitor the effects of medical therapy more accurately, to detect residual active disease even in patients showing apparent clinical resolution and to guide treatment more accurately.

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