PET standardized uptake values of primary lung cancer for comparison with tumor volume doubling times

Siddique, Maham; Yip, Rowena; Henschke, Claudia I.; Yankelevitz, David F.

doi:10.1016/j.clinimag.2020.11.048

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Our results are similar, fibrosis is a risk factor for lung cancer yet squamous cell cancer had only a slightly more rapid doubling time in fibrotic versus non-fibrotic lung, adenocarcinoma was not significantly different. Our results complimented Siddique et al with histology as the predominant driver of tumor doubling time [28].…”

Section: Discussionsupporting

confidence: 91%

Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT

Salvatore,

Liu,

Peng

et al. 2024

J Transl Med

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Purpose Evaluate the behavior of lung nodules occurring in areas of pulmonary fibrosis and compare them to pulmonary nodules occurring in the non-fibrotic lung parenchyma. Methods This retrospective review of chest CT scans and electronic medical records received expedited IRB approval and a waiver of informed consent. 4500 consecutive patients with a chest CT scan report containing the word fibrosis or a specific type of fibrosis were identified using the system M*Model Catalyst (Maplewood, Minnesota, U.S.). The largest nodule was measured in the longest dimension and re-evaluated, in the same way, on the follow-up exam if multiple time points were available. The nodule doubling time was calculated. If the patient developed cancer, the histologic diagnosis was documented. Results Six hundred and nine patients were found to have at least one pulmonary nodule on either the first or the second CT scan. 274 of the largest pulmonary nodules were in the fibrotic tissue and 335 were in the non-fibrotic lung parenchyma. Pathology proven cancer was more common in nodules occurring in areas of pulmonary fibrosis compared to nodules occurring in areas of non-fibrotic lung (34% vs 15%, p < 0.01). Adenocarcinoma was the most common cell type in both groups but more frequent in cancers occurring in non-fibrotic tissue. In the non-fibrotic lung, 1 of 126 (0.8%) of nodules measuring 1 to 6 mm were cancer. In contrast, 5 of 49 (10.2%) of nodules in fibrosis measuring 1 to 6 mm represented biopsy-proven cancer (p < 0.01). The doubling time for squamous cell cancer was shorter in the fibrotic lung compared to non-fibrotic lung, however, the difference was not statistically significant (p = 0.24). 15 incident lung nodules on second CT obtained ≤ 18 months after first CT scan was found in fibrotic lung and eight (53%) were diagnosed as cancer. Conclusions Nodules occurring in fibrotic lung tissue are more likely to be cancer than nodules in the nonfibrotic lung. Incident pulmonary nodules in pulmonary fibrosis have a high likelihood of being cancer.

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Section: Discussionsupporting

confidence: 91%

Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT

Salvatore,

Liu,

Peng

et al. 2024

J Transl Med

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“…Recent studies reported that the volume doubling time (VDT) and mass doubling time (MDT) were effective to re ect the GNN growth and useful for the therapy decision-making [7][8][9][10][11] . But these studies mainly treated the growth rate of GGNs as a biomarker of re ecting the malignant potential of the tumor [12][13][14][15][16] , not focusing on the investigation of the relationships between the times (i.e., VDT and MDT) and the clinic features. Some studies are concerned with using VDT/MDT to evaluate the GGO growth.…”

Section: Introductionmentioning

confidence: 99%

The Natural Growth Rate of Growing Malignant Pulmonary Nodules with Ground-Glass Opacity and Association of Clinic Features With It

Xue

Duan

Zhang

et al. 2022

Preprint

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Objective The objective of the study was to investigate the volume (VDT) and mass doubling time (MDT) of growing malignant ground-glass opacity(GGO) and explore the relationships between doubling times and clinical-pathological features. Methods We collected 37 GGO cases (18 male & 19 female with age between 43- and 82-year-old) between 2016 and 2020 and all of these cases were along with growing malignant pulmonary nodules. The duration of follow-up and the variation in GGOs volume and mass were recorded. The morphologic changes and three-dimensional segmentation of GGO nodules were used to calculate the VDT and MDT based on a modified Schwartz model. The independent sample t-test was used to investigate the relationship between doubling times and their features. Logistic regression was used to evaluate the risk factors of growing malignant GGOs. Results The median follow-up time was 725 days (31-1507 days). The averaged VDT and MDT of the GGOs were 973 days and 671 days, respectively. Both VDT and MDT were significantly different among the three different groups of solid components of GGO(p<0.05). The vacuole sign and lepidic-predominant lung adenocarcinoma (LPA) also made an important role in changing the VDTs and MDTs (p<0.05). In addition, the growth of malignant pulmonary nodules was significantly associated with air bronchus sign (OR 6.667; 95% CI of 1.126-39.470; p=0.037). Multivariate analysis showed that LPA declined the GGOs growth (odds ratio 0.093, 95% CI of 0.011-0.765, p = 0.027). Conclusions The solid component of GGOs and vacuole sign were closely associated with the growth rate of GGOs. The GGOs with air bronchus sign was more dangerous in terms of growth rate than other GGO cases. However, the appearance of LPA could inhibit GGO growth. Further studies are still required to verify the obtained results.

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Comparison of lung cancer aggressiveness in patients who never smoked compared to those who smoked

et al. 2022

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PET standardized uptake values of primary lung cancer for comparison with tumor volume doubling times

Cited by 6 publications

References 26 publications

Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT

Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT

The Natural Growth Rate of Growing Malignant Pulmonary Nodules with Ground-Glass Opacity and Association of Clinic Features With It

Comparison of lung cancer aggressiveness in patients who never smoked compared to those who smoked

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