Petiveria alliacea exerts mnemonic and learning effects on rats

Silva, Mallone Lopes; Luz, Diandra Araújo; Paixão, Thiago Portal da; Silva, João Paulo Bastos; Belém-Filho, Ivaldo Jesus Almeida; Fernandes, Luanna Melo Pereira; Gonçalves, Ana Cristina Baetas; Fontes-Júnior, Enéas Andrade; Andrade, Marciene Ataíde de; Maia, Cristiane do Socorro Ferraz

doi:10.1016/j.jep.2015.04.005

Cited by 14 publications

(8 citation statements)

References 41 publications

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“…This test was used to assess learning and spatial memory, following a previously published protocol [ 32 , 84 ] adapted from Morris [ 85 ]. The task comprised a circular pool filled with water (25 °C) up to 30 cm, divided into four equal quadrants (Q1–Q4).…”

Section: Methodsmentioning

confidence: 99%

Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

Bittencourt

Silva

Aragão

et al. 2022

IJMS

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Hippocampus is the brain area where aluminum (Al) accumulates in abundance and is widely associated with learning and memory. In the present study, we evaluate behavioral, tissue, and proteomic changes in the hippocampus of Wistar rats caused by exposure to doses that mimic human consumption of aluminum chloride (AlCl3) in urban areas. For this, male Wistar rats were divided into two groups: Control (distilled water) and AlCl3 (8.3 mg/kg/day), both groups were exposed orally for 60 days. After the Al exposure protocol, cognitive functions were assessed by the Water maze test, followed by a collection for analysis of the global proteomic profile of the hippocampus by mass spectrometry. Aside from proteomic analysis, we performed a histological analysis of the hippocampus, to the determination of cell body density by cresyl violet staining in Cornu Ammonis fields (CA) 1 and 3, and hilus regions. Our results indicated that exposure to low doses of aluminum chloride triggered a decreased cognitive performance in learning and memory, being associated with the deregulation of proteins expression, mainly those related to the regulation of the cytoskeleton, cellular metabolism, mitochondrial activity, redox regulation, nervous system regulation, and synaptic signaling, reduced cell body density in CA1, CA3, and hilus.

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Section: Methodsmentioning

confidence: 99%

Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

Bittencourt

Silva

Aragão

et al. 2022

IJMS

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“…In this decade, however, the highest number ( n = 494) and density of citations (d = 35,3 per paper) stood out. In the following decade, with the publication of 23 papers [ 10 , 11 , 13 , 14 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ] and a greater diversity of methodological approaches, including a literature review and ex vivo methods, we verified a significantly smaller impact, reaching just over half of the citations ( n = 278) of the previous period and having a citation density (d = 12 per paper) three times lower.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the plant derivatives used in the studies, leaves [ 2 , 4 , 5 , 6 , 8 , 9 , 10 , 11 , 14 , 15 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 29 , 30 , 32 , 34 , 35 , 36 , 38 , 41 , 42 , 44 , 45 , 46 , 48 , 50 , 56 , 57 ], roots [ 7 , 16 , 33 , 37 , 39 , 43 , 47 , 49 , 51 , 52 , 53 , 55 ], and stems [ 16 , 21 , 24 , 26 , 36 , 37 , 39 , 45 , 49 , 51 , 58 ], respectively, we...…”

Section: Discussionmentioning

confidence: 99%

Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties

Conceição,

Silva,

Pantoja

et al. 2023

Plants

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Petiveria alliacea L. (Phytolaccaceae) holds significant importance in the Amazon region, where it has been traditionally utilized in folk medicine. In this study, we conducted a comprehensive bibliometric analysis using conventional metrics, combined with a critical content review of its pharmacological and toxicological properties, to identify gaps in the existing literature that require further investigation. Our investigation identified a total of 55 articles that met the inclusion criteria for this study. Remarkably, Brazil emerged as the primary contributor within the scope of this review, indicating a strong presence of research from this country. Furthermore, professional scientific societies have played a pivotal role in facilitating the dissemination of scientific findings through specialist journals, fostering the sharing of research work within the community. Analysis of keyword co-occurrence revealed that “Petiveria alliacea”, “plant extract”, and “guatemala” were the most frequently encountered terms, indicating their significance within the literature. In terms of study designs, in vivo and in vitro were the predominant types observed, highlighting their prevalence in this field of study. Our study also identified a lack in knowledge yet to be investigated.

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“…Estes estudos corroboram a indicação popular para picadas e dores em geral. Outro estudo in vivo foi realizado para avaliar a atividade antinociceptiva(GOMES et al, 2005), os efeitos sobre a cognição(SILVA et al, 2015). relatos das agentes da Pastoral da Saúde, esta espécie pode ser utilizada para o fígado/estômago, gases, diurético, na regulação do intestino, azia, gordura no fígado, diabetes e infecção urinária.Foi realizado um estudo in vivo para avaliar a atividade antiartrite e toxicidade do extrato aquoso de Baccharis, onde reduziu a severidade da artrite e não apresentou nenhum sinal de toxicidade no fígado ou rim, bem como não alterou perfil glicêmico e sua atividade gastroprotetora,Lívero et al, 2016b, verificaram que o extrato de B. trimera reduziu a área de lesão e o estresse oxidativo induzido por consumo agudo e crônico de etanol, entretanto, não protegeu a depleção da mucosa da parede gástrica e não alterou o volume de secreção, pH ou acidez total no modelo de ligadura pilórica.…”

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Hidrocarbonetos Aromáticos Policíclicos Nos Alimentos E Seu Efeito Tóxico: Uma Revisão

Carvalho¹,

Costa²,

Ribeiro³

et al. 2019

Ciências Da Saúde: Da Teoria À Prática 11

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Petiveria alliacea exerts mnemonic and learning effects on rats

Cited by 14 publications

References 41 publications

Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties

Hidrocarbonetos Aromáticos Policíclicos Nos Alimentos E Seu Efeito Tóxico: Uma Revisão

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