Peto's paradox: Nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic review

Perillo, Matteo; Silla, Alessia; Punzo, Angela; Caliceti, Cristiana; Kriete, Andres; Sell, Christian; Lorenzini, Antonello

doi:10.1016/j.bj.2023.100654

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…shed light on the negative relationship between cellular immortalization, the ability of cells to evade senescence and proliferate indefinitely, and species body mass [ 16 ]. Expanding on this, their latest review delves deeper into Peto's paradox, exploring the evolutionary adaptations that enable species to evolve longevity despite large body mass, while also addressing strategies to mitigate cancer risk in long-lived organisms [ 17 ].…”

Section: Also In This Issuementioning

confidence: 99%

Aging like fine wine: Mischievous microbes and other factors influencing senescence

Kattner

2024

Biomedical Journal

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Section: Also In This Issuementioning

confidence: 99%

Aging like fine wine: Mischievous microbes and other factors influencing senescence

Kattner

2024

Biomedical Journal

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“…Soft tissue tumours are rarely preserved in fossils, and even when present, they may not be recognisable as cancer [126].…”

Section: Cancer Through Timementioning

confidence: 99%

Ancient Diseases in Vertebrates: Tumours through the Ages

Garcês,

Pires,

Garcês

2024

Animals

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Paleo-oncology studies neoplastic diseases in fossilised animals, including human remains. Recent advancements have enabled more accurate diagnoses of ancient pathologies despite the inherent challenges in identifying tumours in fossils—such as the rarity of well-preserved specimens, the predominance of bone remains, and the difficulty in distinguishing neoplastic from non-neoplastic lesions. This study compiles reports of tumours in fossilised animals, highlighting that neoplasms are present in a wide range of vertebrates and drawing comparisons to modern instances of similar diseases. The findings underscore the multifactorial aetiology of tumours, which involves genetic, environmental, and lifestyle factors, and suggest that tumours have been around for at least 350 million years.

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“…Therefore, most of the papers of interest are found by the reviewers in the initial part of the abstract screening. In this case, following the example of Perillo et al [13] a two-fold stopping rule for this phase of screening was established: screening was stopped if more than 80 irrelevant papers in a batch of 100 papers were found (stopping rule #1) or when the screeners had performed 8 h of screening each (stopping rule #2), whichever happened first.…”

mentioning

confidence: 99%

Bile Acids and Bilirubin Role in Oxidative Stress and Inflammation in Cardiovascular Diseases

Punzo,

Silla,

Fogacci

et al. 2024

Diseases

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Bile acids (BAs) and bilirubin, primarily known for their role in lipid metabolism and as heme catabolite, respectively, have been found to have diverse effects on various physiological processes, including oxidative stress and inflammation. Indeed, accumulating evidence showed that the interplay between BAs and bilirubin in these processes involves intricate regulatory mechanisms mediated by specific receptors and signaling pathways under certain conditions and in specific contexts. Oxidative stress plays a significant role in the development and progression of cardiovascular diseases (CVDs) due to its role in inflammation, endothelial dysfunction, hypertension, and other risk factors. In the cardiovascular (CV) system, recent studies have suggested that BAs and bilirubin have some opposite effects related to oxidative and inflammatory mechanisms, but this area of research is still under investigation. This review aims to introduce BAs and bilirubin from a biochemical and physiological point of view, emphasizing their potential protective or detrimental effects on CVDs. Moreover, clinical studies that have assessed the association between BAs/bilirubin and CVD were examined in depth to better interpret the possible link between them.

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Peto's paradox: Nature has used multiple strategies to keep cancer at bay while evolving long lifespans and large body masses. A systematic review

Cited by 5 publications

References 45 publications

Aging like fine wine: Mischievous microbes and other factors influencing senescence

Aging like fine wine: Mischievous microbes and other factors influencing senescence

Ancient Diseases in Vertebrates: Tumours through the Ages

Bile Acids and Bilirubin Role in Oxidative Stress and Inflammation in Cardiovascular Diseases

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