Petrochemical-related DNA damage in wild rodents detected by flow cytometry

Chromosomal Damage in Two Species of Aquatic Turtles (Emys orbicularis and Mauremys caspica) Inhabiting Contaminated Sites in Azerbaijan

“…FCM was used to estimate DNA content variation within red blood cells (RBC) of both European pond turtles (Emys orbicularis) and Caspian turtles (Mauremys caspica). This method has been shown to be an effective biomarker of chromosomal damage, caused by a variety of contaminants including PAHs, radionuclides, and some pesticides, in many wildlife studies McBee and Bickham, 1988;Dallas and Evans, 1990;George et al, 1991;Lamb et al, 1991Lamb et al, , 1995Bickham et al, 1992Bickham et al, , 1994Custer et al, 1994;Lingenfelser et al, 1997aLingenfelser et al, , 1997bLowcock et al, 1997;Theodorakis et al, 2001;Matson et al, in press). Of more importance to this study is the fact that flow cytometry data tend to correlate well with petroleum products and PAHs in particular (Bickham et al, 1998a;Custer et al, 2000).…”

Feasibility of micronucleus methods for monitoring genetic damage in two feral species of small mammals

“…Furthermore, relatively few studies employing genotoxicity end- points as indicators of exposure have been conducted with Peromyscus sp. [McBee et al, 1987;Tice et al, 1987;McBee and Bickham, 1988;Shaw-Allen and McBee, 1993]. A comparative evaluation of micronucleus induction by benzene in M. musculus and P. leucopus was reported in an abstract by Boucher et al [1987].…”

Functional and Ultrastructural Cell Pathology Induced by Fuel Oil in Cultured Dolphin Renal Cells

“…Mutagenic or teratogenic actions of crude petroleum, No. 2 fuel oil, or diesel oil extracts have in fact been reported by numerous workers (Pelroy et al, 1981;Ellenton, 1982;Lockard et al, 1982;Salmeen et al, 1982;Lower et al, 1983;McBee and Bickham, 1988;Bickham et al, 1998).…”

“…Environmental contamination with petroleum products has induced DNA damage in wild rodents (McBee and Bickham, 1988), hepatotoxicity in experimental mice (Leighton, 1990), and various clinical e!ects in free-ranging cattle (Khan et al, 1996). Naturally weathered samples of the Exxon Valdez crude oil administered orally to laboratory ferrets also induced limited toxicity (Stubble"eld et al, 1995).…”