Pets at birth do not increase allergic disease in at‐risk children

Lodge, Caroline; Lowe, Adrian J.; Gurrin, Lyle C.; Matheson, Melanie C.; Balloch, Anne; Axelrad, Christine; Hill, David; Hosking, C. S.; Rodrigues, Susan; Svanes, Cecilie; Abramson, Michael J.; Allen, Katrina J.; Dharmage, Shyamali C.

doi:10.1111/j.1365-2222.2012.04032.x

Cited by 39 publications

(27 citation statements)

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“…We did not detect any differences between children with recurrent wheezing or asthma with respect to the presence of domestic pets, particularly cats and dogs. This result appeared to exclude an effect of pet ownership on respiratory symptoms and was consistent with some previous findings [36]. However, it has been reported that exposure to cats during the first year of life is an independent risk factor for wheezing and asthma at the age of 7 years [37].…”

Section: Discussionsupporting

confidence: 91%

Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma

et al. 2014

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BackgroundAir pollution has many negative health effects on the general population, especially children, subjects with underlying chronic disease and the elderly. The aims of this study were to evaluate the effects of traffic-related pollution on the exacerbation of asthma and development of respiratory infections in Italian children suffering from asthma or wheezing compared with healthy subjects and to estimate the association between incremental increases in principal pollutants and the incidence of respiratory symptoms.MethodsThis prospective study enrolled 777 children aged 2 to 18 years (375 with recurrent wheezing or asthma and 402 healthy subjects). Over 12 months, parents filled out a daily clinical diary to report information about respiratory symptoms, type of medication used and healthcare utilization. Clinical data were combined with the results obtained using an air pollution monitoring system of the five most common pollutants.ResultsAmong the 329 children with recurrent wheezing or asthma and 364 healthy subjects who completed follow-up, children with recurrent wheezing or asthma reported significantly more days of fever (p = 0.005) and cough (p < 0.001), episodes of rhinitis (p = 0.04) and tracheitis (p = 0.01), asthma attacks (p < 0.001), episodes of pneumonia (p < 0.001) and hospitalizations (p = 0.02). In the wheezing/asthma cohort, living close to the street with a high traffic density was a risk factor for asthma exacerbations (odds ratio [OR] = 1.79; 95% confidence interval [CI], 1.13-2.84), whereas living near green areas was found to be protective (OR = 0.50; 95% CI, 0.31 -0.80). An increase of 10 μg/m3 of particulates less than 10 microns in diameter (PM10) and nitrogen dioxide (NO2) increased the onset of pneumonia only in wheezing/asthmatic children (continuous rate ratio [RR] = 1.08, 95% CI: 1.00-1.17 for PM10; continuous RR = 1.08, 95% CI: 1.01-1.17 for NO2).ConclusionsThere is a significant association between traffic-related pollution and the development of asthma exacerbations and respiratory infections in children born to atopic parents and in those suffering from recurrent wheezing or asthma. These findings suggest that environmental control may be crucial for respiratory health in children with underlying respiratory disease.

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Section: Discussionsupporting

confidence: 91%

Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma

et al. 2014

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“…In the same way poverty is linked with poor hygienic conditions. This might explain why our as well as other Latin American studies have shown lack of hygiene [12,40,51], exposure to farm animals [52] and pets [53] as risk factors for asthma and allergies while other studies – mainly European studies [54-56] – have indicated an inverse relationship between low level of hygiene and such diseases. Our findings cast doubts on whether differences in phenotype of asthma, rhinoconjunctivitis and eczema in Latin America [57-59] are really the main reason for the dissimilarity with prevalence in other parts of the world [60].…”

Section: Discussionmentioning

confidence: 82%

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Solis-Soto¹,

Patiño

Nowak

et al. 2013

Environ Health

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BackgroundIn recent years, the prevalence of asthma, rhinoconjunctivitis and eczema symptoms in childhood has considerably increased in developing countries including Bolivia, possibly due to changes in lifestyle, environmental and domestic factors. This study aimed to assess the association between environmental factors and asthma, rhinoconjuctivitis and eczema symptoms in school-aged children from Oropeza Province in Chuquisaca, Bolivia.MethodsA cross-sectional study was performed in 2340 children attending the fifth grade in 36 randomly selected elementary schools in Oropeza province. The prevalence of symptoms was determined using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Environmental factors were assessed by the ISAAC environmental questionnaire including questions related to exposure to pets, farm animals, indoor and outdoor pollution, presence of disease vectors at home and precarious household conditions. Generalized linear mixed-effects models were adjusted for age, sex and place of living.ResultsThirty seven percent of children reported that at least one of their parents smoked at home. Wood or coal was used as cooking fuel in 19% of the homes and 29% reported intense truck traffic on the street where they lived. With respect to hygiene conditions, 86% reported exposure to dogs, 59% exposure to cats and 36% regular contact to farm animals. More than one precarious household condition was reported by 8% of children. In the adjusted model exposure to dog (adjusted OR 1.4; CI 95% 1.0-1.9), cat (1.2; 1.0-1.5), farm animals (1.5; 1.2-1.8); intense truck traffic (1.3; 1.0-1.6), parents smoking at home (1.2; 1.0-1.5), presence of disease vectors at home (fourth quartile vs. first quartile: 1.6; 1.2-2.3) and two or more precarious household conditions (1.5; 1.0-2.2) were significantly associated with rhinoconjunctivitis symptoms. The associations were similar for asthma and eczema symptoms; however it did not reach the level of statistical significance for all items.ConclusionOur results support previous findings reported for poor communities especially in Latin America, showing that lower hygiene conditions did not have protective effect against asthma and rhinoconjunctivitis and eczema symptoms.

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“…Following the original report from Hesselmar and Bjorksten in 1998 that children raised in a house with a cat were less likely to be allergic to cats, there have been extensive publications related to this phenomenon (17, 32, 33). Many reports have confirmed the original observation, but with significant differences between the effects of cat and dog ownership (18, 20, 34).…”

Section: Discussionmentioning

confidence: 99%

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden

Perzanowski

Rönmark

James

et al. 2016

Journal of Allergy and Clinical Immunology

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Pets at birth do not increase allergic disease in at‐risk children

Abstract: Pets at birth either decreased or had no effect on allergic disease up to age 12. We found no evidence that exposure to cats or dogs at birth increases the risk of allergic disease in high-risk children.

Cited by 39 publications

References 50 publications

Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma

Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma

Association between environmental factors and current asthma, rhinoconjunctivitis and eczema symptoms in school-aged children from Oropeza Province – Bolivia: a cross-sectional study

Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden

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