Peut-on rétablir la tolérance au soi dans les maladies autoimmunes ?

Chatenoud, Lucienne; Bach, J.-F.

doi:10.4267/10608/2347

Cited by 1 publication

(1 citation statement)

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“…B cells are specialized in the production of antibodies against foreign molecules. 32 The results of this research showing an increase in acid phosphatase, total protein in the serum and in the lung homogenate, come in concordance with the results obtained by Sahu et al in 1982, 33 who recorded the same after the exposure of Sprague Dawley male rats to n-hexane by inhalation. Although Sahu et al in 1982 33 did report elevations in total proteins and acid phosphatase in bronchial lavage following n-hexane exposure, the overall levels seemed lower than those reported in the present study, and statistical analysis was not conducted.…”

Section: Discussionsupporting

confidence: 92%

Pulmonary Toxicity Induced by N-Hexane in Wistar Male Rats After Oral Subchronic Exposure

Bouakkaz

Khelili

Rebaï³

et al. 2018

Dose-Response

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Studies of pulmonary toxicity induced by oral exposure to n-hexane are very few, in contrast to those studying the exposure by inhalation. This research tackles the oral toxic effect of n-hexane solvent on the lungs after subchronic exposure of Wistar male rats at 300, 600, and 1200 mg/kg, respectively, each day for 8 weeks. The pneumotoxicity observed in this study was marked by an immune toxicity in the form of a significant increase in the levels of white blood cells, lymphocytes, granulocytes, and eosinophils, as well as a significant increase in relative and absolute lung weight in both groups treated at the doses of 600 and 1200 mg/kg. n-Hexane also resulted in a significant increase in serum total proteins and acid phosphatase in the 3 doses tested daily for 8 weeks. In addition, we found a significant increase in total protein and a decrease in glutathione at 600 and 1200 mg/kg, in the pulmonary homogenate. Furthermore, the rate of lipid peroxidation increased in the 3 doses tested. Histological findings revealed a pneumonia characterized by bronchopneumonia, fibronecrotic lesions, congestion, hemorrhage, type II pneumocyte hyperplasia, alveolar lesions, bronchial epithelium degradation, and inflammation.

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Section: Discussionsupporting

confidence: 92%