Peyer's Patch Dendritic Cells: Isolation and Functional Comparison with Murine Spleen Dendritic Cells

Spalding, David M.; Williamson, S I; McGhee, Jerry R.; Koopman, William J.

doi:10.1016/s0171-2985(84)80124-2

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…Although this route is assumed to lead to conventional T-cell priming to intestinal antigen, it is important to point out that PP DC may differ from their peripheral counterparts in phenotype and function (54)(55)(56)(57)(58), suggesting that presentation by these cells could have unusual immunological consequences in vivo.…”

Section: Fi) Practical Implications Of Mucosa-specific Recirculationmentioning

confidence: 99%

The anatomical basis of intestinal immunity

Mowat¹,

Viney²

1997

Immunological Reviews

443

312

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The lymphoid tissues associated with the intestine are exposed continuously to antigen and are the largest part of the immune system. Many lymphocytes are found in organised tissues such as the Peyer's patches and mesenteric lymph nodes, as well as scattered throughout the lamina propria and epithelium of the mucosa itself. These lymphocyte populations have several unusual characteristics and the intestinal immune system is functionally and anatomically distinct from other, peripheral compartments of the immune system. This review explores the anatomical and molecular basis of these differences, with particular emphasis on the factors which determine how the intestinal lymphoid tissues discriminate between harmful pathogens and antigens which are beneficial, such as food proteins or commensal bacteria. These latter antigens normally provoke immunological tolerance, and inappropriate responses to them are responsible for immunopathologies such as food hypersensitivity and inflammatory bowel disease. We describe how interactions between local immune cells, epithelial tissues and antigen-presenting cells may be critical for the induction of tolerance and the expression of active mucosal immunity. In addition, the possibility that the intestine may act as an extrathymic site for T-cell differentiation is discussed. Finally, we propose that, under physiological conditions, immune responses to food antigens and commensal bacteria are prevented by common regulatory mechanisms, in which transforming growth factor beta plays a critical role.

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Section: Fi) Practical Implications Of Mucosa-specific Recirculationmentioning

confidence: 99%

The anatomical basis of intestinal immunity

Mowat¹,

Viney²

1997

Immunological Reviews

443

312

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show abstract

“…DC modulate a number of T-and B cell properties in a tissue-specific fashion, such as Th1/Th2 bias (Everson et al 1998;Iwasaki and Kelsall 1999;Rissoan et al 1999) and antibody isotype switching (Sato et al 2003;Spalding and Griffin 1986;Spalding et al 1984). Recent work by several groups, including ours, has shown that DC are also responsible for the imprinting of tissue-specific homing potential.…”

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confidence: 82%

Gut-Associated Lymphoid Tissues

2006

Current Topics in Microbiology and Immunology

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confidence: 87%

“…PP-DC can affect B cell function in a tissue-specific fashion by promoting class-switching to IgA (Sato et al 2003;Spalding and Griffin 1986;Spalding et al 1984). Similarly, B cell exposure to RA induces class-switching to IgA (Tokuyama and Tokuyama 1999).…”

mentioning

confidence: 99%