Peyronie&amp;rsquo;s Disease: Prevalence and Association with Cigarette Smoking

Pera, Giuseppe; Pescatori, Edoardo S.; Calabrese, Massimo; Boffini, Alessandro; Colombo, Fulvio; Andriani, E; Natali, Alessandro; Vaggi, L; Catuogno, C.; Giustini, Marco; Taggi, Franco

doi:10.1159/000049830

Cited by 150 publications

(44 citation statements)

References 9 publications

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“…Our study shows that reducing plaque size and decreasing penile curvature are significantly more in non-smoker patients. Essentially, Pera et al detected significant correlation between cigarette smoking and PD (but not with other variables such as cardiovascular disease, diabetes, and hypertension) [19]. Smoking supports the oxidative and degenerative process that has been assumed to be pathogenic in PD.…”

Section: Discussionmentioning

confidence: 93%

“…Smoking supports the oxidative and degenerative process that has been assumed to be pathogenic in PD. It claims that eliminating smoking could be the first step in the primary prevention of PD and an important tool for reducing the damage or the progression of the disease [19]. Furthermore, cessation of smoking might decrease the risk of nodule formation in men who chronically use cavernous self-injection for ED.…”

Section: Discussionmentioning

confidence: 99%

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Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Çakan¹,

Demirel²,

Aldemir³

et al. 2006

Archives of Andrology

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This study was conducted to find out if smoking has an effect on the results of combination therapy with vitamin E and colchicines in patients with early-stage Peyronie's disease (PD). A total of 58 potent patients suffering from early-stage PD were included in the study (mean age 47.3 years, range 25-73 y). The time from onset of the disease was <6 months and no patient had ED. The patients with severe fibrotic or calcified plaques were not included in the study. Of the patients, 36 were smokers (Group 1) and 22 were non-smokers (Group 2). All the patients received vitamin E (800 IU daily) and colchicines (1 mg daily) for 6 months. Follow-up ranged from 5 to 13 months (mean 10.3 m). The combination therapy was effective and well tolerated in both groups. There were no significant differences between the two groups according to age, disease duration, related disease (diabetes, hypertension, hypercholesterolemia, and hypertriglyceridemia), plaque sizes, and plaque numbers. The resolution in pain and increase in penile curvature and plaque size were similar rates in both groups (p > 0.05), while decrease in penile curvature and plaque size were higher in Group 2 (p < 0.05). No patient discounted the therapy due to side effects. The oral combination therapy with vitamin E and colchicines appears to be an effective procedure in patients with early-stage PD and smoking may have worsening effects on the treatment results.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Çakan¹,

Demirel²,

Aldemir³

et al. 2006

Archives of Andrology

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“…Während in früheren Untersuchungen eine Häufigkeit von ca. 1% aller Männer angenommen wird [14], gehen neuere Studien von bis zu 10% aus [62,75,45]. Dies hängt wohl vor allem damit zusammen, dass in den älteren Untersuchungen fast ausschließlich die Angaben des Patienten als Grundlage für die Diagnosestellung dienten, während in den neueren Erhebungen weitgehend standardisierte Untersuchungsergebnisse die Basis bilden.…”

Section: Epidemiologieunclassified

Induratio penis plastica

Leiber

Wetterauer

2002

Reproduktionsmedizin

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“…На сегодняшний день распространенность бо-лезни Пейрони оценивают среди всех взрослых мужчин в диапазоне от 3 до 8 % [3][4][5]. При этом от-мечается, что заболевание может не всегда сопро-вождаться клинической симптоматикой, которая требует лечения.…”

Section: Introductionunclassified

Assesment of the efficiency of conservative treatment of Peyronie’s disease

et al. 2018

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There were 27 men under observation who got conservative treatment for Peyronie's disease. The criteria for inclusion in the study were the maximum size of the plaque of the penis up to 1.5 cm and the angle of curvature of the penis is less than 45 degrees. Before treatment, after 6 and 12 months, patients underwent ultrasonic dopplerography of the penis, the velocity of blood flow in the cavernous and dorsal arteries and the size of the plaque were determined. All observed patients were prescribed combined therapy, such as symptomatic, immunological and physiotherapeutic treatment. In this case, the patients of the 1st group (n = 15) additionally got longidase treatment (intramuscularly for 3000 IU every 3 days, for a course of 10 injections with concurrent administration of rectal suppositories with longidase at the same dose for a course of 10 suppositories). Locally, these patients were assigned phonophoresis with lengidase on the plaque area (10 sessions). The remaining 12 patients (2nd group) didn’t got longidase treament. Six months after the start of treatment the absence of plaques was recorded in 8 (53.3%) patients in the 1st group and 4 (33.3%) in the 2nd group of patients and in 12 months in 11 (73.3%) and 6 (41.6%) patients. Thus, conservative therapy in Peyronie's disease is effective in patients in the early stages of the disease with moderate deviation of the penis and plaques up to 1.5 cm. The inclusion of longidase in the complex therapy increases the effectiveness of the treatment. (For citation: Kalinina SN, Fesenko VN, Nikolskii AV, et al. Assesment of the efficiency of conservative treatment of Peyronie’s disease. Urologicheskie vedomosti. 2018;8(1):5-10. doi: 10.17816/uroved815-10).

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Peyronie’s Disease: Prevalence and Association with Cigarette Smoking

Cited by 150 publications

References 9 publications

Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Induratio penis plastica

Assesment of the efficiency of conservative treatment of Peyronie’s disease

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