Peyronie's disease in a patient after COVID‐19 infection: A case report

Rainer, Quinn; Molina, Manuel; Ibrahim, Emad; Saltzman, Russell G.; Masterson, Thomas A.; Ramasamy, Ranjith

doi:10.1111/and.14219

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…SARS‐CoV‐2 can impair endothelial function and cause rare penile complications such as Mondor's disease in penis even a month after recovery, which emphasize a suspecting thrombosis among patients with paradoxically mild COVID‐19 13 . A hypothesis for endothelial dysfunction in ED was low endothelial progenitor cells, and flow‐mediated vasodilation may be the driving pathology 17 . Another hypothesis, a lower endothelial nitric oxide synthase, was a driver for ED after SARS‐CoV‐2 infection 6 …”

Section: Discussionmentioning

confidence: 99%

“…13 A hypothesis for endothelial dysfunction in ED was low endothelial progenitor cells, and flow-mediated vasodilation may be the driving pathology. 17 Another hypothesis, a lower endothelial nitric oxide synthase, was a driver for ED after SARS-CoV-2 infection. 6 However, whether or not, the continued SARS-CoV-2 presence of virus directly affects patients' health, or their reproductive health is not known.…”

Section: Discussionmentioning

confidence: 99%

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Evidence for residual SARS‐CoV‐2 in corpus cavernosum of patients who recovered from COVID‐19 infection

et al. 2022

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Background The COVID‐19 is an ongoing health problem with millions of cases and deaths worldwide. Although the virus is transmitted with droplets through the respiratory system, the involvement of different organs has been reported. Objectives The pandemic caused urological procedures to be postponed when patient is infected with SARS‐CoV‐2. However, the reliability of 1 month postpone period and long‐term complications of the virus, such as a possible erectile dysfunction (ED) is not clarified. We aimed to compare the corpus cavernosum of patients 1 and 7 months after COVID‐19 infection with control patients who had not COVID‐19 and search for SARS‐CoV‐2 in tissues using immunohistochemistry and electron microscopy. Materials and methods Three groups of subjects underwent penile prosthesis implantation and Nesbit procedure for Peyronie's disease 1 and 7 months after COVID‐19 infection and control group without previous COVID‐19 infection. We searched for SARS‐CoV‐2 in penile tissue using RT‐PCR, electron microscopy and immunohistochemistry. Results Electron microscopy and immunohistochemical staining showed SARS CoV‐2 virus in the penile corpus cavernosum of patients 1 month after COVID‐19 recovery. Immunohistochemical staining intensity correlated with the severity of previous infection. Transmission electron microscopy revealed intracellular virtual particles of about 80 nm with a typical morphology of prominent spikes and electron‐dense dots of nucleocapsid in addition to vesicles filled with virus‐like particles. Cells showed increased membrane trafficking. The 1 month after COVID‐19 group showed an increased number of fibroblasts. The 7 months after COVID‐19 group had similar morphology and immunoreactivity as control group. Discussion This is the first study of late post‐COVID examination of penis and the second study of early post‐COVID examination of corpus cavernosum. For 1 month post‐COVID patients, the aetiology of ED could be the viral infection that is also affecting corpora cavernosa. We hypothesize that viral infection affects the endocytic and exocytic pathways, hence the metabolic activity of cells that can be the reason of altered functions in some post‐COVID patients. Conclusion This study is important because it did not detect any virus residue in the tissue samples at the seventh month. In addition, we can say that the penile surgeries should be postponed more than 1 month after the COVID infection according to this study. But, there is a need for new studies with large series and high levels of evidence that can show how long the virus remains in the corpus cavernosum. Patients should be followed in this respect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evidence for residual SARS‐CoV‐2 in corpus cavernosum of patients who recovered from COVID‐19 infection

et al. 2022

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“…Male reproductive organs contain a substantially greater number of ACE2 receptors than female reproductive system organs [8,9]. Because of the ample expression of ACE2 receptors in the penis (especially corpus cavernosum) and testis, the male reproductive system is vulnerable to the effects of COVID-19 infection, thus affecting the sexual health and fertility of men [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Panner Selvam,

Kapoor,

Baskaran

et al. 2023

Clinics and Practice

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The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA (n = 72), Italy (n = 55), and China (n = 51). Such research was mainly focused around medicine (57.1%), followed by biochemistry, genetics, and molecular biology (25.7%). Also, in the area of male reproduction, only 37.1% (n = 128) of the articles contributed towards original research, whereas 52.8% (n = 182) were review articles and editorials focusing more on sexual dysfunction than infertility. Such a small number of studies published on COVID-19-related effects on male reproduction warrants a significant increase in research, which is required to decipher the mechanism(s) underlying SARS-CoV-2 infection-associated impairment of male reproductive function.

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Current insights and future directions in Peyronie's disease management: A narrative review

Howell,

Green,

Khalafalla

2024

UroPrecision

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Peyronie's disease (PD) is an inflammatory and fibrotic disease which results in disfiguring and often distressing penile curvature deformity, affecting up to one in nine men in the United States, and between 0.3% and 13.1% of men globally. It progresses through an acute phase, associated with pain, as the fibrosis develops. In the quiescent phase, penile pain ceases and deformity stabilizes. The precise etiology remains unknown despite ongoing work to elucidate the biological underpinning. The diagnosis is guided by history and physical examination. Except for ultrasonography, imaging is not routinely recommended. Current management is predicated on symptomatic control and slowing progression in the acute phase, and correction of bothersome curvature in the stable phase. Most nonsurgical treatment options are poorly supported by available evidence, with the exceptions of traction therapy and certain intralesional injections. Surgical treatment, considered only after stabilization, is guided by severity and the presence or absence of erectile function and is highly individualized. Investigations are ongoing into several areas, including the exact biological mechanisms leading to plaque formation and failure of resolution; the effects of co‐existing systemic disease; the role of imaging in diagnosis and surgical planning; combination and regenerative nonsurgical therapies; and improvements in surgical techniques. As diagnostic accuracy improves and targeted treatments become available, management of PD will become progressively tailored to an individual's particular disease. In this review, we summarize the current knowledge regarding PD, including etiology and epidemiology, diagnosis, management, cutting‐edge research, and future directions in care of this condition.

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Peyronie's disease in a patient after COVID‐19 infection: A case report

Cited by 4 publications

References 16 publications

Evidence for residual SARS‐CoV‐2 in corpus cavernosum of patients who recovered from COVID‐19 infection

Evidence for residual SARS‐CoV‐2 in corpus cavernosum of patients who recovered from COVID‐19 infection

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Current insights and future directions in Peyronie's disease management: A narrative review

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