PFAM catalyzed enantioselective diethylzinc addition to imines

Abstract

Chiral amines are important starting materials for the synthesis of biologically important compounds.Enantioselective addition of dialkylzinc reagents to imines is a reliable method for the synthesis of these compounds.Different chiral catalysts were developed and used for this method. Phosphorous based PFAM catalysts were tried for the first time in the enantioselective synthesis of amines by reacting diethylzinc with N-sulfonyl imines and Ndiphenylphosphinoyl imines. Chiral amines were isolated with moderate to acceptable yields and enantioselectivities.

Enantioselective Mannich Reaction Promoted by Chiral Phosphinoyl-Aziridines

“…The chiral phosphorus-functionalized aziridines have been marginally mentioned in the chemical literature [19][20][21][22][23]. Very recently, an enantioselective Michael addition promoted by chiral phosphinoyl-aziridines was published by our group [24].…”

Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines

“…Chiral phosphoroorganic compounds containing a three-membered ring of aziridine that act as ligands/organocatalysts in asymmetric synthesis are only rarely mentioned in the literature [28][29][30][31][32]. It should be pointed out that the successful application of phosphinoyl-aziridines as organocatalysts in the asymmetric Michael [33] and Mannich reaction [34] was reported in our department.…”