PFAS Biomonitoring in Higher Exposed Populations

Olsen, Geary W.

doi:10.1007/978-3-319-15518-0_4

Cited by 15 publications

(10 citation statements)

References 101 publications

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“…Fluorochemical production workers have in several studies been reported to have elevated exposure to PFASs. Most frequently, levels of PFOS and PFOA are presented, with mean concentrations typically in the range 500–7,000 ng/mL (Fromme et al., ), but also studies on PFHxS have been described with geometric mean concentrations up to 700 ng/mL (Olsen, ). In Olsen (), levels in fluorochemical production workers have been discussed in further detail.…”

Section: Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Risk to human health related to the presence of perfluoroalkyl substances in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

333

265

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The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluoroalkyl substances ( PFAS s) in food. Based on several similar effects in animals, toxicokinetics and observed concentrations in human blood, the CONTAM Panel decided to perform the assessment for the sum of four PFAS s: PFOA , PFNA , PFH xS and PFOS . These made up half of the lower bound ( LB ) exposure to those PFAS s with available occurrence data, the remaining contribution being primarily from PFAS s with short half‐lives. Equal potencies were assumed for the four PFAS s included in the assessment. The mean LB exposure in adolescents and adult age groups ranged from 3 to 22, the 95th percentile from 9 to 70 ng/kg body weight (bw) per week. Toddlers and ‘other children’ showed a twofold higher exposure. Upper bound exposure was 4‐ to 49‐fold higher than LB levels, but the latter were considered more reliable. ‘Fish meat’, ‘Fruit and fruit products’ and ‘Eggs and egg products’ contributed most to the exposure. Based on available studies in animals and humans, effects on the immune system were considered the most critical for the risk assessment. From a human study, a lowest BMDL 10 of 17.5 ng/ mL for the sum of the four PFAS s in serum was identified for 1‐year‐old children. Using PBPK modelling, this serum level of 17.5 ng/ mL in children was estimated to correspond to long‐term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake ( TWI ) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panel concluded that parts of the European population exceed this TWI , which is of concern.

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Section: Assessmentmentioning

confidence: 99%

“…Exposure can also occur through direct contact with consumer products such as all‐weather clothing and other textiles. In addition, PFAS manufacturing and downstream production may lead to occupational non‐dietary exposure to these compounds (Olsen, ).…”

Section: Assessmentmentioning

confidence: 99%

Risk to human health related to the presence of perfluoroalkyl substances in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

333

265

View full text Add to dashboard Cite

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“…See Figure 1 for a schematic of a typical multi-layered fabric for outdoor clothing. All of the above-mentioned concerns regarding PFASs in textile sector are leading to intensive research and high market demand of fluorine-free alternatives for DWOR finishing [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Biobased Waterborne Polyurethane-Urea/SWCNT Nanocomposites for Hydrophobic and Electrically Conductive Textile Coatings

Lacruz

Salvador²,

Blanco

et al. 2021

Polymers

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Waterborne polyurethane-urea dispersions (WPUD), which are based on 100% bio-based semi-crystalline polyester polyol and isophorone diisocyanate, have been successfully synthesized and doped with single-walled carbon nanotubes (SWCNT) to obtain a finishing agent that provides textiles with multifunctional properties. The chemical structure of WPUD has been characterized by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). The thermal properties have been evaluated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and dynamic mechanical thermal analysis (DMTA). Mechanical properties have been studied by tensile stress–strain analysis. Moreover, the particle size, particle size distribution (PSD), and stability of developed waterborne dispersions have been assessed by dynamic light scattering (DLS), Z-potential, and accelerated aging tests (analytical centrifugation). Subsequently, selected fabrics have been face-coated by the WPUD using knife coating method and their properties have been assessed by measuring water contact angle (WCA), water column, fabric stiffness, and air permeability. The electrical conductivity of textiles coated with SWCNT-doped WPUD has been evaluated by EN 1149 standard. Finally, the surface morphologies of uncoated and coated fabrics have been studied by scanning electron microscopy (SEM). All of the synthesized polyurethane-ureas provide the coated substrates with remarkable water-repellency and water column, being therefore a more sustainable alternative to waterproof coatings based on fluoropolymers, such as PTFE. The additivation of the polymeric matrices with SWCNT has led to textile coatings with excellent electrical conductivity, maintaining water column properties, giving rise to multifunctional coatings that are highly demanded in protective workwear and technical textiles.

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“…In areas with intense PFAS manufacturing and use, a priority area for research is to carry out adequately representative continuous human monitoring studies, including through the organisational and technical opportunity offered by neonatal screening Line 2531 Insert in Line 2564 Insert The workers of a fluorochemical plant in the Veneto Region (Italy) recently affected by a serious environmental contamination incident, also showed extremely high serum PFOA levels (in 2000: median 11.9, p75 32.0, maximum 86.3 ug/mL; in 2007: median 11.6, p75 18.7, maximum 47.0 ug/mL) (Costa, 2009). https://pubmed.ncbi.nlm.nih.gov/19225424-thirty-years-ofmedical-surveillance-in-perfluooctanoic-acid-productionworkers/ Justification A large area between the Provinces of Vicenza, Verona and Padua in the Veneto Region has been affected by an episode of drinking water and food supply chain pollution and human exposure, which has caused the largest documented episode Olsen, 2015(Olsen GW, 2015. Toxicological Effects of Perfluoroalkyl and Polyfluoralkyl Substances.…”

Section: Justificationmentioning

confidence: 99%

Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food

2020

EFSA Supporting Publications

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PFAS Biomonitoring in Higher Exposed Populations

Cited by 15 publications

References 101 publications

Risk to human health related to the presence of perfluoroalkyl substances in food

Risk to human health related to the presence of perfluoroalkyl substances in food

Biobased Waterborne Polyurethane-Urea/SWCNT Nanocomposites for Hydrophobic and Electrically Conductive Textile Coatings

Outcome of a public consultation on the draft risk assessment of perfluoroalkyl substances in food

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