PFAS Experts Symposium 2: PFAS Toxicology and Risk Assessment in 2021—Contemporary issues in human and ecological risk assessment of PFAS

Zodrow, Jeanmarie; Vedagiri, U.; Sorell, Tamara L.; McIntosh, L.P.; Larson, Emily; Hall, Linda C.; Dourson, Michael; Dell, Linda; Cox, Douglas; Barfoot, Krista; Anderson, Janet K.

doi:10.1002/rem.21706

Cited by 13 publications

(6 citation statements)

References 52 publications

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“…Based on several recent epidemiology surveillance studies, no consistent evidence of an increased risk between PFAS exposure and neurotoxicity had been observed [ 90 , 91 ]. However, in-depth studies at cellular and molecular levels ( Table 2 ) have shown that PFAS possess the potential to trigger and/or participate in pathways that may lead to neurobehavioral disorders, such as ADHD, fetal congenital cerebral palsy, memory dysfunction, learning disorders, and intellectual disability.…”

Section: Polyfluoroalkyl Substancesmentioning

confidence: 99%

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Jiang,

Guo

2024

Toxics

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This review presents a new perspective on the exacerbation of autism spectrum disorder (ASD) by per- and polyfluoroalkyl substances (PFAS) through the gut–liver–brain axis. We have summarized evidence reported on the involvement of the gut microbiome and liver inflammation that led to the onset and exacerbation of ASD symptoms. As PFAS are toxicants that particularly target liver, this review has comprehensively explored the possible interaction between PFAS and acetaminophen, another liver toxicant, as the chemicals of interest for future toxicology research. Our hypothesis is that, at acute dosages, acetaminophen has the ability to aggravate the impaired conditions of the PFAS-exposed liver, which would further exacerbate neurological symptoms such as lack of social communication and interest, and repetitive behaviors using mechanisms related to the gut–liver–brain axis. This review discusses their potential interactions in terms of the gut–liver–brain axis and signaling pathways that may contribute to neurological diseases.

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Section: Polyfluoroalkyl Substancesmentioning

confidence: 99%

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Jiang,

Guo

2024

Toxics

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“…The need for a comprehensive ecological risk assessment for PFAS calls for an improved understanding of their ecotoxicity. Several studies have concluded, however, that the current information on the ecotoxicity of PFAS is scattered, ambiguous, and strongly biased toward a limited spectrum of compounds and test organisms (ITRC, 2022; Van Keer et al, 2020; Zodrow et al, 2022). To address this knowledge gap, an analysis was conducted using data from studies spanning 2012 to 2022, focusing on algae, higher plants, fungi, amphibians, fish, insects, crustaceans, spiders, molluscs, worms, and other invertebrates.…”

Section: Ecotoxicity Of Pfasmentioning

confidence: 99%

Research Priorities for the Environmental Risk Assessment of Per‐ and Polyfluorinated Substances

Gkika,

Xie,

van Gestel

et al. 2023

Enviro Toxic and Chemistry

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Per‐ and polyfluorinated substances (PFAS) are a group of thousands ubiquitously applied persistent industrial chemicals. The field of PFAS environmental research is developing rapidly, but suffers from substantial biases towards specific compounds, environmental compartments, and organisms. The aim of this perspective was therefore to highlight current developments, and to identify knowledge gaps and subsequent research needs that would contribute to a comprehensive environmental risk assessment for PFAS. To this end, we consulted the open literature and databases, revealing that knowledge of the environmental fate of PFAS is based on the analysis of less than 1% of the compounds categorized as PFAS. Moreover, soils and suspended particulate matter (SPM) remain largely understudied. PFAS bioavailability, bioaccumulation and food web transfer studies also focus on a very limited number of compounds and are biased towards aquatic biota. Fish are predominantly studied, while aquatic invertebrates and macrophytes are included less frequently. The available ecotoxicity data revealed that only a few PFAS have been well‐studied for their environmental hazards, and that PFAS ecotoxicity data are strongly biased towards aquatic organisms as well. This emphasizes the need to catch up with ecotoxicity studies in the terrestrial environment. Considering the persistency and bioaccumulation of PFAS, more chronic, multigeneration and community ecotoxicity studies are needed. Finally, we identified the urgent need to unravel the relationship between sorption, bioaccumulation and ecotoxicity on the one hand and molecular descriptors of PFAS chemical structures and physicochemical properties on the other, to enable prediction of exposure, bioaccumulation and toxicity.

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“…90,91 PFAS also pose ecological risks through bioaccumulation, food chains, and toxicity in terrestrial and aquatic wildlife. 92…”

Section: Chemcomm Highlightmentioning

confidence: 99%

Advanced electrocatalytic redox processes for environmental remediation of halogenated organic water pollutants

Wilsey,

Taseska,

Meng

et al. 2023

Chem. Commun.

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PFAS Experts Symposium 2: PFAS Toxicology and Risk Assessment in 2021—Contemporary issues in human and ecological risk assessment of PFAS

Cited by 13 publications

References 52 publications

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Research Priorities for the Environmental Risk Assessment of Per‐ and Polyfluorinated Substances

Advanced electrocatalytic redox processes for environmental remediation of halogenated organic water pollutants

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