PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies

India-Aldana, Sandra; Yao, Meizhen; Midya, Vishal; Colicino, Elena; Chatzi, Leda; Chu, Jaime; Gennings, Chris; Jones, Dean P.; Loos, Ruth J.F.; Setiawan, Veronica Wendy; Smith, M. R.; Walker, Ryan W.; Barupal, Dinesh Kumar; Walker, Douglas I.; Valvi, Damaskini

doi:10.1007/s40726-023-00269-4

Cited by 25 publications

(2 citation statements)

References 239 publications

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“…Data from both mouse models and humans suggest that PFAS exposure affects breast tissue development and that the exposure has an impact on lactation. , It has been suggested that exposure to the PFAS can interrupt mammary gland development, as well as breast differentiation during late pregnancy and early lactation, and also change normal prolactin-family hormone secretion, which in turn is potentially linked with the detected reduction in breastfeeding duration due to PFAS exposure . In circulation, PFAS exposure has been associated with changes in metabolome, and particularly in the lipid profiles with changes reported in glycerophospholipid, linoleate/linoleic acid, sphingolipid, bile, and FA metabolism. This can potentially also be linked to the changes in the HBM composition.…”

Section: Resultsmentioning

confidence: 99%

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Hyötyläinen,

Ghaffarzadegan,

Karthikeyan

et al. 2024

Environ. Sci. Technol.

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The composition of human breast milk (HBM) exhibits significant variability both between individuals and within the same individual. While environmental factors are believed to play a role in this variation, their influence on breast milk composition remains inadequately understood. Herein, we investigate the impact of environmental factors on HBM lipid composition in a general population cohort. The study included mothers (All Babies In Southeast Sweden study) whose children later progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 9), celiac disease (n = 24), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), hypothyroidism (n = 6), and matched controls (n = 173). Lipidome of HBM was characterized by liquid chromatography combined with high-resolution mass spectrometry. We observed that maternal age, body mass index, diet, and exposure to perfluorinated alkyl substances (PFASs) had a marked impact on breast milk lipidome, with larger changes observed in the milk of those mothers whose children later developed autoimmune diseases. We also observed differences in breast milk lipid composition in those mothers whose offspring later developed autoimmune diseases. Our study suggests that breast milk lipid composition is modified by a complex interaction between genetic and environmental factors, and, importantly, this impact was significantly more pronounced in those mothers whose offspring later developed autoimmune/ inflammatory diseases. Our findings also suggest that merely assessing PFAS concentration may not capture the full extent of the impact of chemical exposures; thus, the more comprehensive exposome approach is essential for accurately assessing the impact of PFAS exposure on HBM and, consequently, on the health outcomes of the offspring.

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Section: Resultsmentioning

confidence: 99%

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Hyötyläinen,

Ghaffarzadegan,

Karthikeyan

et al. 2024

Environ. Sci. Technol.

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“…As such, recent meta-analyses also support a strong association between PFOA, PFNA, PFOS, and the risk of hyperuricemia. 137,138…”

Section: Serum Uric Acid and Hyperuricemiamentioning

confidence: 99%

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Schlezinger,

Gokce

2024

Circulation Research

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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Designer Anions for Better Rechargeable Lithium Batteries and Beyond

Song,

Wang,

Feng

et al. 2024

Advanced Materials

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Non‐aqueous electrolytes, generally consisting of metal salts and solvating media, are indispensable elements for building rechargeable batteries. As the major sources of ionic charges, the intrinsic characters of salt anions are of particular importance in determining the fundamental properties of bulk electrolyte, as well as the features of the resulting electrode‐electrolyte interphases/interfaces. To cope with the increasing demand for better rechargeable batteries requested by emerging application domains, the structural design and modifications of salt anions are highly desired. Here, salt anions for lithium and other monovalent (e.g., sodium and potassium) and multivalent (e.g., magnesium, calcium, zinc, and aluminum) rechargeable batteries are outlined. Fundamental considerations on the design of salt anions are provided, particularly involving specific requirements imposed by different cell chemistries. Historical evolution and possible synthetic methodologies for metal salts with representative salt anions are reviewed. Recent advances in tailoring the anionic structures for rechargeable batteries are scrutinized, and due attention is paid to the paradigm shift from liquid to solid electrolytes, from intercalation to conversion/alloying‐type electrodes, from lithium to other kinds of rechargeable batteries. The remaining challenges and key research directions in the development of robust salt anions are also discussed.This article is protected by copyright. All rights reserved

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PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies

Cited by 25 publications

References 239 publications

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Designer Anions for Better Rechargeable Lithium Batteries and Beyond

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