PFAS fluidize synthetic and bacterial lipid monolayers based on hydrophobicity and lipid charge

Naumann, Aleksandra; Alesio, Jessica; Poonia, Monika; Bothun, Geoffrey D.

doi:10.1016/j.jece.2022.107351

Cited by 11 publications

(4 citation statements)

References 43 publications

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“…30,32 Naumann et al took this a step further and specically looked at the membrane interactions using isolated membranes from Alcanivorax borkumenis and model phospholipid compounds of both mono-and bi-layer membranes. 28 They performed compressibility tests and found that while PFAS did cause lipid condensation, (i.e. caused the phospholipids to become more tightly packed), it still increased membrane uidity in all cases.…”

Section: Cellular Effectsmentioning

confidence: 99%

Bacterial transformation of per- and poly-fluoroalkyl substances: a review for the field of bioremediation

Lafond

Hatzinger²,

Guelfo

et al. 2023

Environ. Sci.: Adv.

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Section: Cellular Effectsmentioning

confidence: 99%

Bacterial transformation of per- and poly-fluoroalkyl substances: a review for the field of bioremediation

Lafond

Hatzinger²,

Guelfo

et al. 2023

Environ. Sci.: Adv.

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“…Eventually, epidemiological associations between exposure to PFAAs and prostate cancer mortality, hepatotoxicity, and lower infantile birthweight were illuminated, and their presence was reported in wildlife throughout the world . Increasing scientific evidence has highlighted the underlying link between PFAAs and their detrimental effects to the health of both wildlife and humans. ,− As of 2023, the US Environmental Protection Agency (EPA) is set to regulate the levels of six different types of PFAS (including PFOS and PFOA) in the US drinking water reservoirs . While the efforts are underway to find benign alternatives to the PFAAs, the Center for Disease Control (CDC) has revealed that PFAS are found in nearly every US citizen, and their use continues worldwide.…”

Section: Introductionmentioning

confidence: 99%

Surface Science View of Perfluoroalkyl Acids (PFAAs) in the Environment

Brahana,

Patel,

Bharti

2024

ACS Environ. Au

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Per-and polyfluoroalkyl substances (PFAS) constitute a notorious category of anthropogenic contaminants, detected across various environmental domains. Among these PFAS, perfluoroalkyl acids (PFAAs) stand out as a focal point in discussions due to their historical industrial utilization and environmental prominence. Their extensive industrial adoption is a direct consequence of their remarkable stability and outstanding amphiphilic properties. However, these very traits that have made PFAAs industrially desirable also render them environmentally catastrophic, leading to adverse consequences for ecosystems. The amphiphilic nature of PFAAs has made them highly unique in the landscape of anthropogenic contaminants and, thereby, difficult to study. We believe that well-established principles from surface science can connect the amphiphilic nature of PFAAs to their accumulation and transport in the environment. Specifically, we discuss the role of interfacial science in describing the stability, interfacial uptake (air−liquid and solid−liquid), and wetting capability of PFAAs. Surface science principles can provide new insights into the environmental fate of PFAAs, as well as provide context on their deleterious effects on both the environment and human health.

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“…4,5 Indeed, studies have reported levels over 1 μg/g of dust in some indoor environments, 5,6 representing >60% of total airborne exposure. 4 In addition to PFAS contaminants, these dust particles contain a variety of components including proteins�many of which tend to be allergens from common indoor sources such as dust mites or pet dander. These proteins are present on the μg/g scale 7 and can potentially act as carriers for hydrophobic molecules such as PFOA/PFOS, facilitating their delivery and incorporation into respiratory membranes.…”

Section: Introductionmentioning

confidence: 99%

“…PFOA and PFOS have low atmospheric volatility compared to short-chain PFAS. As such, dust particles represent both a major reservoir and an avenue of exposure for these compounds. , Indeed, studies have reported levels over 1 μg/g of dust in some indoor environments, , representing >60% of total airborne exposure . In addition to PFAS contaminants, these dust particles contain a variety of components including proteinsmany of which tend to be allergens from common indoor sources such as dust mites or pet dander.…”

Section: Introductionmentioning

confidence: 99%

Albumin Proteins as Delivery Vehicles for PFAS Contaminants into Respiratory Membranes

Pye,

Wallace,

Marangoni

et al. 2023

ACS Omega

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Poly- and perfluoroalkyl substances (PFAS) are a family of chemicals that have been used in a wide range of commercial products. While their use is declining, the prevalence of PFAS, combined with their chemical longevity, ensures that detectable levels will remain in the environment for years to come. As such, there is a pressing need to understand how PFAS contaminants interact with other elements of the human exposome and the consequences of these interactions for human health. Using serum albumin as a model system, we show that proteins can bind PFAS contaminants and facilitate their incorporation into model pulmonary surfactant systems and lipid bilayers. Protein-mediated PFAS delivery significantly altered the structure and function of both model membrane systems, potentially contributing to respiratory dysfunction and airway diseases in vivo. These results provide valuable insights into the synergistic interaction between PFAS contaminants and other elements of the human exposome and their potential consequences for human health.

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PFAS fluidize synthetic and bacterial lipid monolayers based on hydrophobicity and lipid charge

Cited by 11 publications

References 43 publications

Bacterial transformation of per- and poly-fluoroalkyl substances: a review for the field of bioremediation

Bacterial transformation of per- and poly-fluoroalkyl substances: a review for the field of bioremediation

Surface Science View of Perfluoroalkyl Acids (PFAAs) in the Environment

Albumin Proteins as Delivery Vehicles for PFAS Contaminants into Respiratory Membranes

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