Pfizer SARS-CoV-2 BNT162b2 mRNA vaccination (BNT162b2) has no adverse effect on elective oocyte cryopreservation outcomes

Karavani, Gilad; Chill, Henry H.; Dick, Aharon; Meirman, Cherut; Gutman-Ido, Einat; Herzberg, Shmuel; Ben‐Meir, Assaf; Imbar, Tal

doi:10.1016/j.rbmo.2022.06.001

Cited by 9 publications

(13 citation statements)

References 15 publications

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“…Karavani and colleagues compared 69 women who received BNT162b2 mRNA vaccine and 103 unvaccinated ones and found the vaccinated group had higher peak E2 concentrations. 19 In another cohort study, both the serum P levels among the BNT162b2 mRNA vaccinated and COVID-19 infected women showed a significant increase when compared to nonexposed group (p = 0.008). 20 This difference may be related to the relative immunogenic strength of vaccines produced by different methods.…”

Section: Discussionmentioning

confidence: 90%

Comprehensive evaluation of the effect of inactivated SARS‐CoV‐2 vaccination on female fertility: A retrospective cohort study

Ba,

Yang,

Zhu

et al. 2023

Journal of Medical Virology

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Fear of possible negative effects of coronavirus disease 2019 (COVID‐19) vaccine on fertility is the main reason for vaccine hesitancy among the public especially women of childbearing age. Despite the high coverage of COVID‐19 vaccination in China, more scientific evidence is still needed to address their concerns and guide fertility counseling and management in the future. Herein, we performed a retrospective cohort study at a single large center for reproductive medicine in China between August 2020 and May 2023. Patients aged 20–42 years with no history of laboratory‐confirmed COVID‐19 were included and categorized into different groups according to their vaccination status. The serum sex hormone levels, anti‐Müllerian hormone concentrations, embryo quality, and pregnancy outcomes were evaluated and compared among them. We found there were no significant differences in the concentrations of follicle‐stimulating hormone, luteinizing hormone and progesterone between the unvaccinated, first‐dose, second‐dose, and booster vaccinated groups. However, the estradiol showed a highly significant increase in the one‐dose vaccinated group compared with its levels in other groups. Among unvaccinated and either vaccinated patients, anti‐Müllerian hormone levels were comparable (p = 0.139). The number of oocytes retrieved, fertilization rate and good‐quality embryo rate were all similar between each group of in vitro fertilization and intracytoplasmic sperm injection. No significant differences were observed regarding other laboratory parameters. Moreover, the vaccination status of infertile couples did not exert any adverse effect on the pregnancy outcomes in all assisted reproductive technologies cycles. In short, we comprehensively evaluated the reproductive safety of inactivated severe acute respiratory syndrome coronavirus 2 vaccine and found any dose of vaccination wouldn't negatively affect female fertility parameters such as sex hormone levels and ovarian reserve. Moreover, this is the first study to complete the live birth follow‐up of the cohort after receiving inactivated severe acute respiratory syndrome coronavirus 2 vaccine, further dispelling the misconception and providing reassurance for decision‐making by clinicians.

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Section: Discussionmentioning

confidence: 90%

Comprehensive evaluation of the effect of inactivated SARS‐CoV‐2 vaccination on female fertility: A retrospective cohort study

Ba,

Yang,

Zhu

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

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“…We also analyzed data on whether COVID-19 vaccines affected the number of oocytes and MII/mature oocytes, blastocysts rate, and fertilization rate. Data on the number of oocytes from nine studies ( 18 , 19 , 22 , 24 – 28 , 33 ) were combined, and the difference was not statistically significant (MD: 0.12; 95% CI: −0.65–0.88; P = 0.77; Figure 6 ). Moreover, there was no statistically significant difference in the number of MII/mature oocytes between the vaccinated and unvaccinated groups from seven studies (MD: 0.27; 95% CI: −0.36–0.90; P = 0.40; Figure 7 ) ( 18 – 20 , 25 , 26 , 28 , 33 ).…”

Section: Resultsmentioning

confidence: 99%

“…Data on the number of oocytes from nine studies ( 18 , 19 , 22 , 24 – 28 , 33 ) were combined, and the difference was not statistically significant (MD: 0.12; 95% CI: −0.65–0.88; P = 0.77; Figure 6 ). Moreover, there was no statistically significant difference in the number of MII/mature oocytes between the vaccinated and unvaccinated groups from seven studies (MD: 0.27; 95% CI: −0.36–0.90; P = 0.40; Figure 7 ) ( 18 – 20 , 25 , 26 , 28 , 33 ). The rates of blastocyst formation ( 20 , 24 – 27 , 33 ) and fertilization ( 20 , 22 , 24 – 27 ) were also not significantly different between the vaccinated and unvaccinated groups (MD: 0.01 vs. 1.08; 95% CI: −0.04–0.06 vs. −0.57–2.73; P = 0.70 vs. P = 0.20, respectively; Figures 8 , 9 ).…”

Section: Resultsmentioning

confidence: 99%

“…The Q test and I 2 index of the number of oocytes ( P = 0.04, I 2 =51%) and MII/mature oocytes ( P = 0.33, I 2 =13%), blastocyst rate ( P = 0.42, I 2 =0%) and fertilization rate ( P = 0.16, I 2 =36%) showed low to moderate heterogeneity. The quality of the studies involved in the combined index is at a high level ( 18 – 20 , 22 , 24 – 28 , 33 ), as summarized in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Quality assessment NOS quality assessment scored more than or equal to 7 as high quality, 5-6 as medium quality, and <5 as low quality (38). Overall, 19 of the 20 cohort studies (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(32)(33)(34)(35)(36)(37) were of high quality (NOS score ≥7). The remaining study (31) was of relatively poor quality, as summarized in Table 2.…”

Section: Patient Characteristicsmentioning

confidence: 99%

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Effect of COVID-19 vaccination on the outcome of in vitro fertilization: A systematic review and meta-analysis

Zhang

Sun

Wang

et al. 2023

Front. Public Health

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BackgroundUniversal COVID-19 vaccination programs are now recommended in several countries and represent the most effective preventive measure against COVID-19. However, some reports suggest that vaccination may cause infertility or have adverse effects on pregnancy. Conflicting reports have led to vaccine hesitancy in women planning pregnancy.PurposeTo determine whether vaccination against COVID-19 affects in vitro fertilization (IVF) outcomes, we conducted a meta-analysis.MethodA systematic search was conducted using PubMed, Embase, MEDLINE, and Web of Science databases for all published literature on COVID-19 vaccines and outcomes of IVF. International Prospective Register of Systematic Reviews registration was completed on September 13, 2022 (CRD42022359771).ResultsWe analyzed 20 studies totaling 18,877 individual cases undergoing IVF. COVID-19 vaccination had significant effect on clinical and ongoing pregnancy rate (risk ratio (RR): 0.97; 95% confidence interval (CI): 0.94–0.99; RR: 0.93; 95% CI: 0.87–0.99). These outcomes did not differ between vaccinated and unvaccinated individuals: biochemical pregnancy rate (RR: 0.95; 95% CI: 0.88–1.03), implantation rate (RR: 1.02; 95%CI: 0.97–1.07; P = 0.41), the number of oocytes (mean difference (MD): 0.12; 95% CI: −0.65–0.88) and MII/mature oocytes recovered (MD: 0.27; 95% CI: −0.36–0.90), blastocysts rate (MD: 0.01; 95% CI: −0.04, 0.06), and fertilization rate (MD: 1.08; 95% CI: −0.57, 2.73).ConclusionOur findings suggest that vaccination against COVID-19 does not adversely affect the biochemical pregnancy rates; number of oocytes and MII/mature oocytes obtained; implantation, blastocysts; and fertilization rates in women undergoing IVF treatment. Subgroup analysis showed that the mRNA vaccine had no statistical significance on all indexes (clinical, biochemical, or ongoing pregnancy rates; implantation, blastocysts, or fertilization rates; and the number of oocytes and MII/mature oocytes). The findings of this meta-analysis are anticipated to increase the willingness of women planning IVF treatment to receive COVID-19 vaccination and provide evidence-based medical guidance for the development and implementation of guidelines.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022359771.

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Effect of female coronavirus disease 2019 vaccination on assisted reproductive outcomes: a systematic review and meta-analysis

Huang

Zheng

Liu

et al. 2023

Fertility and Sterility

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Pfizer SARS-CoV-2 BNT162b2 mRNA vaccination (BNT162b2) has no adverse effect on elective oocyte cryopreservation outcomes

Cited by 9 publications

References 15 publications

Comprehensive evaluation of the effect of inactivated SARS‐CoV‐2 vaccination on female fertility: A retrospective cohort study

Comprehensive evaluation of the effect of inactivated SARS‐CoV‐2 vaccination on female fertility: A retrospective cohort study

Effect of COVID-19 vaccination on the outcome of in vitro fertilization: A systematic review and meta-analysis

Effect of female coronavirus disease 2019 vaccination on assisted reproductive outcomes: a systematic review and meta-analysis

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