This article investigates the origins and significance of images of griffins and sphinxes—hybrid creatures of Greco-Roman tradition—in the marginal decorations of the so-called “Neapolitan Ovid” (BNN ms. IV F 3), the first illuminated manuscript of the Metamorphoses, probably from the late 11th century. Their form and style suggest specific iconographic origins and links with the decorative motifs from Antiquity that circulated in artistic objects around Bari, the manuscript’s place of origin. Among the many figures that provide a pictorial response to the poem’s content, the presence of these griffins and sphinxes offers compelling evidence of the survival of ancient imagery; they also invite us to explore the relationship between image and text in the illuminated book. From this analysis, we can better understand the complex role of these hybrid figures in the manuscript. Their existence is testimony to the continuity of marginal decorative systems derived from Antiquity that are present in objects and were articulated through the Islamic and Byzantine formal vocabularies accessible in Puglia at the time.