PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke

Zhang, Haitao; Du, Deyong; Gao, Xiaoning; Tian, Xiaoling; Xu, Yongqiang; Wang, Bo; Yang, Shoujuan; Liu, Pengfei; Li, Zefu

doi:10.1007/s10142-023-01237-3

Funct Integr Genomics

2023

DOI: 10.1007/s10142-023-01237-3

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PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke

Haitao Zhang,

Deyong Du,

Xiaoning Gao

et al.

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Cited by 3 publications

References 39 publications

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Wnt signalling pathways as mediators of neuroprotective mechanisms: therapeutic implications in stroke

Sharma,

Singh

2024

Mol Biol Rep

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Wnt signalling pathways as mediators of neuroprotective mechanisms: therapeutic implications in stroke

Sharma,

Singh

2024

Mol Biol Rep

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Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms

Yadava,

Reddy,

Nakka

et al. 2025

Neuroscience

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A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke

Moxon,

Pretorius,

Trollope

et al. 2024

J Cereb Blood Flow Metab

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Ischaemic stroke results in the formation of a cerebral infarction bordered by an ischaemic penumbra. Characterising the proteins within the ischaemic penumbra may identify neuro-protective targets and novel circulating markers to improve patient care. This review assessed data from studies using proteomic platforms to compare ischaemic penumbra tissues to controls following experimental stroke in animal models. Proteins reported to differ significantly between penumbra and control tissues were analysed in silico to identify protein-protein interactions and over-represented pathways. Sixteen studies using rat (n = 12), mouse (n = 2) or primate (n = 2) models were included. Heterogeneity in the design of the studies and definition of the penumbra were observed. Analyses showed high abundance of p53 in the penumbra within 24 hours of permanent ischaemic stroke and was implicated in driving apoptosis, cell cycle progression, and ATM- MAPK- and p53- signalling. Between 1 and 7 days after stroke there were changes in the abundance of proteins involved in the complement and coagulation pathways. Favourable recovery 1 month after stroke was associated with an increase in the abundance of proteins involved in wound healing. Poor recovery was associated with increases in prostaglandin signalling. Findings suggest that p53 may be a target for novel therapeutics for ischaemic stroke.

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PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke

Cited by 3 publications

References 39 publications

Wnt signalling pathways as mediators of neuroprotective mechanisms: therapeutic implications in stroke

Wnt signalling pathways as mediators of neuroprotective mechanisms: therapeutic implications in stroke

Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms

A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke

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