PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle

Geng, Tuoyu; Li, Ping; Okutsu, Mitsuharu; Yin, Xinhe; Kwek, Jyeyi; Zhang, Mei; Yan, Zhen

doi:10.1152/ajpcell.00481.2009

Cited by 225 publications

(217 citation statements)

References 54 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…The observed import of PPARGC1A into myonuclei upon sympathetic nerve stimulation is consistent with the transcriptional changes by SM postexercise (29). Because PPARGC1A is crucial in mitochondrial biogenesis (30), reduced mitochondrial protein synthesis postexercise after treatment with beta-blockers (31) could be explained as well. Because sympathetic input to skeletal muscles is via the sciatic nerve, various effects using sciatic denervation as an atrophy model might also have a sympathetic contribution.…”

Section: Discussionsupporting

confidence: 64%

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Khan

Lustrino

Silveira

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

132

155

View full text Add to dashboard Cite

The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make close contact with neuromuscular junctions and form a network in skeletal muscle that may functionally couple different targets including blood vessels, motor neurons, and muscle fibers. Direct stimulation of sympathetic neurons led to activation of muscle postsynaptic β2-adrenoreceptor (ADRB2), cAMP production, and import of the transcriptional coactivator peroxisome proliferator-activated receptor γ-coactivator 1α (PPARGC1A) into myonuclei. Electrophysiological and morphological deficits of neuromuscular junctions upon sympathectomy and in myasthenic mice were rescued by sympathicomimetic treatment. In conclusion, this study identifies the neuromuscular junction as a target of the sympathetic nervous system and shows that sympathetic input is crucial for synapse maintenance and function

show abstract

Section: Discussionsupporting

confidence: 64%

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Khan

Lustrino

Silveira

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

132

155

View full text Add to dashboard Cite

show abstract

“…Exercise can induce transformation of muscle fiber types to oxidative muscle fiber types, and the muscle fiber-type transformation was found to be blocked in AMPK-deficient mice (Wojtaszewski et al, 2000;Chen et al, 2003;Röckl et al, 2007;Geng et al, 2010). Long-term injection of AMPK agonists can regulate transformation of mouse muscle fiber type to oxidized muscle fiber types (Suwa et al, 2003;Ljubicic et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Comparisons of different myosin heavy chain types, AMPK, and PGC-1α gene expression in the longissimus dorsi muscles in Bama Xiang and Landrace pigs

Huang

Jiang

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Bama Xiang and Landrace pigs are the local fatty and lean breeds, respectively, in China. We compared differences in carcass traits, meat quality traits, and myosin heavy chain (MyHC) types in the longissimus dorsi muscles between Bama Xiang and Landrace pigs. This was done in pigs of the same age, using real-time PCR, to investigate the relationship between MyHC fiber types and carcass characteristics, meat quality traits, and the key factors regulating muscle fiber type. Bama Xiang pigs exhibited smaller size and slower growth than Landrace pigs (P < 0.01). We found that the superior meat quality, especially the high intramuscular fat (IMF) content in Bama Xiang pig, was related to elevated type I oxidative muscle fiber content (P < 0.01). In contrast, Landrace pig muscle had a higher glycolytic type IIb muscle fiber content (P < 0.01). MyHC I gene expression was significantly positively correlated with backfat thickness and IMF content (P < 0.01). MyHC IIb was significantly negatively correlated with IMF content (P < 0.05), and positively correlated with carcass yield (P < 0.05). AMP-activated protein kinase and peroxisome proliferatoractivated receptor-g coactivator-1a are suggested to be the two key factors regulating muscle fiber type in pigs. Our results indicate that muscle fiber composition is one of the key differences leading to the differences of meat quality between Bama Xiang and Landrace pigs. These results may provide a theoretical basis for further studies of the molecular mechanism underlying the excellent meat quality of the Bama Xiang pig.

show abstract

“…The metabolic rate of small species following endurance training should therefore be relatively Body mass (kg) Post-training relative capillary density Figure 6: Relationship between post-endurance-training capillary density, expressed relative to capillary density of untrained individuals, and body mass. Data are from published studies, including a range of training durations, methods, and intensities (Hermansen and Wachtlova 1971;Andersen and Henriksson 1977;Ingjer 1979;Adolfsson et al 1981;Klausen et al 1981;Hoppeler et al 1984Hoppeler et al , 1985Essén-Gustavsson et al 1989;Bigard et al 1991;Rivero et al 1995;McCall et al 1996;Serrano et al 2000;Amaral et al 2001;Waters et al 2004;Chinsomboon et al 2009;Geng et al 2010). …”

Section: Implications For Capillary Densities Cellular Metabolic Ratmentioning

confidence: 99%

Testing Metabolic Theories

Kearney

White

2012

The American Naturalist

View full text Add to dashboard Cite

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. abstract: Metabolism is the process by which individual organisms acquire energy and materials from their environment and use them for maintenance, differentiation, growth, and reproduction. There has been a recent push to build an individual-based metabolic underpinning into ecological theory-that is, a metabolic theory of ecology. However, the two main theories of individual metabolism that have been applied in ecology-Kooijman's dynamic energy budget (DEB) theory and the West, Brown, and Enquist (WBE) theoryhave fundamentally different assumptions. Surprisingly, the core assumptions of these two theories have not been rigorously compared from an empirical perspective. Before we can build an understanding of ecology on the basis of individual metabolism, we must resolve the differences between these theories and thus set the appropriate foundation. Here we compare the DEB and WBE theories in detail as applied to ontogenetic growth and metabolic scaling, from which we identify circumstances where their predictions diverge most strongly. Promising experimental areas include manipulative studies of tissue regeneration, body shape, body condition, temperature, and oxygen. Much empirical work designed specifically with DEB and WBE theory in mind is required before any consensus can be reached on the appropriate theoretical basis for a metabolic theory of ecology.

show abstract

PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle

Cited by 225 publications

References 54 publications

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Comparisons of different myosin heavy chain types, AMPK, and PGC-1α gene expression in the longissimus dorsi muscles in Bama Xiang and Landrace pigs

Testing Metabolic Theories

Contact Info

Product

Resources

About