PGC-1α-siRNA suppresses inflammation in substantia nigra of PD mice by inhibiting microglia

Guan, Xin Yuan; Wu, Pengyue; Cao, Bing; Liu, Xiaoting; Chen, Xi; Zhang, Wenpei; Zhang, Yanqiu; Guan, Zhenlong; Wang, Yanqin

doi:10.1080/00207454.2021.1910257

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…However, PGC-1α deficiency is opposite. 428,430,[456][457][458][459][460][461][462] However, there are discrepancies between different studies. Lasting overexpression of PGC-1α contributes to major alterations in the metabolic activity of neuronal cells, which dramatically impairs dopaminergic function, reduces striatal DA content, and enhances susceptibility to MPTP.…”

Section: Pgc-1s In Atherosclerosismentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, and inflammation. Accumulating evidence has shown that PGC-1s are implicated in many diseases, such as cancers, cardiac diseases and cardiovascular diseases, neurological disorders, kidney diseases, motor system diseases, and metabolic disorders. Examining the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of PGC-1s. Furthermore, discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention methods. In this review, we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network, discuss the physio-pathological roles of PGC-1s in human diseases, review the application of PGC-1s, including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies, and suggest several directions for future investigations. This review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

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Section: Pgc-1s In Atherosclerosismentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

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“…It has been reported that microglia are currently considered a source of MMPs in psychiatric disorders, thus being responsible for PNN manipulation (Crapser et al, 2020 ; Wegrzyn et al, 2021 ). PGC-1α downregulation suppresses inflammation in the substantia nigra of PD mice by inhibiting microglia activity (Guan et al, 2023 ). However, further studies are necessary to clarify whether the impact of PNN integrity and synaptic plasticity by PGC-1α is due to an alteration of microglia activity.…”

Section: Discussionmentioning

confidence: 99%

PGC-1α regulates critical period onset/closure, mediating cortical plasticity

Zhang,

Shi,

Guo

et al. 2023

Front. Mol. Neurosci.

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Peroxisome proliferator-activated receptor PPARγ coactivator-α (PGC-1α) is concentrated in inhibitory interneurons and plays a vital role in neuropsychiatric diseases. We previously reported some characteristic features of schizophrenia (SZ) in GABAergic neuron-specific Pgc-1alpha knockout (KO) mice (Dlx5/6-Cre: Pgc−1alphaf/f). However, there is a fundamental gap in the molecular mechanism by which the Pgc-1alpha gene is involved in the neurobehavioral abnormalities of SZ. The loss of critical period (CP) triggers–maturations of parvalbumin interneurons (PVIs) and brakes—and the formation of perineuronal nets (PNNs) implicates mistimed trajectories during adult brain development. In this study, using the Pgc-1alpha KO mouse line, we investigated the association of Pgc-1alpha gene deletion with SZ-like behavioral deficits, PVI maturation, PNN integrity and synaptic ultrastructure. These findings suggest that Pgc-1alpha gene deletion resulted in a failure of CP onset and closure, thereby prolonging cortical plasticity timing. To determine whether the manipulation of the PNN structure is a potential method of altering neuronal plasticity, GM6001, a broad-spectrum matrix metalloproteinase (MMP)-inhibitor was applied. Here we confirmed that the treatment could effectively correct the CP plasticity window and ameliorate the synaptic ultrastructure in the Pgc-1alpha KO brain. Moreover, the intervention effect on neuronal plasticity was followed by the rescue of short-term habituation deficits and the mitigation of aberrant salience, which are some characteristic features of SZ. Taken collectively, these findings suggest that the role of PGC-1α in regulating cortical plasticity is mediated, at least partially, through the regulation of CP onset/closure. Strategically introduced reinforcement of molecular brakes may be a novel preventive therapy for psychiatric disorders associated with PGC-1α dysregulation.

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“…The management by objectives (MBO)-oriented talent management proposed by Lai et al [ 18 ] mainly combines the evaluation process with the management process and has a good guiding role in the process of selecting key talent indicators that can achieve corporate goals and control the relevant key links of key talent indicators, so as to lead the enterprise forward under a correct and consistent guidance and, at the same time, stimulate the enthusiasm and creativity of employees, thus laying a solid foundation for the realization of the unity of operation and management within the enterprise. Guan et al [ 19 ] believe that MBO-oriented talent management consists of four closely related parts, namely, planning, guidance, evaluation, and incentives. These four stages are combined with the four stages of management by objectives, execution, evaluation, and feedback, respectively.…”

Section: Related Workmentioning

confidence: 99%

Construction and Application of Talent Evaluation Model Based on Nonlinear Hierarchical Optimization Neural Network

Pei

2022

Computational Intelligence and Neuroscience

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Talent assessment attracts the attention of researchers because of its important influence on business management issues. The traditional talent evaluation model has high sample selection cost and large calculation volume ratio, so it has become an urgent problem to be solved. Based on the nonlinear hierarchical optimization neural network, this article improves the corresponding talent evaluation index system and builds a talent evaluation model on the basis of demonstrating the feasibility of using a nonlinear hierarchical optimization neural network for talent evaluation. This article conducts an empirical analysis on the talent evaluation model of the talent evaluation team members and designs a prototype system of the talent evaluation index system based on the nonlinear hierarchical optimization neural network. In the simulation process, MATLAB software is used to complete the program realization of the model, and the accuracy and feasibility of the model are verified by combining the case. Through the evaluation and research of the implementation personnel of the case enterprise, the enterprise talent evaluation based on the nonlinear hierarchical optimization neural network is demonstrated. The empirical results show that it is feasible and accurate to use the nonlinear hierarchical optimization neural network to evaluate the talent evaluation team. The comprehensive prediction accuracy rate of T-1 year is 88.5%, and the comprehensive prediction accuracy rate of T-2 year was 83.45%, which effectively promoted the evaluation of enterprise talents.

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PGC-1α-siRNA suppresses inflammation in substantia nigra of PD mice by inhibiting microglia

Cited by 6 publications

References 33 publications

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

PGC-1α regulates critical period onset/closure, mediating cortical plasticity

Construction and Application of Talent Evaluation Model Based on Nonlinear Hierarchical Optimization Neural Network

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