PGC1α Controls Sucrose Taste Sensitization in Drosophila

Wang, Qiao‐Ping; Lin, Yong; Lai, Mei-Jung; Su, Zhiduan; Oyston, Lisa J.; Clark, Teleri; Park, Scarlet J.; Khuong, Thang M.; Lau, Man-Tat; Shenton, Victoria; Shi, Yan‐Chuan; James, David E.; Ja, William W.; Herzog, Herbert; Simpson, Stephen J.

doi:10.1016/j.celrep.2020.03.044

Cited by 28 publications

(23 citation statements)

References 65 publications

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“…We assume that such short-lasting effects in each flies' recurring hunger/feeding/satiety cycles are cancelled out by interindividual variance, since we do not observe any obvious correlation in activity on the binned level of start-synchronised 24 h data (not shown) that would point towards a coordinated habituation effect. Adaptation of taste-sensing neurons can occur over longer time frames, after permanent dietary intervention (May et al, 2019;Wang et al, 2020b). Exposure to high concentration sucrose might either differentially desensitise gustatory sensilla in pre-fed and prestarved flies, or the prolonged hunger experience in pre-starved flies leads to a permanent sensitisation of gustatory sensilla.…”

Section: Discussionmentioning

confidence: 99%

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Mahishi

Triphan

Hesse

et al. 2021

Front. Behav. Neurosci.

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how permanent contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup—the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: (i) in single patches and (ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches which seems to be not driven by immediate hunger motivation.

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Section: Discussionmentioning

confidence: 99%

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Mahishi

Triphan

Hesse

et al. 2021

Front. Behav. Neurosci.

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“…Hunger is known to sensitise certain chemosensory and other circuits at the expense of others, but such sensitisation is usually reversed as soon as the caloric demand is met (Root et al, 2011;Nishimura et al, 2012;Farhan et al, 2013;Inagaki et al, 2014;Longden et al, 2014;Sachse and Beshel, 2016;Grunwald Kadow, 2019;Lin et al, 2019;Wang and Wang, 2019). Habituation and sensitisation of tarsal sugar responses are only described in the minute range (Duerr and Quinn, 1982;Scheiner, 2004; Paranjpe et al, 2012), whereas adaptation of taste-sensing neurons can occur over longer time frames, after chronic dietary intervention (May et al, 2019;Wang et al, 2020b). Exposure to high concentration sucrose might either differentially desensitise gustatory sensilla in fed and pre-starved flies, or the prolonged hunger experience in pre-starved flies leads to a chronic sensitisation of gustatory sensilla.…”

Section: Discussionmentioning

confidence: 99%

Long-lasting impact of starvation experience on fly activity and place preference

Mahishi

Triphan

Hesse

et al. 2020

Preprint

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how chronic contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup – the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: i) in single patches, and ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches not driven by immediate hunger motivation.

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“…A followup study showed that sugar metabolites induce taste plasticity by remodeling the transcriptome of the sweet sensing neurons (Vaziri et al, 2020 ); specifically, the authors uncovered that the epigenetic silencer Polycomb Repressive Complex 2 (PRC2) suppressed a neurodevelopmental program required for neural plasticity by changing its binding to chromatin in a diet-dependent way (Vaziri et al, 2020 ). Of note, another group uncovered that dietary sweet taste plasticity also engaged a signaling pathway that activated the transcription factors cAMP-response element binding protein (CREB) and Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α; Wang et al, 2020 ).…”

Section: The Effect Of High Fat and High Sugar Diets On D Melanogaster Behaviorsmentioning

confidence: 99%

Crème de la Créature: Dietary Influences on Behavior in Animal Models

Sarangi

Dus

2021

Front. Behav. Neurosci.

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In humans, alterations in cognitive, motivated, and affective behaviors have been described with consumption of processed diets high in refined sugars and saturated fats and with high body mass index, but the causes, mechanisms, and consequences of these changes remain poorly understood. Animal models have provided an opportunity to answer these questions and illuminate the ways in which diet composition, especially high-levels of added sugar and saturated fats, contribute to brain physiology, plasticity, and behavior. Here we review findings from invertebrate (flies) and vertebrate models (rodents, zebrafish) that implicate these diets with changes in multiple behaviors, including eating, learning and memory, and motivation, and discuss limitations, open questions, and future opportunities.

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PGC1α Controls Sucrose Taste Sensitization in Drosophila

Abstract: Highlights d Diet manipulation can alter sucrose sensitivity d Sucrose sensitization requires dopamine signaling d Gas, PKA, CREB, and PGC1a mediate sensitization within sweet taste neurons d PGC1a is necessary and sufficient to drive taste sensitization

Cited by 28 publications

References 65 publications

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Long-lasting impact of starvation experience on fly activity and place preference

Crème de la Créature: Dietary Influences on Behavior in Animal Models

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