PGI4 Assessing the Use of a Harmonic Scalpel in Laparoscopic Cholecystectomy: A Systematic Review of the Evidence

Abstract

multiple liner regression analysis. RESULTS: The mean utility scores (SD) were 0.75(0.19) for EQ-5D and 0.68(0.12) for SF-6D. Validity was demonstrated by the moderate to strong correlation coefficients (range: 0.404-0.594, PϽ0.001) for four of the eight hypotheses in both EQ-5D and SF-6D. There were no serious ceiling effects for EQ-5D and SF-6D but floor effects for EQ-5D were large. SF-6D showed a better discriminative capacity (ESϭ0.573-1.179) between groups with different SAP-specific health status than EQ-5D (ESϭ0.385-0.851). RE showed that SF-6D (32.7-218.7%) was more efficient than EQ-5D. The areas under ROC of them all exceeded 0.5 (0.661-0.814, PϽ0.001). Poor agreement between them was observed with ICC (0.477, PϽ0.001) and Bland-Altman plot analysis. Multiple liner regression showed that clinical variables significantly (PϽ0.05) influenced differences in utility scores between EQ-5D and SF-6D. CONCLUSIONS: This study provides evidence that EQ-5D and SF-6D are valid and sensitive preference-based HRQoL instruments in Chinese SAP patients. SF-6D may be a more effective tool with lower flooring effect and greater sensitivity. Further study is needed to compare other properties, such as reliability and longitudinal response.