2020
DOI: 10.3389/fcimb.2020.00451
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PGRS Domain of Rv0297 of Mycobacterium tuberculosis Is Involved in Modulation of Macrophage Functions to Favor Bacterial Persistence

Abstract: Mycobacterium tuberculosis (M. tb) Rv0297-encoded PE_PGRS5 has been known to be expressed at the later stages of infection and in acidified phagosomes during transcriptome and proteomic studies. The possible role of Rv0297 in the modulation of phagosomal maturation and in providing protection against a microbicidal environment has been hypothesized. We show that Rv0297PGRS is involved in modulating the calcium homeostasis of macrophages followed by impedance of the phagolysosomal acidification process. This is… Show more

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Cited by 21 publications
(22 citation statements)
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References 69 publications
(118 reference statements)
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“…Recently, M. tuberculosis Rv0297PGRS domain was revealed to be a player in this game. The recombinant protein expressed in non-pathogenic mycobacteria induced low acquisition of cathepsin D and Rab7 in the human cell line THP1, by interference in the maturation of phagolysosomes ( 125 ).…”
Section: Cathepsins and Inhibitors In The Establishment Of Chronic Intracellular Niches And Immune Responsesmentioning
confidence: 99%
“…Recently, M. tuberculosis Rv0297PGRS domain was revealed to be a player in this game. The recombinant protein expressed in non-pathogenic mycobacteria induced low acquisition of cathepsin D and Rab7 in the human cell line THP1, by interference in the maturation of phagolysosomes ( 125 ).…”
Section: Cathepsins and Inhibitors In The Establishment Of Chronic Intracellular Niches And Immune Responsesmentioning
confidence: 99%
“…Mycobacteria can also prevent direct digestion by cathepsins in macrophages by escaping from the phagosome into the cytosol, resulting in activation of the inflammasome and subsequent stimulation of Cts B-dependent pyroptosis or pyronecrosis (Welin et al, 2011;Pires et al, 2016;Amaral et al, 2018). Recently, M. tuberculosis Rv0297 has been shown to down-regulate Cts D and Rab7 expression in macrophages, suggesting its role in modulation of phagosomal maturation (Sharma et al, 2020). Avoidance of cathepsindependent killing by mycobacteria allows them to effectively replicate and spread to neighboring cells.…”
Section: Mycobacterium Tuberculosismentioning
confidence: 99%
“…Multiple pieces of evidence show that M. tb too avoids autophagic degradation and may exploit this process for its advantage by utilizing various effector proteins (18,19). M. tb encodes a wide range of effector molecules that can trigger immune responses or manipulate signaling pathways within the host to promote its persistence (20). M. tb antigens, NuoG, ESAT-6, Hsp16.3, and Eis, have been already shown to downregulate the host autophagic process (21)(22)(23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%