Ph chromosome in a patient with non‐leukemic non‐hodgkin B‐cell lymphoma

Abstract

A standard Philadelphia translocation, t(9;22) (q34;q11), was found in lymph node cells from a patient with non-leukemic non-Hodgkin lymphoma at the time of diagnosis. The rearrangement of the breakpoint cluster region (bcr) was not detected with a bcr-3' probe. The neoplastic clone was of monoclonal B-cell character with E-, CD5-, CD10-, CD13-, CD19+, CD20+, CD21+, CD25-, HLA DR+, and positive surface Ig(kappa). The patient showed no evidence of chronic myelogenous leukemia.

Myeloid Antigen, CD13, CD14, and/or CD33 Expression Is Restricted to Certain Lymphoid Neoplasms

“…34 Similarly, all but one of our cases with mature B-cell malignancy examined lacked CD34, suggesting that the mechanism of MyAg expression in such disease may not be due to a multipotentiality of stem cell disorder like undifferentiated ALL. However, because some cases of t(9;22) positive non-leukemic B-NHL have been reported, 35 and we observed one case of CD34 positive PCL, even mature B-cell tumors may be heterogenous in cell origin. Also, CD 14 antigen on normal and malignant B-cells is known to be detectable by only My4 MoAb but not by other anti-CD 14 MoAb such as LeuM3 and Mo2.…”

Philadelphia-like translocation t(9;22)(q34;q11) found in a follicular lymphoma involving notBCR andABL butIGL-mediated rearrangement of an unknown gene on 9q34

“…In the latter cases, a new aberrant fusion protein, p-190 BCR-ABL is detected, in contrast to the CML-specific p-210 BCR-ABL. Occasionally, the t(9;22)(q34;q11) has also been reported in some multiple myeloma (Van den Berghe et al, 1979) and non-Hodgkin lymphoma (NHL) patients (Nordenson et al, 1983;Barbieri et al, 1984;Yunis et al, 1984;Juliusson et al, 1985;Palka et al, 1986;Maseki et al, 1987;Terjanian et al, 1989;Fujii et al, 1990;Mitani et al, 1990;Offit et al, 1991). In these cases, however, the translocation has not been well documented at the molecular level.…”

Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis: report of two cases and review of the literature

“…[47][48][49][50][51][52][53][54][55][56] All Ph(+) B cell lymphomas histologically showed a peripheral B cell type, that is, no 'blastic' features, three of which also showed negativity for CD10. [53][54][55] Most cases may be much more likely genetically Ph(+) lymphomas since their BCR/ABL rearrangements were demonstrated by conventional cytogenetics and BCL/ABL protein analysis, besides Southern blot analysis. However, it must be confirmed from the examination of our cases that it would be quite difficult to state whether the NHL truly carried the BCR/ABL gene translocation without FISH.…”