pH-Controllable drug release using hydrogel encapsulated mesoporous silica

Song, Shaotang; Hidajat, K.; Kawi, Sibudjing

doi:10.1039/b707626f

Cited by 131 publications

(83 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the development of new delivery systems is often considered as a commercially viable alternative to the expense of drug discovery and development [1][2][3]. Controlled drug delivery systems have now been developed to the point where they can facilitate site-specific delivery at precisely controlled rates [4][5][6][7][8][9]. Control over the delivery rate minimizes the toxicity and side effects of the drug being delivered [1,[10][11][12][13][14][15].…”

mentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

show abstract

mentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

show abstract

“…As the control, the loading experiment of MSNs-PAA was also carried out in the pH 1.2 PBS solutions, the LC (3.62 g/mg) and EE (4.34%) was far lower than that of in pH 8.0 PBS solutions. The pK a of PAA is 4.5 (Song et al, 2007), so the carboxylate groups of PAA on the surface of MSNs were deprotonated and then became soluble in relatively high pH 8.0 solutions, forming an opened state (Fig. 1).…”

Section: Ee and Lc Of Salidroside In Msns-paamentioning

confidence: 99%

“…PAA has good solubility at high pH values (pH ≥ 8), however it has poor solubility and even collapses entangled together to precipitate from solution at low pH values (pH ≤ 4.0) (Hong et al, 2009). PAA has other properties of forming a well-known bioadhesive hydrogel, sticking to the mucosal lining of the upper small intestine and protecting some protein drugs from degradation (Song et al, 2007). MSNs have been modified with PAA by layer-by-layer adsorption technique (Song et al, 2007) and "graft to" strategy of reversible addition-fragmentation chain transfer (RAFT) (Hong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…PAA has other properties of forming a well-known bioadhesive hydrogel, sticking to the mucosal lining of the upper small intestine and protecting some protein drugs from degradation (Song et al, 2007). MSNs have been modified with PAA by layer-by-layer adsorption technique (Song et al, 2007) and "graft to" strategy of reversible addition-fragmentation chain transfer (RAFT) (Hong et al, 2009). However, the above two modified techniques suffer from shortcomings of the irreversibility of the pore opening for layer-by-layer adsorption technique, and the relative tedious multiple-step syntheses for the "graft to" strategy (Fleming et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside

Peng

Dong

Wang

et al. 2013

International Journal of Pharmaceutics

117

View full text Add to dashboard Cite

“…Kawi and co-workers made polyacrylic acid coated MSNs to achieve the release of protein at physiological pH. 123 Hence, research based on MSN lacks conventional targets such as the colon, small intestine, and liver. It will be interesting to see the effect of these novel nanoparticles upon these human organs.…”

mentioning

confidence: 99%

Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

et al. 2011

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes to retain their activity, affording them greater potential for wide applications in biocatalysis and energy. This review provides a comprehensive summary of the advances made in the last decade and a future outlook on possible applications of MSNs as nanocontainers for storage and delivery of biomolecules. We discuss some of the important factors affecting the adsorption and release of biomolecules in MSNs and review of the cytotoxicity aspects of such nanomaterials. The review also highlights some promising work on enzyme immobilisation using mesoporous silica nanoparticles.

show abstract

pH-Controllable drug release using hydrogel encapsulated mesoporous silica

Cited by 131 publications

References 19 publications

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside

Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

Contact Info

Product

Resources

About