pH-controlled delivery of gentamicin sulfate from orthopedic devices preventing nosocomial infections

Pichavant, Loïc; Amador, Gilles; Jacqueline, Cédric; Brouillaud, Brigitte; Héroguez, Valérie; Durrieu, Marie‐Christine

doi:10.1016/j.jconrel.2012.06.033

Cited by 69 publications

(63 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32,33 Besides, the delivery method of localized drugs or growth factors is found to be an efficient method to overcome graft associated problems including healing deficits and bacterial infection. 34,35 In the present study, the surface modification technique was used to coat the biological active factor on the surface of UHMWPE fibers. Chromic acid treatment was applied to introduce functional groups to the surface of fibers and etch the amorphous regions of fibers.…”

Section: Discussionmentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

View full text Add to dashboard Cite

Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM) and attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8) assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT) analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF coating. This study showed that the method loading VEGF on UHMWPE by SF coating played an effective role on the biological performance of UHMWPE and displayed a great potential application for anterior cruciate ligament reconstruction.

show abstract

Section: Discussionmentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…The poor circulation of blood in the osseous tissue makes necessary the supply of great amount of antibiotics to reach the adequate therapeutic level in the affected region. These systems allow the release by diffusion of an antibiotic through a biodegradable polymer matrix [18][19][20][21]. Some studies showed that different stimuli as temperature or pH [18] involve the release of the drug [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Wers

Oudadesse

Lefeuvre

et al. 2015

Applied Surface Science

View full text Add to dashboard Cite

International audienceChitosan scaffolds, combined with bioactive glass 46S6, were prepared to serve as gentamicin sulfate delivery in situ systems for bone biomaterials. This work presents a study about the effect of the ratio chitosan/bioactive glass (CH/BG) on the release of gentamicin sulfate and on the bioactivity during in vitro experiments. SEM observations allowed understanding the bond between the glass grains and the chitosan matrix. In vitro results showed that scaffolds form a hydroxyapatite (HA) Ca10(PO4)6(OH)2 after 15 days of immersion in a simulated body fluid (SBF).The interest of this study is to see that the increase of the content of bioactive glass in the chitosan matrix slows the release of gentamicin sulfate in the liquid medium. Starting concentration of gentamicin sulfate has an influence on the relaxation time of the scaffolds. Indeed, an increasing concentration delays the return to a new equilibrium. Contents of chitosan and bioactive glass do not affect the relaxation time. Synthesized scaffolds could be adapted to a clinical situation: severity and type of infection, weight and age of the patient

show abstract

“…Self-regulating CR systems can be developed to release their payload in the presence of biomarkers of pain, inflammation or infection [72,77,78]. Achieving an appropriate balance of inflammation is critical to the healing process.…”

Section: Cutting Edge Technologiesmentioning

confidence: 99%

“…Recently, a pH-responsive CR device loaded with gentamicin was reported for use following orthopaedic surgery [78]. Functionalized nanoparticle incorporating gentamycin sulphate was bonded to titanium surface of biomaterial.…”

Section: Cutting Edge Technologiesmentioning

confidence: 99%

“…Infection is associated with a fall in pH resulting in release of antibiotic. Reprinted with permission from Elsevier [78] Conclusion This review has summarized the needs of post-operative pharmacotherapy and the benefits and limitations of the currently adopted CR systems. CR systems can release drugs where they are required, at an appropriate concentration for an extended period of time with the demonstrated ability to be translated from laboratory bench to patient bedside to improve treatment efficacy and adherence.…”

Section: Challenges and Promises Of Translating Technologies Into Posmentioning

confidence: 99%

See 1 more Smart Citation

Controlled release drug delivery systems to improve post-operative pharmacotherapy

Bhusal

Harrison

Sharma

et al. 2016

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Over 230 million surgical procedures are conducted worldwide each year with numbers increasing. Pain, undesirable inflammation and infection are common complications experienced by patients following surgery. Opioids, non-steroidal anti-inflammatory drugs (NSAIDs), local anaesthetics (LAs) and antibiotics are the commonly administered drugs peri-operatively to manage these complications. Post-operative pharmacotherapy is typically achieved using immediate-release dosage forms of drugs, which lead to issues around fluctuating plasma concentrations, systemic adverse effects and poor patient adherence. Controlled release (CR) systems for certain medicines including opioids, NSAIDs and antibiotics have demonstrably enhanced treatment efficacy in the post-surgical setting. However, challenges remain to ensure patient safety while achieving individual therapeutic needs. Newer CR systems in the research and development pipeline have a high level of control over medicine release, which can be initiated, tuned or stopped on-demand. Future systems will self-regulate drug release in response to biological markers providing precise individualized therapy. In this review, we cover currently adopted CR systems in post-operative pharmacotherapy, including drug eluting medical devices, and highlight a series of examples of novel CR technologies that have the potential for translation into post-surgical settings to improve medication efficacy and enhance post-surgical recovery.

show abstract

pH-controlled delivery of gentamicin sulfate from orthopedic devices preventing nosocomial infections

Cited by 69 publications

References 59 publications

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Controlled release drug delivery systems to improve post-operative pharmacotherapy

Contact Info

Product

Resources

About