pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging

Kalay, Şaban; Stetsyshyn, Yurij; Donchak, Volodymyr; Harhay, Khrystyna; Lishchynskyi, Ostap; Ohar, Halyna; Panchenko, Yuriy; Voronov, Stanislav; Çulha, Mustafa

doi:10.3762/bjnano.10.233

Cited by 15 publications

(13 citation statements)

References 61 publications

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“…For this, PNs prepared using PMAA as a polymeric matrix can perform as a pH-sensitive nano-carrier in aqueous medium. This fact improves the potential interest in prepared PNs because the use of water-dispersed pH-sensitive sensors are of current interest, as was reported elsewhere [ 11 ].…”

Section: Introductionsupporting

confidence: 57%

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

et al. 2022

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The design of nanocomposites with the potential for drug delivery is a topic of great interest. In this work, the synthesis of nanocomposites of poly(methacrylic acid) (PMAA) grafted onto carbon nanotubes (CNTs) functionalized with poly(amidoamine) (PAMAM) dendrimer by semicontinuous heterophase polymerization SHP, at three different methacrylic acid (MAA) dosing rates, is reported. SHP is a polymerization technique poorly used to prepare nanocomposites containing CNTs and has the potential to produce more ordered alkyl methacrylic polymer chains, which could favor the obtaining of a homogenous nanocomposite. For the nanocomposites synthesized, a lowest addition rate monomer-starved condition was reached. Analysis by X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA) demonstrate that functionalized CNTs are grafted onto the PMAA matrix. The ability of prepared nanocomposites to deliver hydrocortisone was evaluated by ultraviolet-visible spectroscopy (UV-Vis). The hydrocortisone release profiles of pure PMAA and of their nanocomposites prepared at the lowest monomer fed rate were fitted with Higuchi and Korsmeyer–Peppas models, successfully. Functionalized CNTs have a crucial role to induce an effective release of hydrocortisone from the prepared nanocomposites.

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Section: Introductionsupporting

confidence: 57%

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

et al. 2022

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“…[117][118] Fluorescein-based polymers are pH-sensitive polymers that exhibit fluorescence in response to changes in pH. pHswitchable, fluorescent, hybrid, water-dispersible nanomaterials based on boron nitride nanotubes and grafted poly(acrylic acid-co-fluorescein acrylate) copolymer brushes were successfully manufactured in work [119] (Figs. 11a and b).…”

Section: Polymer Systems With Ph-induced Isomerization (Ring Opening/...mentioning

confidence: 99%

“…Figure 11. Structure of hybrid nanomaterials based on boron nitride nanotubes and grafted poly(acrylic acid-co-fluorescein acrylate) copolymer brushes.Reproduced from ref [119]…”

mentioning

confidence: 99%

Switching it Up: The Promise of Stimuli‐Responsive Polymer Systems in Biomedical Science

Shymborska,

Budkowski,

Raczkowska

et al. 2023

The Chemical Record

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Responsive polymer systems have the ability to change properties or behavior in response to external stimuli. The properties of responsive polymer systems can be fine‐tuned by adjusting the stimuli, enabling tailored responses for specific applications. These systems have applications in drug delivery, biosensors, tissue engineering, and more, as their ability to adapt and respond to dynamic environments leads to improved performance. However, challenges such as synthesis complexity, sensitivity limitations, and manufacturing issues need to be addressed for successful implementation. In our review, we provide a comprehensive summary on stimuli‐responsive polymer systems, delving into the intricacies of their mechanisms and actions. Future developments should focus on precision medicine, multifunctionality, reversibility, bioinspired designs, and integration with advanced technologies, driving the dynamic growth of sensitive polymer systems in biomedical applications.

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“…There is a drawback concerning this type of reinforced polymeric material. Sometimes, there is no good compatibility between the polymer and the reinforcement, thus reducing the material properties to be obtained [ 108 , 109 , 110 ]. The use of additives to improve material properties for processing and application is common practice in sheet molding compounds for traditional injection molding applications [ 111 , 112 ].…”

Section: Advances In the Design Of Novel Materials For Ammentioning

confidence: 99%

Innovation in Additive Manufacturing Using Polymers: A Survey on the Technological and Material Developments

et al. 2022

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This review summarizes the most recent advances from technological and physico-chemical perspectives to improve several remaining issues in polymeric materials’ additive manufacturing (AM). Without a doubt, AM is experimenting with significant progress due to technological innovations that are currently advancing. In this context, the state-of-the-art considers both research areas as working separately and contributing to developing the different AM technologies. First, AM techniques’ advantages and current limitations are analyzed and discussed. A detailed overview of the efforts made to improve the two most extensively employed techniques, i.e., material extrusion and VAT-photopolymerization, is presented. Aspects such as the part size, the possibility of producing parts in a continuous process, the improvement of the fabrication time, the reduction of the use of supports, and the fabrication of components using more than one material are analyzed. The last part of this review complements these technological advances with a general overview of the innovations made from a material perspective. The use of reinforced polymers, the preparation of adapted high-temperature materials, or even the fabrication of metallic and ceramic parts using polymers as supports are considered. Finally, the use of smart materials that enable the fabrication of shape-changing 3D objects and sustainable materials will also be explored.

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pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging

Cited by 15 publications

References 61 publications

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

Switching it Up: The Promise of Stimuli‐Responsive Polymer Systems in Biomedical Science

Innovation in Additive Manufacturing Using Polymers: A Survey on the Technological and Material Developments

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