pH-Dependent release system of isoniazid carried on nanoparticles of silica obtained from expanded perlite

Almeida, Janiele Mayara Ferreira de; Júnior, Elmar Damasceno; Verríssimo, Lourena Mafra; Fernandes, Nedja Suely

doi:10.1016/j.apsusc.2019.05.317

Cited by 20 publications

(20 citation statements)

References 59 publications

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“…Similar results were obtained in our previous work, in which we evaluated the adsorption of isoniazid in the palygorskite . According to de Almeida et al (2019), increasing the concentration of the drug in the medium can guarantee an increase in the number of molecules that are available to be adsorbed on the nanocarrier surfaces. At low concentrations, the relationship between the number of drug molecules per specific area of the adsorbent is minimal.…”

Section: Resultssupporting

confidence: 85%

“…Although the data presented in Table infer that the incorporation efficiency is higher using 600 mg of palygorskite, larger amounts of RIF were adsorbed per gram of PAL in the experiments that used 300 mg of the clay mineral. Such a result shows that it is possible to obtain good doses for oral administration of the drug using smaller amounts of carrier, making the proposed system advantageous, both from an economic point of view and from the point of view of pharmacokinetics . Similar works that used the palygorskite as an adsorbent in the adsorption process of several molecules, such as the antibiotics metronidazole and spiramycin, the tuberculostatic isoniazid and the methylene blue dye, also showed similar results.…”

Section: Resultssupporting

confidence: 53%

“…In addition, it is known that the palygorskite has a negatively charged surface over a wide pH range (2–12) because of isomorphic substitutions in its structure. This clay therefore has a greater affinity for cationic molecules. ,− , As previously demonstrated, a considerable part of the molecules is found in their cationic form, reaching totality in the case of RIF, thus favoring the interaction of the basic groups of the molecule with the nanocarrier . This explains the higher incorporated dose values obtained at a more acidic pH.…”

Section: Resultsmentioning

confidence: 72%

“…The in vitro release studies were conducted according to the methodology used in a previous study . This methodology was based on the work of Oliveira, Alcântara, and Pergher (2017) and de Almeida et al (2019) . In order to simulate the in vivo transit of a pharmaceutical form for oral use in the gastrointestinal tract, three different dissolution media were used: pH 1.2 (simulating the stomach area) for 2 h, pH 6.8 (simulating the first intestinal zone) for 2 h, and pH 7.4 (simulating the second intestinal zone) for 4 h. Each medium was prepared by dissolving specific substances in 1000 mL ultrapure water (Milli-Q).…”

Section: Materials and Methodsmentioning

confidence: 99%

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Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

et al. 2020

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Despite having good efficacy in the treatment and prevention of tuberculosis, the administration of rifampicin (RIF) can cause serious side effects, resulting from the prolonged use of this substance. Thus, it is necessary to seek new systems for administering tuberculostatic drugs, to avoid unwanted adverse effects, increase their bioavailability and, consequently, improve their therapeutic efficacy. The present work describes the achievement of a pH-responsive system for RIF, using palygorskite, a fibrous clay mineral, as a nanocarrier. To evaluate the influence of some operational variables on the drug adsorption process, a 2 4 factorial experimental design was used. The experiment using a maximum concentration (0.125 mg/mL), lower mass of PAL (300 mg), and lower pH (pH 2) was more efficient compared to other experiments, resulting in a higher dose of the incorporated drug, equivalent to 33.62 mg/g. To elucidate the mechanism of interaction between the materials, the hybrid obtained was characterized by different characterization techniques (Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry/derived thermogravimetry, zeta potential, scanning electron microscopy, and dispersive energy spectroscopy). In addition, kinetic models and adsorption isotherms were applied to the experimental data. Through in vitro release studies, it was possible to verify the effectiveness of the pH-dependent system obtained. The adjustment of experimental release data to the theoretical model of Higuchi indicated that the release of rifampicin occurs in a prolonged way from the palygorskite.

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Section: Resultssupporting

confidence: 85%

Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 72%

Section: Materials and Methodsmentioning

confidence: 99%

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Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

et al. 2020

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“…These characteristics include a small size (between 1-100 nm), a large superficial area, high reactivity, and the extraordinary quantum effect [1,2]. Due to their physical-chemical characteristics, NPs have incredible pharmacokinetic properties and can be used as carriers of drugs or molecules for a specific purpose (antibiotics, antibodies, or organic molecules) [3,4]. However, nanoparticle stability remains challenging, due to the electrostatic attraction in naked NPs, which tend to agglomerate.…”

Section: Introductionmentioning

confidence: 99%

Palladium Nanoparticles Functionalized with PVP-Quercetin Inhibits Cell Proliferation and Activates Apoptosis in Colorectal Cancer Cells

et al. 2021

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Nanotechnology is focused on the development and application of novel nanomaterials with particular physicochemical properties. Palladium nanoparticles (PdNPs) have been used as antimicrobials, antifungals, and photochemicals and for catalytic activity in dye reduction. In the present investigation, we developed and characterized PdNPs as a carrier of quercetin and initiated a study of its effects in colorectal cancer cells. PdNPs were first functionalized with polyvinylpyrrolidone (PVP) and then coupled to quercetin (PdNPs-PVP-Q). Our results showed that quercetin was efficiently incorporated to PdNPs-PVP, as demonstrated using UV/Vis and FT-IR spectroscopy. Using transmission electron microscopy, we demonstrated a reduction in size from 3–14.47 nm of PdNPs alone to 1.8–7.4 nm of PdNPs-PVP and to 2.12–3.14 of PdNPs-PVP-Q, indicating an increase in superficial area in functionalized PdNPs-Q. Moreover, hydrodynamic size studies using dynamic light scattering showed a reduction in size from 2120.33 nm ± 112.53 with PdNPs alone to 129.96 nm ± 6.23 for PdNPs-PVP-Q, suggesting a major reactivity when quercetin is coupled to nanoparticles. X-ray diffraction assays show that the addition of PVP or quercetin to PdNPs does not influence the crystallinity state. Catalytic activity assays of PdNPs-PVP-Q evidenced the chemical reduction of 4-nitrophenol, methyl orange, and methyl blue, thus confirming an electron acceptor capacity of nanoparticles. Finally, biological activity studies using MTT assays showed a significant inhibition (p < 0.05) of cell proliferation of HCT-15 colorectal cancer cells exposed to PdNPs-PVP-Q in comparison to untreated cells. Moreover, treatment with PdNPs-PVP-Q resulted in the apoptosis activation of HCT-15 cells. In conclusion, here we show for the first time the development of PdNPs-PVP-Q and evidence its biological activities through the inhibition of cell proliferation and apoptosis activation in colorectal cancer cells in vitro.

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Remarkably Boosted Molecular Delivery Triggered by Combined Thermal and Flexoelectrical Field Dual Stimuli

Zhang

et al. 2020

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Efficient controllable drug delivery is important in medical treatment. Abrupt release of a drug is important in targeted drug release therapies or first-aid scenarios but materials reported to date still suffer from low efficiencies with regards to both release speeds and the total released amount. In this study, we report that combining both thermal and flexoelectrical field stimuli can lead to effective acceleration of drug delivery. When tapping the flexible substrate elevated temper-atures, acceleration of drug release is increased from up to 21 % to 540 % times for different molecules, remarkably higher than a single type of thermal or E-field stimulus. In addition, the dual responsive substrate exhibits good antibacterial effects. We believe that the work reported herein will be of benefit to the design of rapid drug release materials for medical treatment.

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pH-Dependent release system of isoniazid carried on nanoparticles of silica obtained from expanded perlite

Cited by 20 publications

References 59 publications

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

Palladium Nanoparticles Functionalized with PVP-Quercetin Inhibits Cell Proliferation and Activates Apoptosis in Colorectal Cancer Cells

Remarkably Boosted Molecular Delivery Triggered by Combined Thermal and Flexoelectrical Field Dual Stimuli

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