pH‐driven entrapment of enrofloxacin in casein‐based nanoparticles for the enhancement of oral bioavailability

Yuan, Zhixiang; Deng, Shichen; Chen, Li; Hu, You; Jian, Gu; He, Lili

doi:10.1002/fsn3.2224

Cited by 11 publications

(1 citation statement)

References 27 publications

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“…A casein-based delivery system for enrofloxacin for oral administration in rats significantly increased the average plasma concentration of enrofloxacin and The mean retention time increased from 9.287±0.524 to 11.372±1.139 h and the AUC increased 3.8 times to 20.850±1.7 ìg h mL -1 . Therefore, casein significantly enhanced the absorption of enrofloxacin and increased its half-life (Yuan et al, 2021). Another example is the use of a self-emulsifying solvent evaporation method to prepare enrofloxacin polymer micelles using the plastic filament material poly-lactic acid (PLA 16000) combined with the monomethyl ether form of polyethylene glycol (mPEG 2000) as carriers.…”

Section: Progress In the Development Of Enrofloxacin Sustained-and Co...mentioning

confidence: 99%

Research Progress in the Preparation of Enrofloxacin for Use in Veterinary Medicine

Wu¹,

Zhang²,

Liu³

et al. 2023

IJAR

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Background: Enrofloxacin is a special antibacterial agent for animals and is a synthetic third-generation fluoroquinolone broad-spectrum antibacterial agent. It has excellent antibacterial effects and is widely used in clinical practice. However, the solubility of enrofloxacin is extremely low and this has greatly limited its clinical use. We assessed progress in overcoming this deficiency by tracking pharmaceutical alterations to enrofloxacin in vivo delivery systems. Methods: We used the keywords ‘enrofloxacin’, ‘pharmaceuticals’ and ‘preparations’ to assess relevant literature sources collected in CNKI, Wanfang, Vepsa, China Patent Information Network, PubMed, Web of Science and other domestic and foreign databases from 2010 to 2022 to summarize the research progress of enrofloxacin pharmaceutics. Result: A total of 62 valid literature were retrieved and we found that pharmaceutic technologies successfully were able to increase enrofloxacin solubility, palatability, bioavailability and half-life. The continuous development and promotion of new drug formulations and new materials will give enrofloxacin preparations broad application prospects in veterinary medicine.

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Section: Progress In the Development Of Enrofloxacin Sustained-and Co...mentioning

confidence: 99%

Research Progress in the Preparation of Enrofloxacin for Use in Veterinary Medicine

Wu¹,

Zhang²,

Liu³

et al. 2023

IJAR

View full text Add to dashboard Cite

show abstract

Use of casein for pharmaceutical applications

Pilicheva,

Zahariev,

Milenkova

et al. 2024

Casein

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Opportunities for milk and milk-related systems as ‘new’ low-cost excipient drug delivery materials

Salim

Eason

Boyd

2022

Advanced Drug Delivery Reviews

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pH‐driven entrapment of enrofloxacin in casein‐based nanoparticles for the enhancement of oral bioavailability

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 27 publications

Research Progress in the Preparation of Enrofloxacin for Use in Veterinary Medicine

Research Progress in the Preparation of Enrofloxacin for Use in Veterinary Medicine

Use of casein for pharmaceutical applications

Opportunities for milk and milk-related systems as ‘new’ low-cost excipient drug delivery materials

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