pH homeostasis during cardiopulmonary resuscitation in critically ill patients

Survival in extremely acidotic cardiac arrest patients depends on etiology of acidosis

“…1 One prospective study on CA patients following respiratory failure showed that pH during CPR is affected by the pH prior to the arrest, the duration of arrest as well as quality of ventilation and circulation. 2 As long as CPR continues it generates a low cardiac output, causing tissue hypoperfusion and decreasing base excess. 3 A retrospective study on out-of-hospital-cardiac arrest found that base excess after ROSC correlated with CPR duration.…”

Prevalence of Sodium Bicarbonate–Induced Alkalemia in Cardiopulmonary Arrest Patients

“…9,10 Research reported positive resuscitation outcomes when SB was administered. 11 After vigorous study of acid-base balance in CPAs, the 1980 cardiopulmonary resuscitation (CPR) and emergency cardiac care guidelines decreased the recommended empiric dose of SB to 50 mEq. 9, 12 The 1980 guidelines stated: "It has become evident that less sodium bicarbonate is needed than had previously been assumed as necessary to provide adequate acid base control during arrest."…”