pH-Induced reversible self-assembly of gold nanoparticles functionalized with self-complementary zwitterionic peptides for near-infrared photothermal antibacterial treatment

Qin, Hao; Yang, Zhuoran; lv, Niannian; Ma, T.; Du, Kehan; Xiong, Jingyi; Jiang, Hao; Zhu, Jintao

doi:10.1039/d3nj00145h

Cited by 8 publications

(1 citation statement)

References 38 publications

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“…The minimum bactericidal/fungicidal concentration (MBC/MFC) of peptides against different microbes was determined by plate counting. [ 43 ] MBC/MFC was defined as the lowest concentration that would kill 99.9% of the test microorganisms in the medium. Based on the MIC values, a range of peptide solutions at concentrations between MIC and 2 MIC were selected for counting colonies after coincubation with the microbial solution.…”

Section: Methodsmentioning

confidence: 99%

Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections

Du,

Yang,

Qin

et al. 2023

Macromolecular Bioscience

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Antimicrobial peptides (AMPs) potentially serve as ideal antimicrobial agents for the treatment of polymicrobial abdominal infections due to their broad‐spectrum antimicrobial activity and excellent biocompatibility. However, the balance of chain length, positive charges, and hydrophobicity on the antimicrobial activity of AMPs are still far from being optimal. Herein, a series of AMPs ([KX]n‐NH2, X = Ile, Leu or Phe, n = 3, 4, 5, or 6) with varied charges and hydrophobicity for the treatment of polymicrobial abdominal infections are designed. Specifically, [KI]4‐NH2peptide exhibits the best in vitro antimicrobial activity against Gram‐positive and ‐negative bacteria, as well as fungal strains. Based on the good cell biocompatibility, [KI]4‐NH2peptide is found to have negligible in vivo toxicity at the dosage of up to 28 mg kg−1. Furthermore, great in vivo therapeutic efficacy of [KI]4‐NH2peptide againstS. typhimuriumis demonstrated in the mice abdominal infection model. The design of short sequence of antimicrobial peptides with a charge/hydrophobicity balanced structures provides a simple and efficient strategy for potential clinical applications of antimicrobial peptide‐based biomaterials in a variety of bacterial infection diseases.

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Section: Methodsmentioning

confidence: 99%

Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections

Du,

Yang,

Qin

et al. 2023

Macromolecular Bioscience

Self Cite

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Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

Xu,

He,

et al. 2024

Macromol. Rapid Commun.

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Amphiphilic peptides have garnered significant attention due to their highly designable and self‐assembling behaviors. Self‐assembled peptides hold excellent potential in various fields such as biosensing, environmental monitoring, and drug delivery, owing to their remarkable biological, physical, and chemical properties. While nanomaterials formed by peptide self‐assembly have found widespread use in biomedical applications, the development of 2D peptide nanosheets based on the self‐assembly of amphiphilic peptides remains challenging in terms of rational design and morphology modulation. In this study, rationally designed amphiphilic peptide molecules are self‐assembled into peptide nanosheets (PNS) under specific conditions to encapsulate gold nanoparticles (AuNPs), resulting in the formation of AuNPs/PNS hybrid materials with high photothermal conversion efficiency. The findings demonstrate that 2D PNS enhances the overall photothermal therapy effect of the nanohybrid materials due to their larger hosting area for AuNPs and higher biocompatibility. The well‐designed amphiphilic peptides in this study offer insights into the structural design and functional modulation of self‐assembled molecules. In addition, the constructed biomimetic‐functional 2D inorganic/organic nanohybrid materials hold potential applications in biomedical engineering.

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The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles

Hu,

Wang,

Huang

et al. 2024

Coordination Chemistry Reviews

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pH-Induced reversible self-assembly of gold nanoparticles functionalized with self-complementary zwitterionic peptides for near-infrared photothermal antibacterial treatment

Abstract: Aggregated gold nanoparticles (AuNPs) in response to the acidic microenvironment of bacterial infection sites upon near-infrared (NIR) light irradiation provides a facile approach against bacterial infection. Generally, the aggregation of...

Cited by 8 publications

References 38 publications

Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections

Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections

Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles

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