pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

Khimani, Mehul; Verma, Gunjan; Kumar, Sugam; Hassan, P. A.; Aswal, Vinod K.; Bahadur, Pratap

doi:10.1016/j.colsurfa.2015.01.051

Cited by 13 publications

(5 citation statements)

References 60 publications

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“…It is observed from SANS studies that in the absence of antioxidants 5% T1304 shows a distinctive scattering profile suggesting spherical micelles with a measured hard sphere radius ( R hs ) of ca 69.9 Å and N agg ca 36, which perfectly matches with the literature . The SANS pattern for 5% T1304 with 30 mmol L −1 antioxidants also shows a spherical shape with a slope of Q −4 (Fig.…”

Section: Resultssupporting

confidence: 83%

Solubilization, micellar transition and biocidal assay of loaded antioxidants in Tetronic® 1304 micelles

Patel

Ray

Pal

et al. 2020

Polymer International

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The current study scrutinizes the solubilization behaviour of pharmaceutically active antioxidants, namely hydrocinnamic acid (HCA), cinnamic acid (CA) and phenyl propiolic acid (PPA), in the micelles of polyethylene oxide-polypropylene oxide (PEO-PPO) based star-block copolymer: Tetronic® 1304 (T1304). A correlation between the molecular orbital energy levels of PEO-PPO units of T1304 and the active parts of the antioxidants are well explained using a simulation study. The antioxidants modulate core-shell micelles of T1304 with enhanced solubilization dependent on their unsaturation and hydrophobicity, as depicted from UV-visible spectroscopy. Antioxidants as an additive induce micellization in 5% w/v T1304 thereby modulating the phase behaviour, as indicated by the decrease in the cloud point. The cloud point results are well complemented by steady state fluorescence spectroscopy findings, depicting a decrease in critical micelle temperature due to the solubilization of antioxidants into the T1304 micelles. A significant difference between the hydrodynamic diameter (D h) of unloaded and loaded polymer micelles with antioxidants is observed from dynamic light scattering, ensuring the solubilization of the antioxidants in T1304 micelles. These results can apparently be attributed to the interaction and the charge induced by the antioxidants on non-ionic T1304 micelles which increase the micellar size. Furthermore, the role of unsaturation and hydrophobicity of the employed antioxidants in 5% T1304 demonstrates the solution viscosity (η) change as a function of temperature. In addition, small-angle neutron scattering depicts the shape transition (spherical to ellipsoidal to polymersomes) with temperature. The antioxidant loaded 5% T1304 micellar systems exhibit brilliant biocidal activity against the tested microbes, suggesting their antimicrobial application.

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Section: Resultssupporting

confidence: 83%

Solubilization, micellar transition and biocidal assay of loaded antioxidants in Tetronic® 1304 micelles

Patel

Ray

Pal

et al. 2020

Polymer International

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“…However, on the basis of partitioning, F127 micelles can efficiently solubilize SAL, retain it in the stomach and release it in the intestine, triggered by a change at physiological pH without DIMEB involvement. This effect has also been observed in P104 loaded with drugs with acid-basic properties [93], and it would be expected for SAL in P85 [27]. In comparison however, Pluronic F127 shows a higher solubilization ability ( >19 molecules/micelle, estimated from solubility data) than P85 (8 molecules/micelle) [27].…”

supporting

confidence: 58%

“…Most of the studies carried out with F127, drugs and DIMEB were conducted at pH=7, but very few have been reported at acidic pH [16]. Following oral administration, drugs go through a range of pH in the gastrointestinal tract, ranging from 1 to 9, however very few studies have explored the behaviour of free F127 micelles at this pH [25], or other Pluronics [26][27][28]. The solubility of ionizable drugs varies considerably at this pH and compromise drug bioavailability [29].…”

Section: Introductionmentioning

confidence: 99%

Solubilisation of salicylate in F127 micelles: Effect of pH and temperature on morphology and interactions with cyclodextrin

Valero

Houston

et al. 2021

Journal of Molecular Liquids

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“…As soon as the sample temperature increases, the whiteness increases up to about 70 • C, when a separation phase is detected. This transition may be due the onset of the cloud point temperature (CPT) [70,74]. At higher concentrations, i.e., sample of 20 wt.% it exhibits a similar trend to the more diluted sample (see Figure S1b in Supplementary Materials), but some differences were detected; about 60 • C where the MGT appears the sample exhibits a gel-like behavior.…”

Section: Visual Observationsmentioning

confidence: 91%

“…Small-angle neutron scattering (SANS) measurements have been used to study structural changes in a series of Pluronics, including P104, a moderately hydrophilic ethylene oxide-propylene oxide triblock, upon addition of increasing amounts of the drug ibuprofen, showing that the addition of ibuprofen to P104 reduces the CMT from approximately 20 • C to below 13 • C [19]. Scattering and rheology studies on micellar characteristics of P104 in the presence of anthranilic acid (AA) revealed important variations by changing the pH solution [70]. Furthermore, P104 has also been used in the study of dynamics between Pluronic micelles and liposomes for the vectorization of hydrophobic molecules using a fluorescence technique [11].…”

Section: Introductionmentioning

confidence: 99%

Structural Behavior of Amphiphilic Triblock Copolymer P104/Water System

Figueroa-Ochoa,

Bravo-Anaya,

Vaca-López

et al. 2023

Polymers

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A detailed study of the different structural transitions of the triblock copolymer PEO27–PPO61–PEO27 (P104) in water, in the dilute and semi-dilute regions, is addressed here as a function of temperature and P104 concentration (CP104) by mean of complimentary methods: viscosimetry, densimetry, dynamic light scattering, turbidimetry, polarized microscopy, and rheometry. The hydration profile was calculated through density and sound velocity measurements. It was possible to identify the regions where monomers exist, spherical micelle formation, elongated cylindrical micelles formation, clouding points, and liquid crystalline behavior. We report a partial phase diagram including information for P104 concentrations from 1 × 10−4 to 90 wt.% and temperatures from 20 to 75 °C that will be helpful for further interaction studies with hydrophobic molecules or active principles for drug delivery.

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pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

Cited by 13 publications

References 60 publications

Solubilization, micellar transition and biocidal assay of loaded antioxidants in Tetronic® 1304 micelles

Solubilization, micellar transition and biocidal assay of loaded antioxidants in Tetronic® 1304 micelles

Solubilisation of salicylate in F127 micelles: Effect of pH and temperature on morphology and interactions with cyclodextrin

Structural Behavior of Amphiphilic Triblock Copolymer P104/Water System

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