pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer’s disease

Rani, Varsha; Verma, Rinki; Kumar, Krishan; Chawla, Ruchi

doi:10.1007/s12038-023-00343-5

J Biosci

2023

DOI: 10.1007/s12038-023-00343-5

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pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer’s disease

Varsha Rani,

Rinki Verma,

Krishan Kumar

et al.

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Cited by 3 publications

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Synthesis, characterization, and biological evaluation of novel cinnamic acid derivatives: cinnamoyl-metronidazole ester and cinnamoyl-memantine amide

Shollar,

Merza,

Darwish

et al. 2024

Heliyon

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Synthesis, characterization, and biological evaluation of novel cinnamic acid derivatives: cinnamoyl-metronidazole ester and cinnamoyl-memantine amide

Shollar,

Merza,

Darwish

et al. 2024

Heliyon

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Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy

Zuo,

Sun,

Del Piccolo

et al. 2024

Nano Convergence

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Nanomedicine has been extensively explored for therapeutic and diagnostic applications in recent years, owing to its numerous advantages such as controlled release, targeted delivery, and efficient protection of encapsulated agents. Integration of microneedle technologies with nanomedicine has the potential to address current limitations in nanomedicine for drug delivery including relatively low therapeutic efficacy and poor patient compliance and enable theragnostic uses. In this Review, we first summarize representative types of nanomedicine and describe their broad applications. We then outline the current challenges faced by nanomedicine, with a focus on issues related to physical barriers, biological barriers, and patient compliance. Next, we provide an overview of microneedle systems, including their definition, manufacturing strategies, drug release mechanisms, and current advantages and challenges. We also discuss the use of microneedle-mediated nanomedicine systems for therapeutic and diagnostic applications. Finally, we provide a perspective on the current status and future prospects for microneedle-mediated nanomedicine for biomedical applications.

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Self-assembled carriers as drug delivery systems: Current characterization challenges and future prospects

Pantelić,

Ilić,

Nikolić

et al. 2023

Arhiv za farmaciju

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A review of recent publications reveals an increased interest in the so-called self-assembled carriers and their applicability in drug delivery via various routes of administration. Self-assembly denotes the process of rather spontaneous formation of ordered aggregates (sometimes under specific conditions-e.g., pH, temperature, ionic strength), via diverse interactions. This process, seen in many naturally occurring substances (polysaccharides, proteins, lipids), has inspired researchers to synthetize innovative self-assembling materials or combinations of existing ones. This paper provides a review of the recently investigated self-assembling materials and the carriers they form, often belonging to the sphere of pharmaceutical nanotechnology. Self-assembled carriers may provide enhanced stability, more efficient encapsulation and/or controlled delivery of active pharmaceutical ingredients. However, the diversity of geometries obtained (spheres, polyhedrals, ellipses, discs, porous structures, etc.) presents a significant characterization challenge, often requiring the application of several complementary techniques for proper evaluation of carrier size and morphology. Commonly utilized characterization techniques for investigating physico-chemical and certain biopharmaceutical properties are discussed, along with their advantages and disadvantages. Finally, the authors offer their critical opinion on the outlook of self-assembled drug carriers.

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pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer’s disease

Cited by 3 publications

References 50 publications

Synthesis, characterization, and biological evaluation of novel cinnamic acid derivatives: cinnamoyl-metronidazole ester and cinnamoyl-memantine amide

Synthesis, characterization, and biological evaluation of novel cinnamic acid derivatives: cinnamoyl-metronidazole ester and cinnamoyl-memantine amide

Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy

Self-assembled carriers as drug delivery systems: Current characterization challenges and future prospects

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