“…1 ). Generally, pH-responsive nanoparticles are fabricated either using acid-sensitive linkers or ionizable groups [ 30 ]. Fig.…”
Section: Targeting Of Common Attributes Of Tmementioning
confidence: 99%
“…The pH-dependent property of pHis is due to the presence of lone-pair electrons on the unsaturated nitrogen in the imidazole group of pHis. Our group previously reported a variety of pHis-based polymeric micelles for the delivery of doxorubicin (DOX) [ 30 – 33 ]. Poly (ethylene glycol) methyl ether acrylate-block poly(L-lysine)-block-poly(L-histidine) triblock co-polypeptides were synthesized for pH-responsive drug delivery.…”
Section: Targeting Of Common Attributes Of Tmementioning
BackgroundCancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors.Main bodyThe recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo.ConclusionTumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy.
“…1 ). Generally, pH-responsive nanoparticles are fabricated either using acid-sensitive linkers or ionizable groups [ 30 ]. Fig.…”
Section: Targeting Of Common Attributes Of Tmementioning
confidence: 99%
“…The pH-dependent property of pHis is due to the presence of lone-pair electrons on the unsaturated nitrogen in the imidazole group of pHis. Our group previously reported a variety of pHis-based polymeric micelles for the delivery of doxorubicin (DOX) [ 30 – 33 ]. Poly (ethylene glycol) methyl ether acrylate-block poly(L-lysine)-block-poly(L-histidine) triblock co-polypeptides were synthesized for pH-responsive drug delivery.…”
Section: Targeting Of Common Attributes Of Tmementioning
BackgroundCancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors.Main bodyThe recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo.ConclusionTumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy.
“…Therefore, poly(Histidine) (pHis) has been extensively used for the fabrication of pH-sensitive drug delivery nanosystems. Uthaman and his team (2018) have reported a variety of pHis-based polymeric micelles for the delivery of DOX [15,29,[46][47][48]. In addition to these, nanocarriers composed of amphiphilic, biocompatible chitosan polymeric micelles were used to deliver Nonsteroidal anti-inflammatory drug (NSAID) Ibuprofen in breast cancer therapy.…”
Section: Polymeric Micellesmentioning
confidence: 99%
“…Generally, pH-responsive nanoparticles are fabricated either using acid-sensitive linkers or ionizable groups [15]. A variety of pHsensitive nanoparticles have been designed in recent decades and have characteristic functionalities in the molecular structure, where pK a (negative logarithm of the acid dissociation constant) values are close to the tumor interstitial pH.…”
Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine. Nonetheless, the side-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remains to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.
“…Further DOX release could be triggered by low pH or by treatment with 10 mM of GSH, and fluorescence indicated that the nanomicelles could be biodistributed in the animal model within 72 hours and inhibit CT26 tumors. 130 Reduction-and pH-responsive nanomicelles, composed of poly(styrene-alt-maleic anhydride) and short PEG chains, were used for delivering drugs and PLK-1 siRNA. These micelles were coated with BSA to enhance their stability.…”
Hypoxia is one of the marked features of malignant tumors, which is associated with several adaptation changes in the microenvironment of tumor cells. Therefore, targeting tumor hypoxia is a research hotspot for cancer therapy. In this review, we summarize the developing chemotherapeutic drugs for targeting hypoxia, including quinones, nitroaromatic/nitroimidazole, N-oxides, and transition metal complexes. In addition, redox-responsive bonds, such as nitroimidazole groups, azogroups, and disulfide bonds, are frequently used in drug delivery systems for targeting the redox environment of tumors. Both hypoxia-activated prodrugs and redox-responsive drug delivery nanocarriers have significant effects on targeting tumor hypoxia for cancer therapy. Hypoxia-activated prodrugs are commonly used in clinical trials with favorable prospects, while redox-responsive nanocarriers are currently at the experimental stage.
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