pH/redox/thermo-stimulative nanogels with enhanced thermosensitivity via incorporation of cationic and anionic components for anticancer drug delivery

Duan, Lanlan; Wang, Yifeng; Zhang, Yuhong; Wang, Zhiguo; Li, Yulin; He, Peixin

doi:10.1080/00914037.2017.1323215

Cited by 12 publications

(8 citation statements)

References 48 publications

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“…The polymerization was carried out at 70°C for 4 h. These emulsions were subjected to dialysis using 50 mL ultrapure water for 3 consecutive days, then cryodesiccated, and then kept in a vacuum container for the following experiments, marked with PND‐BAC or PND‐MBA nanogels, as shown in Scheme A. PND‐BAC/DOX and PND‐MBA/DOX nanogels were prepared by a simple dialysis process, and the details can be found in the literature . The PND‐BAC nanogels' composition was investigated by Raman spectroscopy (Renishaw, inVia Raman, UK) at a 785 nm wavelength and FTIRspectroscopy (PerkinElmer, Spectrum One).…”

Section: Methodsmentioning

confidence: 99%

“…PND-BAC/DOX and PND-MBA/DOX nanogels were prepared by a simple dialysis process, and the details can be found in the literature. 14 The PND-BAC nanogels' composition was investigated by Raman spectroscopy (Renishaw, inVia Raman, UK) at a 785 nm wavelength and FTIRspectroscopy (PerkinElmer, Spectrum One).…”

Section: Synthesis Of Pnd-bac and Pnd-mba And Pnd-bac/doxmentioning

confidence: 99%

“…Therefore, this motivates the researchers to concentrate on the fabrication of a kind of sensitive polymer nanosystem that is capable of effective drug release upon internal/external triggering of the complex environment. It is known that the polymers based on N , N ′‐dimethylaminoethyl methacrylate (DMAEMA) could release the loaded drugs through the swelling behaviors due to its pH‐sensitive characteristics, which exhibited its biocompatibility and potential as drug carriers . Except for their biocompatibility, the polymer drug carriers should be degraded by biological stimuli gradually in the human body, thus releasing the package drugs because of the diffusion after degradation.…”

Section: Introductionmentioning

confidence: 99%

“…It is known that the polymers based on N,N 0 -dimethylaminoethyl methacrylate (DMAEMA) could release the loaded drugs through the swelling behaviors due to its pH-sensitive characteristics, which exhibited its biocompatibility and potential as drug carriers. [12][13][14] Except for their biocompatibility, the polymer drug carriers should be degraded by biological stimuli gradually in the human body, thus releasing the package drugs because of the diffusion after degradation. As we all know, a high amount of reducing compounds containing -SH is present in intracellular sites, such as mitochondria, cytoplasm, nucleus, and so on.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Gao

Duan

et al. 2019

J Biomedical Materials Res

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Stimuli‐sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this article, polymeric nanogel P (N‐isopropylacrylamide–N,N ′‐dimethylaminoethyl methacrylate [NIPAM–DMAEMA]) (PND) with pH/redox/thermo‐responsivenesses was synthesized by the in situ polymerization of NIPAM and DMAEMA for the controlled release of doxorubicin hydrochloride (DOX) and N,N ′‐bis(acryloyl)cystamine (BAC) and N,N ′‐methylenebisacrylamide (MBA) act as the crosslinkers, respectively. The structure, size, and zeta potential of PND‐BAC and PND‐MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND‐BAC/DOX and PND‐MBA/DOX nanogels were discussed in detail. Compared to PND‐MBA NGs, PND‐BAC nanogels have redox degradability due to the presence of the crosslinker BAC. After loading DOX, the PND‐BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2)% and thermo‐ and pH‐responsiveness as well as redox‐responsive in vitro release. These properties together with excellent environmentally sensitive properties make PND‐BAC as an attractive candidate for application in drug nanocarriers for the targeted drug delivery of model payloads. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1195–1203, 2019.

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of Pnd-bac and Pnd-mba And Pnd-bac/doxmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Gao

Duan

et al. 2019

J Biomedical Materials Res

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“…The triple-responsive PNDA nanogels could more effectively encapsulate drug (encapsulation efficiency ∼89%) and displayed a higher thermosensitivity and higher cumulative release efficiency as compared with PND nanogels. In vitro experiments investigated that the DOX-loaded PNDA nanogels possessed low side effects and high cytotoxicity to A549 cancer cells . Inspired by this work, Gao et al synthesized PND-BAC and PND-MBA nanogels, which were cross-linked with reducing sensitive and nonreducing sensitive cross-linker .…”

Section: Multiresponsive Nanogels For Cancer Therapymentioning

confidence: 99%

Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

Wang

Gao

Fan

et al. 2021

ACS Appl. Mater. Interfaces

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Owing to the distinctive constituents of tumor tissue from those healthy organs, nanomedicine strategies show significant potentials in smart drug delivery. Nowadays, stimuli-responsive nanogels are playing increasingly important roles in the application of cancer therapy because of their sensitivity to various internal or external physicochemical stimuli, which exhibit site-specific and markedly enhanced drug release. Besides, nanogels are promising as drug carriers because of their porous structures, good biocompatibility, large surface area, and excellent capability with drugs. Taking advantage of multiresponsiveness, recent years have witnessed the rapid evolution of stimulus-responsive nanogels from monoresponsive to multiresponsive systems; however, there lacks a comprehensive review summarizing these reports. In this Review, we discuss the properties, synthesis, and characterization of nanogels. Moreover, tumor microenvironment and corresponding designing strategies for stimuli-response nanogels, both exogenous (temperature, magnetic field, light) and endogenous (pH, biomolecular, redox, ROS, pressure, hypoxia) are summarized on the basis of the recent advances in multistimuli-responsive nanogel systems. Nanogel and two-dimensional material composites show excellent performance in the field of constructing multistimulus-responsive nanoparticles and precise intelligent drug release integrated system for multimodal cancer diagnosis and therapy. Finally, potential progresses and suggestions are provided for the further design of hybrid nanogels based on emerging two-dimensional materials.

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A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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pH/redox/thermo-stimulative nanogels with enhanced thermosensitivity via incorporation of cationic and anionic components for anticancer drug delivery

Cited by 12 publications

References 48 publications

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Preparation of thermo/redox/pH‐stimulative poly(N‐isopropylacrylamide‐co‐N,N′‐dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors

Strategic Design of Intelligent-Responsive Nanogel Carriers for Cancer Therapy

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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