pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery

Yang, Qing; Wang, Qianqian; Fan, Peiwei; Wang, Lifeng; Yan, Donghang; Lin, Kaifeng; Xiao, Feng‐Shou

doi:10.1021/cm051198v

Cited by 472 publications

(268 citation statements)

References 46 publications

Supporting

Mentioning

262

Contrasting

Unclassified

Order By: Relevance

“…pH-responsive nanomateials provide an alternate mechanism for release, relying on the acidic condition inside tumor and inflamed tissues (pH $ 6.8) and cellular compartments including endosomes (pH $ 5.5-6) and lysosomes (pH $ 4.5-5.0). [101] Toward this end, magnetic nanoparticles (Fe 3 O 4 ) were covalently functionalized with doxorubicin (DOX), an anticancer drug, through an acid-labile hydrazone linker. [102] The carrier was then encapsulated with thermosensitive polymer for temperature-controlled release of the drug.…”

Section: Nanoparticles As Drug Delivery Systemsmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

View full text Add to dashboard Cite

show abstract

Section: Nanoparticles As Drug Delivery Systemsmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

View full text Add to dashboard Cite

show abstract

“…The porous biomaterials with large surface areas and large pore volumes are good candidates for drug delivery systems [2][3][4]. Drug carriers require biocompatibility and well defined morphological characteristics, and here the sol-gel methods of mesoporous silica materials production offer the simplicity of preparation and ease of control of their pore sizes adapted to the different drug molecules [5,6].…”

Section: Introductionmentioning

confidence: 99%

Pore ordering in mesoporous matrices induced by different directing agents

et al. 2014

View full text Add to dashboard Cite

Mesoporous silica particles of MCM-41 type were synthesized by sol-gel method from tetraethyl orthosilicate (TEOS) in 2-methoxyethanol and deionized water mixture in base conditions at room temperature. Ammonia or sodium hydroxides were used as catalysts and cetyl-trimethylammonium bromide (CTAB) and n-dodecyl-trimethylammonium bromide (DTAB) as structure directing agents. The porosities and the ordered structure have been analyzed using transmission and scanning electron microscopy, small angle neutron and Xray diffraction, nitrogen adsorption, thermal analysis and FTIR spectroscopy. The samples consist of spherical particles of sub-micrometer size, with radially arranged pores. The comparison of the effect of the different surfactants and catalysts shows that by varying the surfactant type and their proportion, the pore sizes can be controlled. As compared to the commonly used ammonia catalyst, the use of NaOH as catalyst results in a much smaller porosity of the as-prepared materials. These materials are not resisting to the heat treatment at 700 ºC used for the template removal, and the ordered porous structure is completely lost.

show abstract

“…For example, a hydrophobic character can be imparted to the silica surface by the attachment of unreactive groups (e.g. trimethylsilyl negatively charged groups (like carboxyl 21,22 ), positively charged ones (as protonated amino groups 16,17,23 ) or reactive groups (as epoxy 24 or thiol residues…”

Section: -5mentioning

confidence: 99%

Mesoporous silica coatings for controlled release of the antibiotic ciprofloxacin from implants

et al. 2011

View full text Add to dashboard Cite

To generate bioactive coatings for medical implants, a novel procedure has been developed using a coating of mesoporous silica for controlled drug delivery. Plain glass slides were used as substrates. The mesoporous coatings were then loaded with the antibacterial drug ciprofloxacin. The drug release kinetics were investigated in a physiological buffered solution. The drug loading capacity of the unmodified mesoporous coatings was low but could be increased nearly ten-fold (to about 2 mg cm À2 of the macroscopic surface) by functionalizing the mesoporous surface with sulfonic acid groups. To achieve a controlled drug release over an extended time period, further coatings were added. Covering the surface of the drug loaded mesoporous silica layer by dip-coating with bis(trimethoxysilyl)hexane resulted in an organosiloxane layer which retarded the release for up to 30 days. By an additional evaporation coating with dioctyltetramethyldisilazane, the release of ciprofloxacin was prolonged for up to 60 days. The biocompatibility of the different coatings was tested in cell culture assays. The presence of the additional silane-derived hydrophobic coatings somewhat reduced the biocompatibility. The antibacterial efficacy of the materials was demonstrated by using clinically relevant biofilm-forming pathogenic bacteria. A test where the sequential release of ciprofloxacin (in 2 days intervals) and the bacterial viability were tested in parallel showed good concordance in the results. The material where a sulfonate-functionalized mesoporous silica layer is loaded with ciprofloxacin and then coated by an organosiloxane layer derived from bis(trimethoxysilyl)hexane showed the best results with regard to antibacterial efficacy and will further be tested in animal experiments.

show abstract

pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery

Cited by 472 publications

References 46 publications

Applications of Nanoparticles in Biology

Applications of Nanoparticles in Biology

Pore ordering in mesoporous matrices induced by different directing agents

Mesoporous silica coatings for controlled release of the antibiotic ciprofloxacin from implants

Contact Info

Product

Resources

About