pH-responsive catalytic mesocrystals for chemodynamic therapy via ultrasound-assisted Fenton reaction

Chen, Jian; Wang, Xiaobo; Liu, Yibiao; Liu, Huili; Gao, Fengli; Lan, Chong; Yang, Baocheng; Zhang, Shouren; Gao, Yongju

doi:10.1016/j.cej.2019.03.061

Cited by 60 publications

(33 citation statements)

References 28 publications

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“…Given the enhanced ability of ultrasound to Fenton/Fenton‐like reaction, ultrasound‐assisted ECDT nanotherapeutic agents are receiving increasing research attention. [ 94 ] Based on this concept, we have synthesized a class of perovskite‐type bimetallic bismuth ferrite (BFO) nanocatalysts for ultrasound‐reinforced Fenton reaction. [ 95 ] This nanomedicine is proposed for H 2 O 2 and ultrasound dual‐responsive logic‐gate ECDT ( Figure A).…”

Section: Emerging Strategies To Reinforce Fenton/fenton‐like Reactions For Enhanced Chemodynamic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective tumor treatment. However, the limited intratumoral Fenton reaction efficiency restricts the therapeutic efficacy of CDT. Recent years have witnessed the impressive development of various strategies to increase the efficiency of intratumoral Fenton reaction. The introduction of these reinforcement strategies can dramatically improve the treatment efficiency of CDT and further promote the development of enhanced CDT (ECDT)‐based multimodal anticancer treatments. In this review, the authors systematically introduce these reinforcement strategies, from their basic working principles, reinforcement mechanisms to their representative clinical applications. Then, ECDT‐based multimodal anticancer therapy is discussed, including how to integrate these emerging Fenton reinforcement strategies for accelerating the development of multimodal anticancer therapy, as well as the synergistic mechanisms of ECDT and other treatment methods. Eventually, future direction and challenges of ECDT and ECDT‐based multimodal synergistic therapies are elaborated, highlighting the key scientific problems and unsolved technical bottlenecks to facilitate clinical translation.

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Section: Emerging Strategies To Reinforce Fenton/fenton‐like Reactions For Enhanced Chemodynamic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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“…to regulate specific release. [144,145] But these systems can not completely achieve "zero accumulation" and "zero release" in normal tissues. Therefore, to achieve "zero damage" to normal tissue is a challenge for design and construction of nanocatalysts for CDT in the future.…”

Section: Discussionmentioning

confidence: 99%

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Zhang

Wan

et al. 2021

Adv Healthcare Materials

154

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Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal therapy, are developed and used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton-like reaction to generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O 2 ) to kill cancer cells, which displays promising therapeutic potentials for tumor treatment. However, the low catalytic efficiency and off-target side effects of Fenton reaction limit the biomedical application of CDT. In this regard, various strategies are implemented to potentiate CDT against tumor, including retrofitting the tumor microenvironment (e.g., increasing H 2 O 2 level, decreasing reductive substances, and reducing pH), enhancing the catalytic efficiency of nanocatalysts, and other strategies. This review aims to summarize the development of CDT and summarize these recent progresses of nanocatalyst-mediated CDT for antitumor application. The future development trend and challenges of CDT are also discussed.

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“…Several strategies have been developed to elevate the local H 2 O 2 level in the tumor microenvironment, among which the introduction of pre-reaction with H 2 O 2 as the product is the mostly adopted approach. [148][149][150][151] Therefore, the rational design of sequential reactions is applicable for H 2 O 2 self-supplying Fenton reaction and enhanced CDT. For instance, we loaded both natural glucose oxidase (GOD) and ultrasmall Fe 3 O 4 (as Fenton catalysts) into dendritic silica nanoparticles with large mesopores (Figure 11a).…”

Section: Chemodynamic Therapymentioning

confidence: 99%

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

et al. 2021

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Figure 3. a) Scheme for the constructed Fe(III)/TPPS nanosonosensitizer for synergistic sonotheranostics by RGD-enabled tumor targeting, downregulated SOD2 expression, GSH depletion, Fenton reaction-triggered hydroxyl radicals and SDT. Reproduced with permission. [38] Copyright 2019, Wiley-VCH. b) Schematic illustration of the design principle and mechanism of combinatorial SDT and immunotherapy, including nanosonosensitizer-enabled and SDT-induced antitumor immune responses and checkpoint blockade for tumor immunotherapy. Reproduced under the terms of the CC-BY Creative Commons Attribution 4.

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pH-responsive catalytic mesocrystals for chemodynamic therapy via ultrasound-assisted Fenton reaction

Cited by 60 publications

References 28 publications

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

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