pH-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin

Kalhapure, Rahul S.; Jadhav, Mahantesh; Rambharose, Sanjeev; Mocktar, Chunderika; Singh, Sima; Renukuntla, Jwala; Govender, Thirumala

doi:10.1016/j.colsurfb.2017.07.049

Cited by 65 publications

(32 citation statements)

References 32 publications

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“…The high hydrophilic nature of vancomycin was cited as the reason it did not produce the desired sustained release, but sustained‐release formulations such as these could potentially reduce vancomycin nephrotoxicity if site‐concentrated therapy is desired. In another study, vancomycin loaded pH‐responsive chitosan nanoparticles for controlled and targeted delivery of vancomycin showed an increase in vancomycin release at pH 6.5 compared to pH 7.4 and reduced MRSA burden 8‐fold compared to vancomycin 137 …”

Section: Potential Strategies For Preventionmentioning

confidence: 97%

Vancomycin‐Induced Kidney Injury: Animal Models of Toxicodynamics, Mechanisms of Injury, Human Translation, and Potential Strategies for Prevention

et al. 2020

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Vancomycin is a recommended therapy in multiple national guidelines. Despite the common use, there is a poor understanding of the mechanistic drivers and potential modifiers of vancomycin-mediated kidney injury. In this review, historic and contemporary rates of vancomycin-induced kidney injury (VIKI) are described, and toxicodynamic models and mechanisms of toxicity from preclinical studies are reviewed. Aside from known clinical covariates that worsen VIKI, preclinical models have demonstrated that various factors impact VIKI, including dose, route of administration, and thresholds for pharmacokinetic parameters. The degree of acute kidney injury (AKI) is greatest with the intravenous route and higher doses that produce larger maximal concentrations and areas under the concentration curve. Troughs (i.e., minimum concentrations) have less of an impact. Mechanistically, preclinical studies have identified that VIKI is a result of drug accumulation in proximal tubule cells, which triggers cellular oxidative stress and apoptosis. Yet, there are several gaps in the knowledge that may represent viable targets to make vancomycin therapy less toxic. Potential strategies include prolonging infusions and lowering maximal concentrations, administration of antioxidants, administering agents that decrease cellular accumulation, and reformulating vancomycin to alter the renal clearance mechanism. Based on preclinical models and mechanisms of toxicity, we propose potential strategies to lessen VIKI.

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Section: Potential Strategies For Preventionmentioning

confidence: 97%

Vancomycin‐Induced Kidney Injury: Animal Models of Toxicodynamics, Mechanisms of Injury, Human Translation, and Potential Strategies for Prevention

et al. 2020

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“…Similarly, another pH responsive nanosystem based on the triblock copolymer of poly(ethylene glycol)‐ b ‐polycaprolactone‐ b ‐poly(β‐amino ester) (PEG‐ b ‐PCL‐ b ‐PAE) was reported, and the PAE blocks underwent charge switching from negative to positive due to the localized acidity caused by the bacterial infection, and triggered the release of encapsulated vancomycin to kill bacteria in subcutaneous infection sites . Afterward, many responsive and biodegradable micelle systems based on polycarbonates, polyurethane with disulfide linkages, biodegradable dendrimers, acid cleavable lipids, and polysaccharides have been reported as antibiotics carriers for the treatment of bacterial infections. Moreover, the co‐delivery of silver nanoparticles (AgNPs) and curcumin in the micelles fabricated by a diblock copolymer poly(aspartic acid)‐ b ‐poly(ε‐caprolactone) (PAsp‐ b ‐PCL) was also reported to enhance antibacterial efficacy …”

Section: Biodegradable Polymeric Nanosystems Containing Antibioticsmentioning

confidence: 99%

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Ding

Wang

Tong

2019

Small

161

108

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Figure 17. a) Schematic illustration for the fabrication of chlorhexidine diacetate (CHX)-loaded antibacterial nanogels for hemostasis and wound healing applications. b) Wound healing processes after treated with different materials. Reproduced with permission. [109] Figure 25. a) Schematic illustration, b) synthetic route, and c) TEM images of phosphonium-functionalized polymer micelles. Reproduced with permission. [126]

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“…FUnder the above strategies, cells from different sources can be directed to differentiate into specific cells and eventually achieve tooth regeneration potential applications of this kind of materials were prospected [50]. pH-responsive release systems have special significance in tissue regeneration due to pH variations in human tissues and organs, which has begun to be applied to diagnosis [51] and treatment of some diseases [52]. Some pH sustained-release materials have been invented, but there is still a lack of in vivo experiments to prove their application in regenerative medicine [53,54].…”

Section: The Ph-responsive Release Systemmentioning

confidence: 99%

Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

Huang

Ren

et al. 2019

Stem Cell Rev and Rep

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Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.

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pH-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin

Cited by 65 publications

References 32 publications

Vancomycin‐Induced Kidney Injury: Animal Models of Toxicodynamics, Mechanisms of Injury, Human Translation, and Potential Strategies for Prevention

Vancomycin‐Induced Kidney Injury: Animal Models of Toxicodynamics, Mechanisms of Injury, Human Translation, and Potential Strategies for Prevention

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

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