pH-responsive co-delivery of doxorubicin and saffron via cross-linked chitosan/laponite RD nanoparticles for enhanced-chemotherapy

Heragh, Bagher Kazemi; Taherinezhad, Hakimeh; Mahdavinia, Gholam Reza; Javanshir, Shahrzad; Labib, Parisa; Ghasemsolb, Sara

doi:10.1016/j.mtcomm.2022.104956

Cited by 9 publications

(3 citation statements)

References 64 publications

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“…4 (c) and (d), the pore size is smaller compared to the previous type of particles. This reduction in pore size may be attributed to the crosslinking between TPP and Chitosan [ [56] , [57] , [58] ]. It's important to note that during the cutting and preparation of the particle for freeze-drying, tension was exerted on the particle, causing its layers to separate.…”

Section: Resultsmentioning

confidence: 99%

Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate

Aghelinejad,

Golshan Ebrahimi

2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate

Aghelinejad,

Golshan Ebrahimi

2024

Heliyon

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“…Chitosan formulations have been used to transport natural and herbal components, of which compounds such as curcumin and quercetin are useful in counteracting cancer [217,218]. Li et al studied the dual-stimuli chitosan hydrogel for curcumin distribution in solid tumors.…”

Section: Drug Delivery In Cancer Treatmentmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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“…The system provided sustained drug release and lower cytotoxicity than using DOX alone. In particular, chitosan, a cationic, naturally derived polysaccharide from chitin, has been an attractive choice in the development of nanogels for the delivery of numerous drugs, such as DOX [ 8 , 9 , 10 , 11 , 12 ], curcumin (CUR) [ 13 , 14 ], 5-fluorouracil [ 15 ], and paclitaxel [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

Veloso,

Marta,

Rodrigues

et al. 2023

Pharmaceutics

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In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications.

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pH-responsive co-delivery of doxorubicin and saffron via cross-linked chitosan/laponite RD nanoparticles for enhanced-chemotherapy

Cited by 9 publications

References 64 publications

Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate

Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

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