pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells

Dong, Da-Wen; Xiang, Bingren; Gao, Wei; Yang, Zhenzhen; Li, Jingquan; Qi, Xian

doi:10.1016/j.biomaterials.2013.03.018

Cited by 117 publications

(82 citation statements)

References 34 publications

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“…Using this bond, DOX molecules were conjugated to diverse novel drug carriers with moderate antitumor efficacy. 21,22 On the other hand, DOX could be conjugated with an amide bond at a 3′-C position for the preparation of enzymatically cleavable prodrugs. 23,24 In this article, we prepared the DOX-linkerFbg microspheres with different linkers to evaluate their feasibility as a novel cancer drug delivery system.…”

Section: Discussionmentioning

confidence: 99%

Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

Joo¹,

Park²,

An³

2015

IJN

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In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine–glycine–aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX–linker–Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery.

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Section: Discussionmentioning

confidence: 99%

Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

Joo¹,

Park²,

An³

2015

IJN

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“…RNAi represents a novel way to treat diseases that use double-stranded RNAs that undertake the function of regulating gene expression without any permanent effect on the genome. 1,2 However, although siRNA interference is valid, a safe and efficient delivery vector is still a major hurdle to the further development of RNAi therapeutics because of its large molecular weight, strong negative charge, and instability under nuclease and serum proteins, as well as its low transfection efficiency. 3,4 In recent years, interest has grown in developing effective transport carriers to overcome these disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

Li¹,

Shen²,

Chen³

et al. 2015

IJN

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Engineering a safe and high-efficiency delivery system for efficient RNA interference is critical for successful gene therapy. In this study, we designed a novel nanocarrier system of polyethyleneimine (PEI)-modified Fe 3 O 4 @SiO 2 , which allows high efficient loading of VEGF small hairpin (sh)RNA to form Fe 3 O 4 @SiO 2 /PEI/VEGF shRNA nanocomposites for VEGF gene silencing as well as magnetic resonance (MR) imaging. The size, morphology, particle stability, magnetic properties, and gene-binding capacity and protection were determined. Low cytotoxicity and hemolyticity against human red blood cells showed the excellent biocompatibility of the multifunctional nanocomposites, and also no significant coagulation was observed. The nanocomposites maintain their superparamagnetic property at room temperature and no appreciable change in magnetism, even after PEI modification. The qualitative and quantitative analysis of cellular internalization into MCF-7 human breast cancer cells by Prussian blue staining and inductively coupled plasma atomic emission spectroscopy analysis, respectively, demonstrated that the Fe 3 O 4 @SiO 2 /PEI/VEGF shRNA nanocomposites could be easily internalized by MCF-7 cells, and they exhibited significant inhibition of VEGF gene expression. Furthermore, the MR cellular images showed that the superparamagnetic iron oxide core of our Fe 3 O 4 @SiO 2 /PEI/VEGF shRNA nanocomposites could also act as a T 2 -weighted contrast agent for cancer MR imaging. Our data highlight multifunctional Fe 3 O 4 @SiO 2 /PEI/VEGF shRNA nanocomposites as a potential platform for simultaneous gene delivery and MR cell imaging, which are promising as theranostic agents for cancer treatment and diagnosis in the future.

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“…Dong et al [27] reported multifunctional PHD/PPF/siRNA complexes by using a one-step assembly of prefunctionalized polymers PEI-HZ-DOX (PHD) and PEI-PEG-folate (PPF) with siRNA. PHD was a conjugate of PEI (polyethylenimine) with DOX by a pH-responsive hydrazone linkage with the ability of pH-controlled drug release.…”

Section: Organic-materials-based Ph-responsive Drug-delivery Systemsmentioning

confidence: 99%

pH‐Responsive Drug‐Delivery Systems

Zhu

Chen

2014

Chemistry An Asian Journal

177

104

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In many biomedical applications, drugs need to be delivered in response to the pH value in the body. In fact, it is desirable if the drugs can be administered in a controlled manner that precisely matches physiological needs at targeted sites and at predetermined release rates for predefined periods of time. Different organs, tissues, and cellular compartments have different pH values, which makes the pH value a suitable stimulus for controlled drug release. pH-Responsive drug-delivery systems have attracted more and more interest as "smart" drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy. This focus review is not intended to offer a comprehensive review on the research devoted to pH-responsive drug-delivery systems; instead, it presents some recent progress obtained for pH-responsive drug-delivery systems and future perspectives. There are a large number of publications available on this topic, but only a selection of examples will be discussed.

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pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells

Cited by 117 publications

References 34 publications

Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

pH‐Responsive Drug‐Delivery Systems

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