pH-responsive drug release system of Cu2+-modified ammoniated TiO2 nanotube arrays

Zhang, Tao; Xie, Chunling; Liu, Yan; Zhang, Fengfen; Xiao, Xiufeng

doi:10.1016/j.matlet.2017.12.080

Cited by 14 publications

(12 citation statements)

References 11 publications

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“…Therefore, the variation in pH can be the trigger to control the release of the antibacterial agent 119–121. Chemical bonds (eg, Schiff base bonds,122 acetal linkers,123 and coordination bonds124-126), which are stable under neutral conditions whereas they dissociate at lower pH, are essential in the self-response systems. By fabricating acid-sensitive coatings or simply binding agents to TNTs via these bonds, pH-triggered release retains more agents in the neutral environment, while accelerating release in the acidified environment.…”

Section: Doping With Other Antibacterial Agentsmentioning

confidence: 99%

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

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Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.

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Section: Doping With Other Antibacterial Agentsmentioning

confidence: 99%

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

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“…As bacterial metabolism produces lactic acid and acetic acid, the pH drops in the vicinity of bacterial infections can be used to trigger the release of bactericidal agents. Chemical bonds such as Schiff base, acetal linkage, and metal ion coordination bonds ,, that are stable under neutral conditions but labile at lower pH are often utilized to realize the pH-triggered release. Wang et al designed a pH-responsive coordinated polymer (CP)/amine-functionalized titania nanotubes (TNTs-NH 2 ) coating for titanium implants.…”

Section: Bactericidal Implant Surface Modificationsmentioning

confidence: 99%

Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings

Ghimire

Song

2021

ACS Appl. Mater. Interfaces

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Despite advanced implant sterilization and aseptic surgical techniques, periprosthetic bacterial infection remains a major challenge for orthopedic and dental implants. Bacterial colonization/biofilm formation around implants and their invasion into the dense skeletal tissue matrices are difficult to treat and could lead to implant failure and osteomyelitis. These complications require major revision surgeries and extended antibiotic therapies that are associated with high treatment cost, morbidity, and even mortality. Effective preventative measures mitigating risks for implant-related infections are thus in dire need. This review focuses on recent developments of anti-periprosthetic infection strategies aimed at either reducing bacterial adhesion, colonization, and biofilm formation or killing bacteria directly in contact with and/or in the vicinity of implants. These goals are accomplished through antifouling, quorum-sensing interfering, or bactericidal implant surface topographical engineering or surface coatings through chemical modifications. Surface topographical engineering of lotus leaf mimicking super-hydrophobic antifouling features and cicada wing-mimicking, bacterium-piercing nanopillars are both presented. Conventional physical coating/passive release of bactericidal agents is contrasted with their covalent tethering to implant surfaces through either stable linkages or linkages labile to bacterial enzyme cleavage or environmental perturbations. Pros and cons of these emerging anti-periprosthetic infection approaches are discussed in terms of their safety, efficacy, and translational potentials.

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“…Among these, the pH-responsive delivery systems have been extensively studied [9][10][11][12][13]. Until recently, a novel coordination bond-based pH-responsive drug delivery system, which enabled the release of drug molecules by small changes of pH, was developed [14][15][16]. The formation and cleavage of metal ions and ligand coordination bonds are sensitive to pH because metal ions and protons (Lewis acids) compete with each other to bind to Lewis base ligands.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive TiO₂ Nanotube Drug Delivery System Based on Iron Coordination

Liu

Xie

Zhang

et al. 2019

Journal of Nanomaterials

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Nanostructured materials play a fundamental role in orthopedic research owing to their outstanding properties and excellent biocompatibility. Titania nanotube (TNT) arrays engineered by electrochemical anodization process have been extensively explored and used as effective carriers for controlled drug delivery. In this study, we proposed a drug delivery system based on coordination bond. Iron (III), Fe3+, on the nanotube surface can effectively bind to alendronate sodium (NaAL), a drug for the treatment of osteoporosis, through coordination bonds, which can be formed or broken through the change of pH, and thus can be controlled by pH. The pH-responsive system was prepared by three-step procedure: (i) fabrication of TNTs by electrochemical anodization, (ii) modification of amino groups on the surface of nanotubes by hydrothermal method, and (iii) amino-functionalized nanotubes by Fe3+ solution soak. The Fe-modified TNTs not only allowed alendronate-loading content of up to 50.2% by weight, which is significantly higher than most drug delivery systems previously reported, but also delayed and prolonged drug release. Moreover, in vitro drug release experiments demonstrated that coordination bond-based TNT system may have great potential applications in clinical use.

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pH-responsive drug release system of Cu2+-modified ammoniated TiO2 nanotube arrays

Cited by 14 publications

References 11 publications

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings

pH-Responsive TiO₂ Nanotube Drug Delivery System Based on Iron Coordination

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pH-responsive drug release system of Cu2+-modified ammoniated TiO2 nanotube arrays

Cited by 14 publications

References 11 publications

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Anti-Periprosthetic Infection Strategies: From Implant Surface Topographical Engineering to Smart Drug-Releasing Coatings

pH-Responsive TiO2 Nanotube Drug Delivery System Based on Iron Coordination

Contact Info

Product

Resources

About

pH-Responsive TiO₂ Nanotube Drug Delivery System Based on Iron Coordination