pH-responsive dual-functional hydrogel integrating localized delivery and anti-cancer activities for highly effective therapy in PDX of OSCC

Liu, Tiannan; Du, Yu; Yan, Yujie; Song, Shaojuan; Qi, Jiajia; Xia, Xin; Hu, Xiaopei; Chen, Qianming; Liu, Jiang; Zeng, Xin; Zhao, Hang

doi:10.1016/j.mattod.2022.12.009

Cited by 29 publications

(13 citation statements)

References 71 publications

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“…Stimuli-responsive materials capable of shape deformation, color changing, and locomotion in response to humidity, − light, − heat, − pH, , or magnetic fields, , have attracted great attention owing to their potential for artificial muscles, − flexible robots, , and sensors. , Light is pollution-free and can provide energy to targets remotely. The wavelength, intensity, and polarization direction of light can be adjusted to control the dynamic behaviors of the soft actuators.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive Non-Cross-Linking Film Actuator that Bends Away from a Light Source

Yang,

Zhang

2023

Macromolecules

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Azobenzene-based photoresponsive polymer film actuators normally bend toward an ultraviolet (UV) source, in which their photosensitive mesogens are stabilized in cross-linking polymer networks. Herein, we synthesize a non-cross-linking liquid-crystalline (LC) polymer film actuator, in which the photoresponsive azobenzene mesogens are aligned in a perpendicular direction to the non-cross-linking polymer chains. Upon exposure to UV light (λ = 365 nm), the trans-to-cis isomerization generates expanding strength along the parallel direction with respect to the polymer main chains, which causes the film actuator to bend away from the light source. After prestretching the film actuator at 120 °C to enhance its perpendicular alignments of the azobenzene mesogens, its photoresponsive performance can be improved. As a result, the film actuator shows flexible and multifarious motions not only in air but also in liquid environments, making it more adaptable to sensing systems, soft robots, and artificial muscles.

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Section: Introductionmentioning

confidence: 99%

Photoresponsive Non-Cross-Linking Film Actuator that Bends Away from a Light Source

Yang,

Zhang

2023

Macromolecules

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“…These bonds can be disrupted or cleaved at specific pH levels, leading to degradation or dissociation of the carriers. To date, various TME acidity-sensitive liposomes, − extracellular vesicles (EVs), − hydrogels, − metal–organic frames (MOFs), − and polymers have been developed. Polymers have attracted significant attention in the field of cancer therapy due to their ease of synthesis, large-scale production, chemical flexibility, improved stability, and long shelf life since the 1960s. − Clinical studies of polymers for cancer treatment date back to 1994 with the first clinically studied water-soluble polymer-drug conjugate for cancer therapy: PK1, which links DOX to the HPMA copolymer backbone via the lysosomal degradable sequence Gly-Phe-Leu-Gly (GFLG). , Additionally, PEGylation of drugs has been used to improve drug delivery system stability.…”

Section: Introduction and Scopementioning

confidence: 99%

Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity

Shi,

Ma,

Zhang

et al. 2023

Chem. Mater.

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Cancer therapy is a global biomedical challenge, and a number of promising anticancer therapeutics, such as small-molecule drugs, proteins, nucleic acids, photothermal agents, etc., have been developed or are in development. However, the direct administration of anticancer therapeutics often fails to achieve the desired therapeutic efficacy due to their low bioavailability and poor tissue selectivity, leading to relapse or severe side effects such as immunosuppression, chronic inflammatory responses, mutagenesis, and long-term tissue dysfunction. Polymers offer multiple advantageous properties for the delivery of anticancer therapeutics but are generally poorly targeted to the tumor microenvironment (TME). The relatively lower acidity of the TME compared to normal tissue provides an intrinsic yet highly specific trigger for the development of polymers for the targeted delivery of anticancer therapeutics. Here, we summarize the exquisite strategies for the synthesis of TME acidity-sensitive polymers, elucidate the mechanisms of the polymers’ response to TME acidity, and highlight the applications of the polymers for the delivery of various anticancer therapeutics. Moreover, the potential challenges in translating the polymers into clinical practice are discussed.

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“…However, chemotherapy drugs destroy cancer cells and attack healthy cells, posing a significant challenge to accurate diagnosis and treatment efficacy . Therefore, drug delivery approaches for localized chemotherapeutic delivery with an easy drug encapsulation process, controlled biorelated stimuli responsiveness, sustained drug concentration at the tumor site, and high therapeutic efficacy with minor side effects are vital in cancer treatment. , …”

Section: Introductionmentioning

confidence: 99%

“…2 Therefore, drug delivery approaches for localized chemotherapeutic delivery with an easy drug encapsulation process, controlled biorelated stimuli responsiveness, sustained drug concentration at the tumor site, and high therapeutic efficacy with minor side effects are vital in cancer treatment. 3,4 Hydrogels developed from novel biomaterials have received tremendous attention in biomedical applications including implants, 5 tissue scaffolds, 6,7 wound dressing, 8 and drug delivery, 9,10 owing to their desirable inherent features such as high water content, biocompatibility, biodegradability, high permeability, and tunable physicochemical properties. 11 Among them, stimulus-responsive hydrogels integrating selective drug delivery for highly effective therapy are attractive due to their ability to respond to external stimuli such as ultrasound, pH, temperature, light, enzymes, and reactive oxygen species.…”

Section: ■ Introductionmentioning

confidence: 99%

“…11 Among them, stimulus-responsive hydrogels integrating selective drug delivery for highly effective therapy are attractive due to their ability to respond to external stimuli such as ultrasound, pH, temperature, light, enzymes, and reactive oxygen species. Inspired by the acidic tumor microenvironment, 3 transient polymer hydrogels based on reversible pHsensitive covalent bonds or supramolecular interactions have been developed to construct intelligent systems for cancer drug release.…”

Section: ■ Introductionmentioning

confidence: 99%

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Dual-Cross-Linked PEI/PVA Hydrogel for pH-Responsive Drug Delivery

Wu,

Li,

Han

et al. 2023

Biomacromolecules

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Herein, a pH-responsive dual cross-linked hydrogel for controlled drug release is presented. The hydrogel was constructed with reversible borate ester bonds and crystalline poly(vinyl alcohol). By changing the environmental pH, its physicochemical characteristics, including rheological properties, mechanical properties, microstructural features, and the biocompatibility of the gels, were evaluated. The gels at tumor acidic conditions exhibited swelling and lower compressive strength and modulus than those in a physiological environment, which was attributed to the pH-responsive borate ester bonds and the protonation of amine groups on the PEI polyelectrolyte. Importantly, the drug-encapsulated biocompatible hydrogel showed sustained and increased release under an acidic environment, and it followed the Fickian diffusion mechanism. Therefore, it exemplifies that borate ester bond-based pH-responsive biomaterials have high promise in biomedical research, especially for drug delivery.

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pH-responsive dual-functional hydrogel integrating localized delivery and anti-cancer activities for highly effective therapy in PDX of OSCC

Cited by 29 publications

References 71 publications

Photoresponsive Non-Cross-Linking Film Actuator that Bends Away from a Light Source

Photoresponsive Non-Cross-Linking Film Actuator that Bends Away from a Light Source

Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity

Dual-Cross-Linked PEI/PVA Hydrogel for pH-Responsive Drug Delivery

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