pH‐Responsive Hydrogel With an Anti‐Glycation Agent for Modulating Experimental Periodontitis

Yu, Min‐Teh; Chang, Chih Yeun; Chao, Yi Chi; Jheng, Yi Han; Yang, Connie; Liao, Ning; Yu, Shan Huey; Yu, Xin; LIu, Dean-Mo; Chang, Po Chun

doi:10.1902/jop.2016.150542

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…As shown in Figure C, the release of drug was greatly accelerated in the first 2 days at pH 5.5 because of the rapid dissolution of chitosan. The burst release of PTB on the first day was prevented compared to our previous investigation of a chitosan‐based hydrogel . In a neutral environment (pH 7.4), approximately 50% of the drug was still in the nanospheres after 1 week, which suggested that the nanospheres were capable of withholding drug release in a physiologically healthy environment.…”

Section: Discussionmentioning

confidence: 99%

“…This study aimed to develop a pH‐responsive drug delivery system with a more sustainable carrier molecule than hydrogel entirely based on the amphiphilic chitosan polymer . Drugs were encapsulated with PLGA and covered with chitosan in a nanosphere.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, our research team developed a chitosan-based pH-responsive hydrogel encapsulating PTB and showed favorable results for facilitating the recovery of experimental periodontitis. 25 However, during periodontitis progression, inflammation could be more severe and lead to greater fluctuations of pH levels that might compromise the sustainability of molecules in the chitosan-based carrier.…”

Section: Introductionmentioning

confidence: 99%

“…This study aimed to develop a pH-responsive drug delivery system with a more sustainable carrier molecule than hydrogel entirely based on the amphiphilic chitosan polymer. 25 Drugs were encapsulated with PLGA and covered with chitosan in a nanosphere. The efficiency of a local antibiotic (ie, MTZ) or host modulator (ie, PTB) in halting the progression of periodontal destruction was evaluated using this nanosphere design.…”

Section: Introductionmentioning

confidence: 99%

“…Given that inflammation is characterized by a lower pH level, materials with pH‐dependent degradation or solubility features, such as chitosan or calcium phosphate, may be able to carry the drug to infected periodontal sites. Thus, our research team developed a chitosan‐based pH‐responsive hydrogel encapsulating PTB and showed favorable results for facilitating the recovery of experimental periodontitis . However, during periodontitis progression, inflammation could be more severe and lead to greater fluctuations of pH levels that might compromise the sustainability of molecules in the chitosan‐based carrier.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of periodontitis progression using pH‐responsive nanosphere encapsulating metronidazole or N‐phenacylthialzolium bromide

Lin

Fěng

et al. 2017

J of Periodontal Research

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Background and Objective This study aimed to develop pH‐responsive polylactide‐glycolic acid co‐polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation‐responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N‐phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis. Material and Methods PLGA/chitosan nanospheres were fabricated using oil‐in‐water emulsion method. Experimental periodontitis was induced on the rat maxillae, and the sites were randomly allocated to four treatment categories, including periodontitis alone (PR), periodontitis with nanospheres alone, nanospheres encapsulating metronidazole (MT) and nanospheres encapsulating PTB (PB). The ligature was retained until the animals were killed, and the treatment outcome was evaluated by the progression of periodontal bone loss (PPBL), inflammatory cell infiltration and collagen deposition. Results The encapsulated drug was released rapidly from the nanospheres without significant initial burst release at pH 5.5. Compared with group PR, PPBL was significantly reduced in groups MT and PB on day 4 (P<.05). On day 21, PPBL was significantly lower in group PB (P<.05). In groups MT and PB, inflammation was significantly reduced in groups MT and PB relative to groups PR and periodontitis with nanospheres alone (P<.05), and collagen deposition was significantly greater relative to group PR (P<.05). Conclusion PLGA/chitosan nanospheres encapsulating metronidazole or PTB showed potential for modulating periodontitis progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modulation of periodontitis progression using pH‐responsive nanosphere encapsulating metronidazole or N‐phenacylthialzolium bromide

Lin

Fěng

et al. 2017

J of Periodontal Research

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Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Yin

Yang

et al. 2023

Adv Funct Materials

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Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy.

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Biomedical applications of stimuli‐responsive nanomaterials

Chen,

Wu,

Chen

2024

MedComm

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Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond to endogenous or exogenous stimulus display strong potentials in biomedical applications. In comparison with conventional nanomaterials, stimuli‐responsive nanomaterials can improve therapeutic efficiency and reduce the toxicity of drugs toward normal tissues through specific targeting and on‐demand drug release at pathological sites. In this review, we summarize the responsive mechanism of a variety of stimulus, including pH, redox, and enzymes within pathological microenvironment, as well as exogenous stimulus such as thermal effect, magnetic field, light, and ultrasound. After that, biomedical applications (e.g., drug delivery, imaging, and theranostics) of stimuli‐responsive nanomaterials in a diverse array of common diseases, including cardiovascular diseases, cancer, neurological disorders, inflammation, and bacterial infection, are presented and discussed. Finally, the remaining challenges and outlooks of future research directions for the biomedical applications of stimuli‐responsive nanomaterials are also discussed. We hope that this review can provide valuable guidance for developing stimuli‐responsive nanomaterials and accelerate their biomedical applications in diseases diagnosis and treatment.

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pH‐Responsive Hydrogel With an Anti‐Glycation Agent for Modulating Experimental Periodontitis

Abstract: Chitosan-based, pH-responsive hydrogels loaded with PTB can retard the initiation of and facilitate the recovery from experimental periodontitis.

Cited by 18 publications

References 32 publications

Modulation of periodontitis progression using pH‐responsive nanosphere encapsulating metronidazole or N‐phenacylthialzolium bromide

Modulation of periodontitis progression using pH‐responsive nanosphere encapsulating metronidazole or N‐phenacylthialzolium bromide

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Biomedical applications of stimuli‐responsive nanomaterials

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