pH-responsive injectable polysaccharide hydrogels with self-healing, enhanced mechanical properties based on POSS

Zhang, Xiaojing; Yang, Meng; Shen, Weiwei; Dou, Jingcheng; Liu, Ruixue; Jin, Qiong‐Hua; Fang, Shaoming

doi:10.1016/j.reactfunctpolym.2020.104773

Cited by 22 publications

(5 citation statements)

References 42 publications

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“…This result could be associated with the high LOI values obtained for these hydrogel samples, which indicate more rigid hydrogels, but the energy/force put on it cannot be transferred away in time. The cationic octa ( γ -chloroammoniumpropyl) silsesquioxane-chitosan-oxidized hydroxypropyl cellulose hydrogels [ 54 ] have been previously reported to present a comparable behavior with our CCP-based hydrogels.…”

Section: Resultsmentioning

confidence: 52%

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Anghel¹,

Dinu²,

Vereştiuc

et al. 2021

Polymers

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Designing composites based on natural polymers has attracted attention for more than a decade due to the possibility to manufacture medical devices which are biocompatible with the human body. Herein, we present some biomaterials made up of collagen, polyurethane, and cellulose doped with lignin and lignin-metal complex, which served as transcutaneous drug delivery systems. Compared with base material, the compressive strength and the elastic modulus of biocomposites comprising lignin or lignin-metal complex were significantly enhanced; thus, the compressive strength increased from 61.37 to 186.5 kPa, while the elastic modulus increased from 0.828 to 1.928 MPa. The release of ketokonazole from the polymer matrix follows a Korsmeyer–Peppas type kinetics with a Fickian diffusion. All materials tested were shown to be active against pathogenic microorganisms. The mucoadhesiveness, bioadhesiveness, mechanical resistance, release kinetic, and antimicrobial activity make these biocomposites to be candidates as potential systems for controlled drug release.

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Section: Resultsmentioning

confidence: 52%

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Anghel¹,

Dinu²,

Vereştiuc

et al. 2021

Polymers

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“…pH-responsive nanocomposite hydrogels comprising chitosan, oxidized hydroxypropyl cellulose (HPC), and a water-soluble POSS, octa (γ-chloroammoniumpropyl) silsesquioxane (OCAPS), were also reported by Zhang et al [ 48 ]. The acid-labile Schiff base linkages were formed by the reaction of the aldehyde groups of HPC with the amine groups of chitosan, while OCAPS was bound via imine bonds onto HPC.…”

Section: Stimuli-responsive Polysaccharide-based Hydrogelsmentioning

confidence: 97%

Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

et al. 2023

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There is a growing concern about wound care, since traditional dressings such as bandages and sutures can no longer meet existing needs. To address the demanding requirements, naturally occurring polymers have been extensively exploited for use in modern wound management. Polysaccharides, being the most abundant biopolymers, have some distinct characteristics, including biocompatibility and biodegradability, which render them ideal candidates for wound healing applications. Combining them with inorganic and organic moieties can produce effective multifunctional composites with the desired mechanical properties, high wound healing efficiencies and excellent antibacterial behavior. Recent research endeavors focus on the development of stimuli-responsive polysaccharide composites for biomedical applications. Polysaccharide composites, being sensitive to the local environment, such as changes of the solution temperature, pH, etc., can sense and react to the wound conditions, thus promoting an effective interaction with the wound. This review highlights the recent advances in stimuli-responsive polysaccharide hydrogels and their composites for use in wound healing applications. The synthetic approaches, physical, chemical, and biochemical properties as well as their function in wound healing will be discussed.

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“…Their analysis could demonstrate a promising stability, cytocompatibility (more than 93%), as well as biodegradability (after 15 days at 37 1C). 230…”

Section: Polysaccharide Nanocomposites For Cell Encapsulationmentioning

confidence: 99%

Polysaccharide-based nanocomposites for biomedical applications: a critical review

Shokrani

Sajadi

et al. 2022

Nanoscale Horiz.

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pH-responsive injectable polysaccharide hydrogels with self-healing, enhanced mechanical properties based on POSS

Cited by 22 publications

References 42 publications

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

Polysaccharide-based nanocomposites for biomedical applications: a critical review

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